ENSPREP00000011196 protein (Poecilia reticulata)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSPREP00000011196

Histone H2A; Belongs to the histone H2A family. (130 aa)

Predicted Functional Partners:

mysm1

0.978

ENSPREP00000011248

0.809

ENSPREP00000012739

0.792

ENSPREP00000007848

0.789

ENSPREP00000009448

0.789

LOC103479695

0.789

LOC103467542

0.789

ENSPREP00000012897

0.783

LOC103472958

0.782

ENSPREP00000008908

0.781

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000007848	ENSPREP00000011196	ENSPREP00000007848	ENSPREP00000011196	Histone H2B; Belongs to the histone H2B family.	Histone H2A; Belongs to the histone H2A family.	0.789
ENSPREP00000007848	mysm1	ENSPREP00000007848	ENSPREP00000031373	Histone H2B; Belongs to the histone H2B family.	Myb-like, SWIRM and MPN domains 1.	0.457
ENSPREP00000008908	ENSPREP00000011196	ENSPREP00000008908	ENSPREP00000011196	Histone H2B; Belongs to the histone H2B family.	Histone H2A; Belongs to the histone H2A family.	0.781
ENSPREP00000008908	mysm1	ENSPREP00000008908	ENSPREP00000031373	Histone H2B; Belongs to the histone H2B family.	Myb-like, SWIRM and MPN domains 1.	0.457
ENSPREP00000009448	ENSPREP00000011196	ENSPREP00000009448	ENSPREP00000011196	Histone H2B; Belongs to the histone H2B family.	Histone H2A; Belongs to the histone H2A family.	0.789
ENSPREP00000009448	mysm1	ENSPREP00000009448	ENSPREP00000031373	Histone H2B; Belongs to the histone H2B family.	Myb-like, SWIRM and MPN domains 1.	0.457
ENSPREP00000011196	ENSPREP00000007848	ENSPREP00000011196	ENSPREP00000007848	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.789
ENSPREP00000011196	ENSPREP00000008908	ENSPREP00000011196	ENSPREP00000008908	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.781
ENSPREP00000011196	ENSPREP00000009448	ENSPREP00000011196	ENSPREP00000009448	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.789
ENSPREP00000011196	ENSPREP00000011248	ENSPREP00000011196	ENSPREP00000011248	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.809
ENSPREP00000011196	ENSPREP00000012739	ENSPREP00000011196	ENSPREP00000012739	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.792
ENSPREP00000011196	ENSPREP00000012897	ENSPREP00000011196	ENSPREP00000012897	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.783
ENSPREP00000011196	LOC103467542	ENSPREP00000011196	ENSPREP00000027931	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.789
ENSPREP00000011196	LOC103472958	ENSPREP00000011196	ENSPREP00000000288	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.782
ENSPREP00000011196	LOC103479695	ENSPREP00000011196	ENSPREP00000011921	Histone H2A; Belongs to the histone H2A family.	Histone H2B; Belongs to the histone H2B family.	0.789
ENSPREP00000011196	mysm1	ENSPREP00000011196	ENSPREP00000031373	Histone H2A; Belongs to the histone H2A family.	Myb-like, SWIRM and MPN domains 1.	0.978
ENSPREP00000011248	ENSPREP00000011196	ENSPREP00000011248	ENSPREP00000011196	Histone H2B; Belongs to the histone H2B family.	Histone H2A; Belongs to the histone H2A family.	0.809
ENSPREP00000011248	mysm1	ENSPREP00000011248	ENSPREP00000031373	Histone H2B; Belongs to the histone H2B family.	Myb-like, SWIRM and MPN domains 1.	0.457
ENSPREP00000012739	ENSPREP00000011196	ENSPREP00000012739	ENSPREP00000011196	Histone H2B; Belongs to the histone H2B family.	Histone H2A; Belongs to the histone H2A family.	0.792
ENSPREP00000012739	mysm1	ENSPREP00000012739	ENSPREP00000031373	Histone H2B; Belongs to the histone H2B family.	Myb-like, SWIRM and MPN domains 1.	0.457

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.879

expected number of edges:

11

PPI enrichment p-value:

