STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECTD4HECT domain E3 ubiquitin protein ligase 4. (4457 aa)    
Predicted Functional Partners:
EVC
EvC ciliary complex subunit 1.
   
 0.656
gga3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3a.
   
 
 0.637
LOC103461037
RAN binding protein 2.
   
 0.582
nek7
NIMA-related kinase 7; Belongs to the protein kinase superfamily.
    
 0.510
zfand4
Zinc finger, AN1-type domain 4.
    
 0.506
ND4
NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
    
 
 0.502
nup85
Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).
     
 0.487
brca1
Uncharacterized protein.
    
 0.457
LOC103474679
RAB guanine nucleotide exchange factor (GEF) 1, like.
    
 0.456
RABGEF1
RAB guanine nucleotide exchange factor 1.
    
 0.456
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.