STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hspb1Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)    
Predicted Functional Partners:
LOC103464872
MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.
   
 0.994
mapkapk5
MAPK activated protein kinase 5.
    
 0.984
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
   
 0.980
LOC103465075
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
   
 0.980
LOC103473747
Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.
     
 
0.900
bag3
BCL2 associated athanogene 3.
   
 
 0.698
hspb8
Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.
   
 
0.635
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.628
LOC103475461
Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.
   
0.601
LOC103469615
Ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2; Belongs to the GDA1/CD39 NTPase family.
      
 0.597
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.