LOC103462620 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

LOC103462620

Uncharacterized protein. (254 aa)

Predicted Functional Partners:

ptch2

0.969

ptch1

0.969

cdon

0.935

boc

0.935

Gas1

0.906

ENSPREP00000030267

0.905

lrp2

0.903

LOC103473569

0.903

ENSPREP00000033800

0.903

shh

0.831

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000030267	ENSPREP00000033800	ENSPREP00000030267	ENSPREP00000033800	Growth arrest-specific 1b.	Uncharacterized protein.	0.903
ENSPREP00000030267	Gas1	ENSPREP00000030267	ENSPREP00000013011	Growth arrest-specific 1b.	Growth arrest-specific 1a.	0.903
ENSPREP00000030267	LOC103462620	ENSPREP00000030267	ENSPREP00000012147	Growth arrest-specific 1b.	Uncharacterized protein.	0.905
ENSPREP00000030267	LOC103473569	ENSPREP00000030267	ENSPREP00000008924	Growth arrest-specific 1b.	Uncharacterized protein.	0.903
ENSPREP00000030267	boc	ENSPREP00000030267	ENSPREP00000028078	Growth arrest-specific 1b.	BOC cell adhesion associated, oncogene regulated.	0.926
ENSPREP00000030267	cdon	ENSPREP00000030267	ENSPREP00000024005	Growth arrest-specific 1b.	Cell adhesion associated, oncogene regulated.	0.926
ENSPREP00000030267	lrp2	ENSPREP00000030267	ENSPREP00000004371	Growth arrest-specific 1b.	Low density lipoprotein receptor-related protein 2a.	0.903
ENSPREP00000030267	ptch1	ENSPREP00000030267	ENSPREP00000024948	Growth arrest-specific 1b.	Patched 1.	0.962
ENSPREP00000030267	ptch2	ENSPREP00000030267	ENSPREP00000003071	Growth arrest-specific 1b.	Patched 2.	0.962
ENSPREP00000030267	shh	ENSPREP00000030267	ENSPREP00000013208	Growth arrest-specific 1b.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.809
ENSPREP00000033800	ENSPREP00000030267	ENSPREP00000033800	ENSPREP00000030267	Uncharacterized protein.	Growth arrest-specific 1b.	0.903
ENSPREP00000033800	Gas1	ENSPREP00000033800	ENSPREP00000013011	Uncharacterized protein.	Growth arrest-specific 1a.	0.903
ENSPREP00000033800	LOC103462620	ENSPREP00000033800	ENSPREP00000012147	Uncharacterized protein.	Uncharacterized protein.	0.903
ENSPREP00000033800	LOC103473569	ENSPREP00000033800	ENSPREP00000008924	Uncharacterized protein.	Uncharacterized protein.	0.900
ENSPREP00000033800	boc	ENSPREP00000033800	ENSPREP00000028078	Uncharacterized protein.	BOC cell adhesion associated, oncogene regulated.	0.903
ENSPREP00000033800	cdon	ENSPREP00000033800	ENSPREP00000024005	Uncharacterized protein.	Cell adhesion associated, oncogene regulated.	0.903
ENSPREP00000033800	lrp2	ENSPREP00000033800	ENSPREP00000004371	Uncharacterized protein.	Low density lipoprotein receptor-related protein 2a.	0.900
ENSPREP00000033800	ptch1	ENSPREP00000033800	ENSPREP00000024948	Uncharacterized protein.	Patched 1.	0.901
ENSPREP00000033800	ptch2	ENSPREP00000033800	ENSPREP00000003071	Uncharacterized protein.	Patched 2.	0.901
ENSPREP00000033800	shh	ENSPREP00000033800	ENSPREP00000013208	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.708

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001676

Long-chain fatty acid metabolic process

6 of 11

2.31

4.35

1.21e-09

GO:0032787

Monocarboxylic acid metabolic process

8 of 188

1.2

1.45

2.44e-06

GO:0044255

Cellular lipid metabolic process

7 of 158

1.22

1.37

1.53e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 4

2.27

1.01

0.0137

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016874

Ligase activity

8 of 137

1.34

1.85

2.41e-07

GO:0016405

CoA-ligase activity

3 of 10

2.05

1.44

0.0016

GO:0016878

Acid-thiol ligase activity

3 of 12

1.97

1.41

0.0017

GO:0016208

AMP binding

2 of 4

2.27

1.2

0.0059

GO:0003987

acetate-CoA ligase activity

2 of 4

2.27

1.2

0.0059

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4084

Long-chain fatty acid metabolic process, and Phosphate acyltransferases

4 of 7

2.33

2.9

2.28e-06

CL:3908

Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid metabolic process

7 of 95

1.44

1.92

1.44e-06

CL:5282

Mixed, incl. Sphingolipid metabolic process, and Helix-turn-helix XRE-family like proteins

2 of 6

2.09

0.85

0.0255

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0436

Ligase

8 of 92

1.51

2.54

3.37e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13193

AMP-binding enzyme C-terminal domain

7 of 10

2.41

5.93

5.40e-13

PF00501

AMP-binding enzyme

8 of 17

2.24

5.92

5.86e-14

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000873

AMP-dependent synthetase/ligase domain

8 of 17

2.24

5.76

1.54e-13

IPR025110

AMP-binding enzyme, C-terminal domain

7 of 10

2.41

5.75

1.42e-12

IPR045851

AMP-binding enzyme, C-terminal domain superfamily

7 of 12

2.34

5.51

2.44e-12

IPR020845

AMP-binding, conserved site

7 of 12

2.34

5.51

2.44e-12

IPR042099

ANL, N-terminal domain

7 of 16

2.21

5.08

7.11e-12

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