hsd11b1l protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

hsd11b1l

Hydroxysteroid (11-beta) dehydrogenase 1-like a. (287 aa)

Predicted Functional Partners:

LOC103478110

0.925

LOC103478543

0.918

LOC103462617

0.916

LOC103459507

0.912

AKR1D1

0.912

LOC103477979

0.905

LOC103463669

0.901

LOC103462689

0.656

LOC103469917

0.656

LOC103469916

0.656

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1D1	LOC103459507	ENSPREP00000017249	ENSPREP00000013284	Aldo-keto reductase family 1 member D1.	Aldo_ket_red domain-containing protein.	0.901
AKR1D1	LOC103462689	ENSPREP00000017249	ENSPREP00000007316	Aldo-keto reductase family 1 member D1.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.670
AKR1D1	LOC103463669	ENSPREP00000017249	ENSPREP00000012040	Aldo-keto reductase family 1 member D1.	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	0.912
AKR1D1	LOC103469916	ENSPREP00000017249	ENSPREP00000010434	Aldo-keto reductase family 1 member D1.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.671
AKR1D1	LOC103469917	ENSPREP00000017249	ENSPREP00000010343	Aldo-keto reductase family 1 member D1.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.671
AKR1D1	LOC103477979	ENSPREP00000017249	ENSPREP00000000842	Aldo-keto reductase family 1 member D1.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.	0.908
AKR1D1	LOC103478110	ENSPREP00000017249	ENSPREP00000010135	Aldo-keto reductase family 1 member D1.	Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.902
AKR1D1	LOC103478543	ENSPREP00000017249	ENSPREP00000003751	Aldo-keto reductase family 1 member D1.	Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family.	0.902
AKR1D1	hsd11b1l	ENSPREP00000017249	ENSPREP00000012029	Aldo-keto reductase family 1 member D1.	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	0.912
LOC103459507	AKR1D1	ENSPREP00000013284	ENSPREP00000017249	Aldo_ket_red domain-containing protein.	Aldo-keto reductase family 1 member D1.	0.901
LOC103459507	LOC103462689	ENSPREP00000013284	ENSPREP00000007316	Aldo_ket_red domain-containing protein.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.670
LOC103459507	LOC103463669	ENSPREP00000013284	ENSPREP00000012040	Aldo_ket_red domain-containing protein.	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	0.912
LOC103459507	LOC103469916	ENSPREP00000013284	ENSPREP00000010434	Aldo_ket_red domain-containing protein.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.671
LOC103459507	LOC103469917	ENSPREP00000013284	ENSPREP00000010343	Aldo_ket_red domain-containing protein.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.671
LOC103459507	LOC103477979	ENSPREP00000013284	ENSPREP00000000842	Aldo_ket_red domain-containing protein.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.	0.908
LOC103459507	LOC103478110	ENSPREP00000013284	ENSPREP00000010135	Aldo_ket_red domain-containing protein.	Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	0.902
LOC103459507	LOC103478543	ENSPREP00000013284	ENSPREP00000003751	Aldo_ket_red domain-containing protein.	Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family.	0.902
LOC103459507	hsd11b1l	ENSPREP00000013284	ENSPREP00000012029	Aldo_ket_red domain-containing protein.	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	0.912
LOC103462617	LOC103462689	ENSPREP00000012206	ENSPREP00000007316	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.919
LOC103462617	LOC103463669	ENSPREP00000012206	ENSPREP00000012040	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	Hydroxysteroid (11-beta) dehydrogenase 1-like a.	0.916

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.905

expected number of edges:

17

PPI enrichment p-value:

0.0865

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032224

Positive regulation of synaptic transmission, cholinergic

3 of 5

3.1

2.82

7.57e-06

GO:0045995

Regulation of embryonic development

4 of 61

2.13

2.33

2.24e-05

GO:0000904

Cell morphogenesis involved in differentiation

7 of 515

1.45

1.89

2.56e-06

GO:0009887

Animal organ morphogenesis

8 of 749

1.35

1.74

1.71e-06

GO:0007411

Axon guidance

5 of 249

1.62

1.74

7.22e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005201

Extracellular matrix structural constituent

6 of 134

1.97

3.22

5.71e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005604

Basement membrane

8 of 77

2.33

6.55

5.35e-15

GO:0031012

Extracellular matrix

9 of 489

1.58

3.08

3.42e-11

GO:0043083

Synaptic cleft

3 of 9

2.84

2.95

3.81e-06

GO:0031594

Neuromuscular junction

3 of 44

2.15

1.86

0.00024

GO:0042383

Sarcolemma

3 of 77

1.91

1.49

0.0010

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36142434

(2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii).

3 of 13

2.68

2.39

3.80e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21899

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

8 of 14

3.07

10.0

1.42e-19

CL:21782

ECM-receptor interaction, and Laminin interactions

9 of 77

2.39

7.74

8.90e-18

CL:21901

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

4 of 7

3.07

4.56

4.34e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04512

ECM-receptor interaction

5 of 84

2.09

3.38

6.00e-08

pret04510

Focal adhesion

5 of 212

1.69

2.26

2.69e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000157

Laminin interactions

8 of 40

2.62

8.04

5.57e-17

MAP-8874081

MET activates PTK2 signaling

5 of 22

2.67

4.84

5.93e-10

MAP-8875878

MET promotes cell motility

5 of 38

2.44

4.23

4.69e-09

MAP-6806834

Signaling by MET

5 of 78

2.12

3.36

8.42e-08

MAP-3000171

Non-integrin membrane-ECM interactions

4 of 51

2.21

2.79

2.70e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

3 of 407

1.19

0.81

0.0076

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005604

Basement membrane

8 of 56

2.47

7.27

6.00e-16

GOCC:0062023

Collagen-containing extracellular matrix

9 of 190

1.99

5.33

9.90e-15

GOCC:0005610

laminin-5 complex

4 of 7

3.07

4.6

3.65e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0424

Laminin EGF-like domain

5 of 38

2.44

4.33

2.83e-09

KW-1015

Disulfide bond

5 of 1351

0.89

0.49

0.0415

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002049

Laminin-type EGF domain

6 of 51

2.39

4.58

5.94e-10

IPR000034

Laminin IV

4 of 6

3.14

4.2

2.16e-08

IPR008211

Laminin, N-terminal

4 of 23

2.56

3.14

1.20e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00180

Laminin-type epidermal growth factor-like domai

6 of 42

2.47

5.32

2.20e-11

SM00136

Laminin N-terminal domain (domain VI)

4 of 22

2.58

3.57

1.67e-07

SM00001

EGF domain, unclasssified subfamily

4 of 92

1.96

2.21

2.44e-05

SM00281

Laminin B domain

2 of 4

3.02

1.78

0.00061

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