ENSPREP00000010642 protein (Poecilia reticulata)

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ENSPREP00000010642

Uncharacterized protein. (57 aa)

Predicted Functional Partners:

CEP97

0.894

ENSPREP00000014759

0.819

plk4

0.668

cep76

0.618

usp33

0.609

usp20

0.609

cep290

0.607

ENSPREP00000004463

0.607

ENSPREP00000010317

0.607

PLK1

0.522

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP97	ENSPREP00000004463	ENSPREP00000014711	ENSPREP00000004463	Centrosomal protein 97.	Uncharacterized protein.	0.531
CEP97	ENSPREP00000010317	ENSPREP00000014711	ENSPREP00000010317	Centrosomal protein 97.	Uncharacterized protein.	0.531
CEP97	ENSPREP00000010642	ENSPREP00000014711	ENSPREP00000010642	Centrosomal protein 97.	Uncharacterized protein.	0.894
CEP97	ENSPREP00000014759	ENSPREP00000014711	ENSPREP00000014759	Centrosomal protein 97.	Uncharacterized protein.	0.899
CEP97	cep290	ENSPREP00000014711	ENSPREP00000004440	Centrosomal protein 97.	Centrosomal protein 290.	0.531
CEP97	cep76	ENSPREP00000014711	ENSPREP00000016992	Centrosomal protein 97.	Centrosomal protein 76.	0.479
ENSPREP00000004463	CEP97	ENSPREP00000004463	ENSPREP00000014711	Uncharacterized protein.	Centrosomal protein 97.	0.531
ENSPREP00000004463	ENSPREP00000010642	ENSPREP00000004463	ENSPREP00000010642	Uncharacterized protein.	Uncharacterized protein.	0.607
ENSPREP00000004463	ENSPREP00000014759	ENSPREP00000004463	ENSPREP00000014759	Uncharacterized protein.	Uncharacterized protein.	0.456
ENSPREP00000004463	PLK1	ENSPREP00000004463	ENSPREP00000000056	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.579
ENSPREP00000004463	cep76	ENSPREP00000004463	ENSPREP00000016992	Uncharacterized protein.	Centrosomal protein 76.	0.532
ENSPREP00000004463	plk4	ENSPREP00000004463	ENSPREP00000021717	Uncharacterized protein.	Polo-like kinase 4 (Drosophila).	0.514
ENSPREP00000010317	CEP97	ENSPREP00000010317	ENSPREP00000014711	Uncharacterized protein.	Centrosomal protein 97.	0.531
ENSPREP00000010317	ENSPREP00000010642	ENSPREP00000010317	ENSPREP00000010642	Uncharacterized protein.	Uncharacterized protein.	0.607
ENSPREP00000010317	ENSPREP00000014759	ENSPREP00000010317	ENSPREP00000014759	Uncharacterized protein.	Uncharacterized protein.	0.456
ENSPREP00000010317	PLK1	ENSPREP00000010317	ENSPREP00000000056	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.579
ENSPREP00000010317	cep76	ENSPREP00000010317	ENSPREP00000016992	Uncharacterized protein.	Centrosomal protein 76.	0.532
ENSPREP00000010317	plk4	ENSPREP00000010317	ENSPREP00000021717	Uncharacterized protein.	Polo-like kinase 4 (Drosophila).	0.514
ENSPREP00000010642	CEP97	ENSPREP00000010642	ENSPREP00000014711	Uncharacterized protein.	Centrosomal protein 97.	0.894
ENSPREP00000010642	ENSPREP00000004463	ENSPREP00000010642	ENSPREP00000004463	Uncharacterized protein.	Uncharacterized protein.	0.607

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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