nr2c2ap protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

nr2c2ap

Nuclear receptor 2C2-associated protein. (141 aa)

Predicted Functional Partners:

pdpk1

0.674

slc35e1

0.538

SUGP1

0.531

cherp

0.524

rfxank

0.499

ddx49

0.437

LOC103471437

0.414

LOC103475843

0.412

cask

0.412

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103471437	nr2c2ap	ENSPREP00000022799	ENSPREP00000010149	Zinc finger and BTB domain containing 3.	Nuclear receptor 2C2-associated protein.	0.414
LOC103475843	cask	ENSPREP00000013706	ENSPREP00000030734	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the MAGUK family.	0.761
LOC103475843	nr2c2ap	ENSPREP00000013706	ENSPREP00000010149	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	Nuclear receptor 2C2-associated protein.	0.412
SUGP1	ddx49	ENSPREP00000026584	ENSPREP00000016576	SURP and G-patch domain containing 1.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family.	0.491
SUGP1	nr2c2ap	ENSPREP00000026584	ENSPREP00000010149	SURP and G-patch domain containing 1.	Nuclear receptor 2C2-associated protein.	0.531
SUGP1	rfxank	ENSPREP00000026584	ENSPREP00000010168	SURP and G-patch domain containing 1.	Regulatory factor X-associated ankyrin-containing protein.	0.401
SUGP1	slc35e1	ENSPREP00000026584	ENSPREP00000016128	SURP and G-patch domain containing 1.	Solute carrier family 35 member E1.	0.525
cask	LOC103475843	ENSPREP00000030734	ENSPREP00000013706	Uncharacterized protein; Belongs to the MAGUK family.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.761
cask	nr2c2ap	ENSPREP00000030734	ENSPREP00000010149	Uncharacterized protein; Belongs to the MAGUK family.	Nuclear receptor 2C2-associated protein.	0.412
cherp	ddx49	ENSPREP00000030676	ENSPREP00000016576	Calcium homeostasis endoplasmic reticulum protein.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family.	0.546
cherp	nr2c2ap	ENSPREP00000030676	ENSPREP00000010149	Calcium homeostasis endoplasmic reticulum protein.	Nuclear receptor 2C2-associated protein.	0.524
cherp	rfxank	ENSPREP00000030676	ENSPREP00000010168	Calcium homeostasis endoplasmic reticulum protein.	Regulatory factor X-associated ankyrin-containing protein.	0.410
cherp	slc35e1	ENSPREP00000030676	ENSPREP00000016128	Calcium homeostasis endoplasmic reticulum protein.	Solute carrier family 35 member E1.	0.532
ddx49	SUGP1	ENSPREP00000016576	ENSPREP00000026584	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family.	SURP and G-patch domain containing 1.	0.491
ddx49	cherp	ENSPREP00000016576	ENSPREP00000030676	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family.	Calcium homeostasis endoplasmic reticulum protein.	0.546
ddx49	nr2c2ap	ENSPREP00000016576	ENSPREP00000010149	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family.	Nuclear receptor 2C2-associated protein.	0.437
ddx49	slc35e1	ENSPREP00000016576	ENSPREP00000016128	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49; Belongs to the DEAD box helicase family.	Solute carrier family 35 member E1.	0.418
nr2c2ap	LOC103471437	ENSPREP00000010149	ENSPREP00000022799	Nuclear receptor 2C2-associated protein.	Zinc finger and BTB domain containing 3.	0.414
nr2c2ap	LOC103475843	ENSPREP00000010149	ENSPREP00000013706	Nuclear receptor 2C2-associated protein.	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family.	0.412
nr2c2ap	SUGP1	ENSPREP00000010149	ENSPREP00000026584	Nuclear receptor 2C2-associated protein.	SURP and G-patch domain containing 1.	0.531

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.87

expected number of edges:

13

PPI enrichment p-value:

8.46e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016567

Protein ubiquitination

7 of 555

1.28

1.3

0.00013

GO:0006511

Ubiquitin-dependent protein catabolic process

6 of 429

1.32

1.27

0.00029

GO:0006508

Proteolysis

7 of 982

1.03

0.9

0.00069

GO:0019538

Protein metabolic process

9 of 3206

0.63

0.45

0.0081

GO:0043170

Macromolecule metabolic process

11 of 4794

0.54

0.44

0.00096

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

4 of 174

1.54

0.93

0.0105

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

2 of 13

2.37

0.88

0.0241

GO:0030674

Protein-macromolecule adaptor activity

4 of 249

1.38

0.83

0.0141

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070449

Elongin complex

3 of 4

3.05

3.01

3.33e-06

GO:0000151

Ubiquitin ligase complex

6 of 246

1.57

2.06

3.28e-06

GO:0030891

VCB complex

2 of 2

3.18

1.88

0.00041

GO:1990234

Transferase complex

8 of 663

1.26

1.59

1.33e-06

GO:0031466

Cul5-RING ubiquitin ligase complex

2 of 6

2.7

1.55

0.0015

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33849568

(2021) The role of SOCS proteins in the development of virus- induced hepatocellular carcinoma.

4 of 27

2.35

2.42

2.37e-05

PMID:34803084

(2022) Viral deubiquitinases and innate antiviral immune response in livestock and poultry.

3 of 21

2.33

1.5

0.0016

PMID:29235573

(2017) Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells.

3 of 40

2.05

1.15

0.0064

PMID:37762376

(2023) VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma.

2 of 4

2.88

1.09

0.0109

PMID:37127643

(2023) The interactions between PML nuclear bodies and small and medium size DNA viruses.

2 of 8

2.58

0.87

0.0262

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1562

Protein neddylation, and 1-phosphatidylinositol-3-kinase regulator activity

9 of 19

2.85

10.36

5.25e-21

CL:1565

Mixed, incl. VCB complex, and Cullin, conserved site

8 of 10

3.08

10.19

6.14e-20

CL:1569

VCB complex, and SKP1 component, POZ domain

5 of 5

3.18

6.09

6.77e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla04120

Ubiquitin mediated proteolysis

4 of 98

1.79

1.9

7.07e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

5 of 26

2.46

4.19

6.15e-09

MAP-1234174

Cellular response to hypoxia

5 of 32

2.37

4.01

1.05e-08

MAP-8951664

Neddylation

9 of 264

1.71

3.64

6.79e-12

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

7 of 364

1.46

2.09

3.32e-07

MAP-983169

Class I MHC mediated antigen processing & presentation

7 of 419

1.4

1.91

6.97e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000151

Ubiquitin ligase complex

6 of 191

1.68

2.3

1.74e-06

GOCC:0070449

Elongin complex

2 of 3

3.0

1.68

0.00092

GOCC:0030891

VCB complex

2 of 2

3.18

1.68

0.00092

GOCC:0031466

Cul5-RING ubiquitin ligase complex

2 of 6

2.7

1.47

0.0021

GOCC:0031461

cullin-RING ubiquitin ligase complex

4 of 129

1.67

1.46

0.00064

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024766

Zinc finger, RING-H2-type

2 of 3

3.0

0.9

0.0241

IPR016157

Cullin, conserved site

2 of 3

3.0

0.9

0.0241

IPR045093

Cullin

2 of 6

2.7

0.89

0.0241

IPR036317

Cullin homology domain superfamily

2 of 7

2.64

0.89

0.0241

IPR019559

Cullin protein, neddylation domain

2 of 6

2.7

0.89

0.0241

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 6

2.7

1.15

0.0081

SM00182

Cullin

2 of 7

2.64

1.15

0.0081

SM00969

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

2 of 27

2.05

0.76

0.0389

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