ENSPREP00000012527 protein (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSPREP00000012527

Uncharacterized protein. (177 aa)

Predicted Functional Partners:

adm

0.985

LOC103461098

0.977

GNAS

0.939

LOC103464384

0.939

ENSPREP00000005770

0.861

LOC103475172

0.816

ENSPREP00000029608

0.816

RAMP3

0.652

LOC103466859

0.639

LOC103472245

0.639

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005770	ENSPREP00000012527	ENSPREP00000005770	ENSPREP00000012527	Uncharacterized protein.	Uncharacterized protein.	0.861
ENSPREP00000005770	ENSPREP00000029608	ENSPREP00000005770	ENSPREP00000029608	Uncharacterized protein.	CALCITONIN domain-containing protein.	0.492
ENSPREP00000005770	LOC103466859	ENSPREP00000005770	ENSPREP00000002047	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.645
ENSPREP00000005770	LOC103472245	ENSPREP00000005770	ENSPREP00000003824	Uncharacterized protein.	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	0.767
ENSPREP00000005770	RAMP3	ENSPREP00000005770	ENSPREP00000016240	Uncharacterized protein.	Receptor activity modifying protein 3.	0.823
ENSPREP00000012527	ENSPREP00000005770	ENSPREP00000012527	ENSPREP00000005770	Uncharacterized protein.	Uncharacterized protein.	0.861
ENSPREP00000012527	ENSPREP00000029608	ENSPREP00000012527	ENSPREP00000029608	Uncharacterized protein.	CALCITONIN domain-containing protein.	0.816
ENSPREP00000012527	GNAS	ENSPREP00000012527	ENSPREP00000001796	Uncharacterized protein.	GNAS complex locus.	0.939
ENSPREP00000012527	LOC103461098	ENSPREP00000012527	ENSPREP00000021873	Uncharacterized protein.	CALCITONIN domain-containing protein.	0.977
ENSPREP00000012527	LOC103464384	ENSPREP00000012527	ENSPREP00000013143	Uncharacterized protein.	GNAS complex locus.	0.939
ENSPREP00000012527	LOC103466859	ENSPREP00000012527	ENSPREP00000002047	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.639
ENSPREP00000012527	LOC103472245	ENSPREP00000012527	ENSPREP00000003824	Uncharacterized protein.	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	0.639
ENSPREP00000012527	LOC103475172	ENSPREP00000012527	ENSPREP00000004938	Uncharacterized protein.	CALCITONIN domain-containing protein.	0.816
ENSPREP00000012527	RAMP3	ENSPREP00000012527	ENSPREP00000016240	Uncharacterized protein.	Receptor activity modifying protein 3.	0.652
ENSPREP00000012527	adm	ENSPREP00000012527	ENSPREP00000034108	Uncharacterized protein.	Adrenomedullin a.	0.985
ENSPREP00000029608	ENSPREP00000005770	ENSPREP00000029608	ENSPREP00000005770	CALCITONIN domain-containing protein.	Uncharacterized protein.	0.492
ENSPREP00000029608	ENSPREP00000012527	ENSPREP00000029608	ENSPREP00000012527	CALCITONIN domain-containing protein.	Uncharacterized protein.	0.816
ENSPREP00000029608	GNAS	ENSPREP00000029608	ENSPREP00000001796	CALCITONIN domain-containing protein.	GNAS complex locus.	0.406
ENSPREP00000029608	LOC103461098	ENSPREP00000029608	ENSPREP00000021873	CALCITONIN domain-containing protein.	CALCITONIN domain-containing protein.	0.554
ENSPREP00000029608	LOC103464384	ENSPREP00000029608	ENSPREP00000013143	CALCITONIN domain-containing protein.	GNAS complex locus.	0.406

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.871

expected number of edges:

10

PPI enrichment p-value:

0.000306

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033198

Response to ATP

5 of 14

2.87

5.17

2.21e-10

GO:0032732

Positive regulation of interleukin-1 production

4 of 34

2.39

2.96

1.91e-06

GO:0035590

Purinergic nucleotide receptor signaling pathway

4 of 36

2.36

2.93

2.13e-06

GO:0006812

Cation transport

11 of 975

1.37

2.43

7.37e-12

GO:0002931

Response to ischemia

3 of 17

2.56

2.32

4.77e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035381

ATP-gated ion channel activity

3 of 9

2.84

2.91

4.43e-06

GO:0005261

Cation channel activity

8 of 469

1.55

2.69

2.02e-09

GO:0015267

Channel activity

9 of 648

1.46

2.54

3.54e-10

GO:0008324

Cation transmembrane transporter activity

10 of 823

1.4

2.42

1.11e-10

GO:0001614

Purinergic nucleotide receptor activity

3 of 23

2.43

2.31

4.41e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005639

Integral component of nuclear inner membrane

3 of 12

2.72

2.35

4.73e-05

GO:0005921

Gap junction

3 of 43

2.16

1.91

0.00020

GO:0005911

Cell-cell junction

4 of 389

1.33

0.99

0.0036

GO:0030054

Cell junction

6 of 1752

0.85

0.59

0.0082

GO:0120025

Plasma membrane bounded cell projection

6 of 1857

0.83

0.57

0.0091

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43862

Nucleotide receptor activity, and TMEM119 family

7 of 24

2.78

7.35

6.66e-15

CL:43865

ATP P2X receptor, and Innexin

5 of 10

3.02

5.6

4.43e-11

CL:43868

ATP P2X receptor

2 of 5

2.92

1.25

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04621

NOD-like receptor signaling pathway

3 of 133

1.67

1.09

0.0054

pret04020

Calcium signaling pathway

3 of 250

1.4

0.8

0.0172

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112307

Transmission across Electrical Synapses

3 of 10

2.79

2.4

3.93e-05

MAP-112303

Electric Transmission Across Gap Junctions

3 of 10

2.79

2.4

3.93e-05

MAP-139853

Elevation of cytosolic Ca2+ levels

3 of 21

2.47

2.16

9.24e-05

MAP-844456

The NLRP3 inflammasome

3 of 27

2.36

2.04

0.00014

MAP-9730628

Sensory perception of salty taste

2 of 2

3.32

1.96

0.00030

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005639

Integral component of nuclear inner membrane

3 of 11

2.75

2.36

4.60e-05

GOCC:0005921

Gap junction

3 of 38

2.21

1.8

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0407

Ion channel

6 of 308

1.61

2.26

9.31e-07

KW-0303

Gap junction

3 of 41

2.18

2.16

5.96e-05

KW-0325

Glycoprotein

3 of 61

2.01

1.91

0.00014

KW-1071

Ligand-gated ion channel

2 of 63

1.82

0.94

0.0144

KW-1133

Transmembrane helix

11 of 5706

0.6

0.54

2.64e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00876

Innexin

3 of 4

3.19

2.86

6.58e-06

PF00864

ATP P2X receptor

3 of 7

2.95

2.71

1.13e-05

PF14798

Calcium homeostasis modulator

2 of 5

2.92

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039099

Pannexin

3 of 4

3.19

2.59

2.05e-05

IPR000990

Innexin

3 of 4

3.19

2.59

2.05e-05

IPR027309

P2X purinoreceptor extracellular domain superfamily

3 of 7

2.95

2.54

2.35e-05

IPR001429

P2X purinoreceptor

3 of 7

2.95

2.54

2.35e-05

IPR029569

Calcium homeostasis modulator family

2 of 5

2.92

1.22

0.0063

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