1.43e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000281

Mitotic cytokinesis

6 of 32

1.79

2.63

5.40e-07

GO:0000910

Cytokinesis

7 of 53

1.64

2.48

2.15e-07

GO:1902404

Mitotic actomyosin contractile ring contraction

4 of 10

2.12

2.39

1.66e-05

GO:0032506

Cytokinetic process

5 of 41

1.61

1.85

2.79e-05

GO:0030036

Actin cytoskeleton organization

6 of 63

1.5

1.84

9.47e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051015

Actin filament binding

5 of 27

1.79

2.12

1.71e-05

GO:0005516

Calmodulin binding

3 of 7

2.15

1.67

0.00062

GO:0008092

Cytoskeletal protein binding

6 of 104

1.28

1.29

0.00014

GO:0000146

Microfilament motor activity

2 of 4

2.22

0.91

0.0210

GO:0005515

Protein binding

7 of 540

0.63

0.37

0.0457

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016459

Myosin complex

5 of 7

2.37

3.81

2.85e-08

GO:0015629

Actin cytoskeleton

8 of 71

1.57

2.69

4.47e-09

GO:0110085

Mitotic actomyosin contractile ring

5 of 22

1.88

2.66

9.48e-07

GO:0030864

Cortical actin cytoskeleton

7 of 57

1.61

2.6

3.22e-08

GO:0016460

Myosin II complex

3 of 3

2.52

2.41

3.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:419

Actomyosin structure organization, and Calponin homology domain

6 of 17

2.07

3.64

1.01e-08

CL:421

Actomyosin structure organization

5 of 12

2.14

3.29

1.36e-07

CL:422

Myosin II complex, and RasGAP C-terminus

4 of 6

2.34

2.97

1.68e-06

CL:130

Mixed, incl. Calcium-mediated signaling, and Myosin complex

4 of 12

2.04

2.46

8.25e-06

CL:93

Mixed, incl. Microtubule cytoskeleton organization, and Regulation of calcium ion transmembrane transport

5 of 42

1.59

1.96

1.12e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04070

Phosphatidylinositol signaling system

3 of 28

1.55

0.93

0.0110

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5627123

RHO GTPases activate PAKs

3 of 6

2.22

1.76

0.00044

MAP-195258

RHO GTPase Effectors

5 of 74

1.35

1.25

0.00044

MAP-9716542

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

7 of 162

1.15

1.21

4.45e-05

MAP-194315

Signaling by Rho GTPases

6 of 157

1.1

1.0

0.00044

MAP-162582

Signal Transduction

9 of 351

0.93

0.92

2.90e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016459

Myosin complex

5 of 9

2.26

3.54

7.20e-08

GOCC:0015629

Actin cytoskeleton

8 of 63

1.62

2.9

1.84e-09

GOCC:0005856

Cytoskeleton

9 of 197

1.18

1.56

7.20e-08

GOCC:0016460

Myosin II complex

2 of 2

2.52

1.27

0.0046

GOCC:0110085

Mitotic actomyosin contractile ring

3 of 17

1.77

1.22

0.0032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 3

2.34

1.13

0.0081

KW-0106

Calcium

3 of 18

1.74

1.12

0.0052

KW-0009

Actin-binding

2 of 13

1.71

0.71

0.0417

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000048

IQ motif, EF-hand binding site

3 of 5

2.3

1.49

0.0016

IPR018247

EF-Hand 1, calcium-binding site

3 of 13

1.88

1.07

0.0081

IPR011992

EF-hand domain pair

3 of 17

1.77

0.99

0.0109

IPR002048

EF-hand domain

3 of 17

1.77

0.99

0.0109

IPR001609

Myosin head, motor domain

2 of 3

2.34

0.89

0.0237

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00015

Short calmodulin-binding motif containing conserved Ile and Gln residues.

3 of 4

2.39

2.02

0.00016

SM00054

EF-hand, calcium binding motif

3 of 11

1.95

1.55

0.00083

SM00242

Myosin. Large ATPases.

2 of 3

2.34

1.19

0.0062

SM00033

Calponin homology domain

2 of 4

2.22

1.15

0.0070

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