LOC103474095 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LOC103474095

Family with sequence similarity 102 member Ab. (325 aa)

Predicted Functional Partners:

sec61g

0.617

rpl9

0.443

pin1

0.439

mrps5

0.423

rpl23

0.421

LOC103477466

0.420

Pi4kb

0.420

rps3

0.419

rps15

0.418

rpl32

0.418

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103474095	LOC103477466	ENSPREP00000011060	ENSPREP00000022829	Family with sequence similarity 102 member Ab.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.420
LOC103474095	Pi4kb	ENSPREP00000011060	ENSPREP00000024565	Family with sequence similarity 102 member Ab.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.420
LOC103474095	mrps5	ENSPREP00000011060	ENSPREP00000002339	Family with sequence similarity 102 member Ab.	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	0.423
LOC103474095	pin1	ENSPREP00000011060	ENSPREP00000000046	Family with sequence similarity 102 member Ab.	Peptidyl-prolyl cis-trans isomerase.	0.439
LOC103474095	rpl23	ENSPREP00000011060	ENSPREP00000011518	Family with sequence similarity 102 member Ab.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.421
LOC103474095	rpl32	ENSPREP00000011060	ENSPREP00000025423	Family with sequence similarity 102 member Ab.	Ribosomal protein L32.	0.418
LOC103474095	rpl9	ENSPREP00000011060	ENSPREP00000010907	Family with sequence similarity 102 member Ab.	Ribosomal protein L9.	0.443
LOC103474095	rps15	ENSPREP00000011060	ENSPREP00000013069	Family with sequence similarity 102 member Ab.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.418
LOC103474095	rps3	ENSPREP00000011060	ENSPREP00000025968	Family with sequence similarity 102 member Ab.	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.419
LOC103474095	sec61g	ENSPREP00000011060	ENSPREP00000022790	Family with sequence similarity 102 member Ab.	SEC61 translocon gamma subunit.	0.617
LOC103477466	LOC103474095	ENSPREP00000022829	ENSPREP00000011060	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Family with sequence similarity 102 member Ab.	0.420
Pi4kb	LOC103474095	ENSPREP00000024565	ENSPREP00000011060	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	Family with sequence similarity 102 member Ab.	0.420
mrps5	LOC103474095	ENSPREP00000002339	ENSPREP00000011060	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	Family with sequence similarity 102 member Ab.	0.423
mrps5	rpl23	ENSPREP00000002339	ENSPREP00000011518	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.999
mrps5	rpl32	ENSPREP00000002339	ENSPREP00000025423	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	Ribosomal protein L32.	0.999
mrps5	rpl9	ENSPREP00000002339	ENSPREP00000010907	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	Ribosomal protein L9.	0.999
mrps5	rps15	ENSPREP00000002339	ENSPREP00000013069	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
mrps5	rps3	ENSPREP00000002339	ENSPREP00000025968	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.999
mrps5	sec61g	ENSPREP00000002339	ENSPREP00000022790	Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.	SEC61 translocon gamma subunit.	0.742
pin1	LOC103474095	ENSPREP00000000046	ENSPREP00000011060	Peptidyl-prolyl cis-trans isomerase.	Family with sequence similarity 102 member Ab.	0.439

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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