ENSPREP00000011559 protein (Poecilia reticulata)

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white nodes:
second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSPREP00000011559

Uncharacterized protein. (69 aa)

Predicted Functional Partners:

adhfe1

0.982

SRF

0.809

srf

0.809

hsdl2

0.793

hacl1

0.782

ilvbl

0.782

sord

0.781

LOC103468150

0.673

aoc1

0.673

ENSPREP00000002631

0.564

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002631	ENSPREP00000011559	ENSPREP00000002631	ENSPREP00000011559	ACAS_N domain-containing protein.	Uncharacterized protein.	0.564
ENSPREP00000002631	adhfe1	ENSPREP00000002631	ENSPREP00000001695	ACAS_N domain-containing protein.	Alcohol dehydrogenase iron containing 1.	0.722
ENSPREP00000002631	hsdl2	ENSPREP00000002631	ENSPREP00000025733	ACAS_N domain-containing protein.	Hydroxysteroid dehydrogenase like 2.	0.838
ENSPREP00000002631	sord	ENSPREP00000002631	ENSPREP00000033815	ACAS_N domain-containing protein.	Sorbitol dehydrogenase.	0.624
ENSPREP00000011559	ENSPREP00000002631	ENSPREP00000011559	ENSPREP00000002631	Uncharacterized protein.	ACAS_N domain-containing protein.	0.564
ENSPREP00000011559	LOC103468150	ENSPREP00000011559	ENSPREP00000009615	Uncharacterized protein.	Amine oxidase.	0.673
ENSPREP00000011559	SRF	ENSPREP00000011559	ENSPREP00000008765	Uncharacterized protein.	Serum response factor.	0.809
ENSPREP00000011559	adhfe1	ENSPREP00000011559	ENSPREP00000001695	Uncharacterized protein.	Alcohol dehydrogenase iron containing 1.	0.982
ENSPREP00000011559	aoc1	ENSPREP00000011559	ENSPREP00000017824	Uncharacterized protein.	Amine oxidase.	0.673
ENSPREP00000011559	hacl1	ENSPREP00000011559	ENSPREP00000002472	Uncharacterized protein.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.782
ENSPREP00000011559	hsdl2	ENSPREP00000011559	ENSPREP00000025733	Uncharacterized protein.	Hydroxysteroid dehydrogenase like 2.	0.793
ENSPREP00000011559	ilvbl	ENSPREP00000011559	ENSPREP00000007371	Uncharacterized protein.	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family.	0.782
ENSPREP00000011559	sord	ENSPREP00000011559	ENSPREP00000033815	Uncharacterized protein.	Sorbitol dehydrogenase.	0.781
ENSPREP00000011559	srf	ENSPREP00000011559	ENSPREP00000012906	Uncharacterized protein.	Serum response factor b.	0.809
LOC103468150	ENSPREP00000011559	ENSPREP00000009615	ENSPREP00000011559	Amine oxidase.	Uncharacterized protein.	0.673
LOC103468150	adhfe1	ENSPREP00000009615	ENSPREP00000001695	Amine oxidase.	Alcohol dehydrogenase iron containing 1.	0.852
LOC103468150	hsdl2	ENSPREP00000009615	ENSPREP00000025733	Amine oxidase.	Hydroxysteroid dehydrogenase like 2.	0.522
LOC103468150	sord	ENSPREP00000009615	ENSPREP00000033815	Amine oxidase.	Sorbitol dehydrogenase.	0.538
SRF	ENSPREP00000011559	ENSPREP00000008765	ENSPREP00000011559	Serum response factor.	Uncharacterized protein.	0.809
adhfe1	ENSPREP00000002631	ENSPREP00000001695	ENSPREP00000002631	Alcohol dehydrogenase iron containing 1.	ACAS_N domain-containing protein.	0.722

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.871

expected number of edges:

10

PPI enrichment p-value:

0.000306

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033198

Response to ATP

5 of 14

2.87

5.17

2.21e-10

GO:0032732

Positive regulation of interleukin-1 production

4 of 34

2.39

2.96

1.91e-06

GO:0035590

Purinergic nucleotide receptor signaling pathway

4 of 36

2.36

2.93

2.13e-06

GO:0006812

Cation transport

11 of 975

1.37

2.43

7.37e-12

GO:0002931

Response to ischemia

3 of 17

2.56

2.32

4.77e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035381

ATP-gated ion channel activity

3 of 9

2.84

2.91

4.43e-06

GO:0005261

Cation channel activity

8 of 469

1.55

2.69

2.02e-09

GO:0015267

Channel activity

9 of 648

1.46

2.54

3.54e-10

GO:0008324

Cation transmembrane transporter activity

10 of 823

1.4

2.42

1.11e-10

GO:0001614

Purinergic nucleotide receptor activity

3 of 23

2.43

2.31

4.41e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005639

Integral component of nuclear inner membrane

3 of 12

2.72

2.35

4.73e-05

GO:0005921

Gap junction

3 of 43

2.16

1.91

0.00020

GO:0005911

Cell-cell junction

4 of 389

1.33

0.99

0.0036

GO:0030054

Cell junction

6 of 1752

0.85

0.59

0.0082

GO:0120025

Plasma membrane bounded cell projection

6 of 1857

0.83

0.57

0.0091

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43862

Nucleotide receptor activity, and TMEM119 family

7 of 24

2.78

7.35

6.66e-15

CL:43865

ATP P2X receptor, and Innexin

5 of 10

3.02

5.6

4.43e-11

CL:43868

ATP P2X receptor

2 of 5

2.92

1.25

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04621

NOD-like receptor signaling pathway

3 of 133

1.67

1.09

0.0054

pret04020

Calcium signaling pathway

3 of 250

1.4

0.8

0.0172

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112307

Transmission across Electrical Synapses

3 of 10

2.79

2.4

3.93e-05

MAP-112303

Electric Transmission Across Gap Junctions

3 of 10

2.79

2.4

3.93e-05

MAP-139853

Elevation of cytosolic Ca2+ levels

3 of 21

2.47

2.16

9.24e-05

MAP-844456

The NLRP3 inflammasome

3 of 27

2.36

2.04

0.00014

MAP-9730628

Sensory perception of salty taste

2 of 2

3.32

1.96

0.00030

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005639

Integral component of nuclear inner membrane

3 of 11

2.75

2.36

4.60e-05

GOCC:0005921

Gap junction

3 of 38

2.21

1.8

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0407

Ion channel

6 of 308

1.61

2.26

9.31e-07

KW-0303

Gap junction

3 of 41

2.18

2.16

5.96e-05

KW-0325

Glycoprotein

3 of 61

2.01

1.91

0.00014

KW-1071

Ligand-gated ion channel

2 of 63

1.82

0.94

0.0144

KW-1133

Transmembrane helix

11 of 5706

0.6

0.54

2.64e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00876

Innexin

3 of 4

3.19

2.86

6.58e-06

PF00864

ATP P2X receptor

3 of 7

2.95

2.71

1.13e-05

PF14798

Calcium homeostasis modulator

2 of 5

2.92

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039099

Pannexin

3 of 4

3.19

2.59

2.05e-05

IPR000990

Innexin

3 of 4

3.19

2.59

2.05e-05

IPR027309

P2X purinoreceptor extracellular domain superfamily

3 of 7

2.95

2.54

2.35e-05

IPR001429

P2X purinoreceptor

3 of 7

2.95

2.54

2.35e-05

IPR029569

Calcium homeostasis modulator family

2 of 5

2.92

1.22

0.0063

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