STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kcnj8Potassium inwardly-rectifying channel, subfamily J, member 8. (418 aa)    
Predicted Functional Partners:
LOC103460789
ATP-binding cassette, sub-family C (CFTR/MRP), member 9.
 
 
 0.964
abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8.
 
 
 0.935
LOC103458407
Rap guanine nucleotide exchange factor (GEF) 4.
   
 
 0.656
Pln
Uncharacterized protein.
   
  
 0.650
LOC103467797
Rap guanine nucleotide exchange factor (GEF) 3.
     
 0.645
LOC103470120
SET and MYND domain containing 1b.
   
  
 0.481
abcc5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5.
   
 0.446
abcc12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12.
   
 0.446
LOC103471521
Si:ch211-221f10.2.
   
 0.446
cftr
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
   
 0.445
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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