LOC103476647 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LOC103476647

Uncharacterized protein. (287 aa)

Predicted Functional Partners:

gldc

0.613

ENSPREP00000014189

0.551

LOC103479795

0.475

ENSPREP00000005699

0.474

nadk

0.468

bckdhb

0.465

ENSPREP00000006862

0.461

gcsh

0.461

oxa1l

0.446

dlat

0.446

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005699	LOC103476647	ENSPREP00000005699	ENSPREP00000010064	Transmembrane protein 126A.	Uncharacterized protein.	0.474
ENSPREP00000006862	ENSPREP00000014189	ENSPREP00000006862	ENSPREP00000014189	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.768
ENSPREP00000006862	LOC103476647	ENSPREP00000006862	ENSPREP00000010064	Uncharacterized protein.	Uncharacterized protein.	0.461
ENSPREP00000006862	bckdhb	ENSPREP00000006862	ENSPREP00000022601	Uncharacterized protein.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.776
ENSPREP00000006862	dlat	ENSPREP00000006862	ENSPREP00000026249	Uncharacterized protein.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.781
ENSPREP00000006862	gldc	ENSPREP00000006862	ENSPREP00000012159	Uncharacterized protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.993
ENSPREP00000014189	ENSPREP00000006862	ENSPREP00000014189	ENSPREP00000006862	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.768
ENSPREP00000014189	LOC103476647	ENSPREP00000014189	ENSPREP00000010064	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.551
ENSPREP00000014189	bckdhb	ENSPREP00000014189	ENSPREP00000022601	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.691
ENSPREP00000014189	dlat	ENSPREP00000014189	ENSPREP00000026249	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ENSPREP00000014189	gcsh	ENSPREP00000014189	ENSPREP00000034245	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.768
LOC103476647	ENSPREP00000005699	ENSPREP00000010064	ENSPREP00000005699	Uncharacterized protein.	Transmembrane protein 126A.	0.474
LOC103476647	ENSPREP00000006862	ENSPREP00000010064	ENSPREP00000006862	Uncharacterized protein.	Uncharacterized protein.	0.461
LOC103476647	ENSPREP00000014189	ENSPREP00000010064	ENSPREP00000014189	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.551
LOC103476647	LOC103479795	ENSPREP00000010064	ENSPREP00000020208	Uncharacterized protein.	NAD kinase b.	0.475
LOC103476647	bckdhb	ENSPREP00000010064	ENSPREP00000022601	Uncharacterized protein.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.465
LOC103476647	dlat	ENSPREP00000010064	ENSPREP00000026249	Uncharacterized protein.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.446
LOC103476647	gcsh	ENSPREP00000010064	ENSPREP00000034245	Uncharacterized protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.461
LOC103476647	gldc	ENSPREP00000010064	ENSPREP00000012159	Uncharacterized protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.613
LOC103476647	nadk	ENSPREP00000010064	ENSPREP00000015673	Uncharacterized protein.	NAD kinase a.	0.468

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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