LOC103479153 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103479153

Si:dkey-208k22.6. (553 aa)

Predicted Functional Partners:

LOC103466442

0.907

LOC103462420

0.907

LOC103473228

0.906

Cdk9

0.703

eaf2

0.654

eaf1

0.654

LOC103467752

0.650

LOC103463573

0.650

LOC103461629

0.650

ENSPREP00000016407

0.650

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk9	LOC103473228	ENSPREP00000011203	ENSPREP00000024130	Cyclin-dependent kinase 9 (CDC2-related kinase).	MARVEL domain containing 2a.	0.703
Cdk9	LOC103479153	ENSPREP00000011203	ENSPREP00000012804	Cyclin-dependent kinase 9 (CDC2-related kinase).	Si:dkey-208k22.6.	0.703
Cdk9	eaf1	ENSPREP00000011203	ENSPREP00000028293	Cyclin-dependent kinase 9 (CDC2-related kinase).	EAF domain-containing protein.	0.714
Cdk9	eaf2	ENSPREP00000011203	ENSPREP00000004928	Cyclin-dependent kinase 9 (CDC2-related kinase).	ELL associated factor 2.	0.707
ENSPREP00000016407	LOC103462420	ENSPREP00000016407	ENSPREP00000033787	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tight junction protein 1a; Belongs to the MAGUK family.	0.659
ENSPREP00000016407	LOC103466442	ENSPREP00000016407	ENSPREP00000022800	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tight junction protein 1b; Belongs to the MAGUK family.	0.659
ENSPREP00000016407	LOC103473228	ENSPREP00000016407	ENSPREP00000024130	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	MARVEL domain containing 2a.	0.650
ENSPREP00000016407	LOC103479153	ENSPREP00000016407	ENSPREP00000012804	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Si:dkey-208k22.6.	0.650
LOC103461629	LOC103462420	ENSPREP00000016342	ENSPREP00000033787	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tight junction protein 1a; Belongs to the MAGUK family.	0.659
LOC103461629	LOC103466442	ENSPREP00000016342	ENSPREP00000022800	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tight junction protein 1b; Belongs to the MAGUK family.	0.659
LOC103461629	LOC103473228	ENSPREP00000016342	ENSPREP00000024130	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	MARVEL domain containing 2a.	0.650
LOC103461629	LOC103479153	ENSPREP00000016342	ENSPREP00000012804	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Si:dkey-208k22.6.	0.650
LOC103462420	ENSPREP00000016407	ENSPREP00000033787	ENSPREP00000016407	Tight junction protein 1a; Belongs to the MAGUK family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.659
LOC103462420	LOC103461629	ENSPREP00000033787	ENSPREP00000016342	Tight junction protein 1a; Belongs to the MAGUK family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.659
LOC103462420	LOC103463573	ENSPREP00000033787	ENSPREP00000016233	Tight junction protein 1a; Belongs to the MAGUK family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.659
LOC103462420	LOC103466442	ENSPREP00000033787	ENSPREP00000022800	Tight junction protein 1a; Belongs to the MAGUK family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.902
LOC103462420	LOC103467752	ENSPREP00000033787	ENSPREP00000001773	Tight junction protein 1a; Belongs to the MAGUK family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.659
LOC103462420	LOC103473228	ENSPREP00000033787	ENSPREP00000024130	Tight junction protein 1a; Belongs to the MAGUK family.	MARVEL domain containing 2a.	0.937
LOC103462420	LOC103479153	ENSPREP00000033787	ENSPREP00000012804	Tight junction protein 1a; Belongs to the MAGUK family.	Si:dkey-208k22.6.	0.907
LOC103463573	LOC103462420	ENSPREP00000016233	ENSPREP00000033787	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tight junction protein 1a; Belongs to the MAGUK family.	0.659

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.905

expected number of edges:

17

PPI enrichment p-value:

0.0865

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032224

Positive regulation of synaptic transmission, cholinergic

3 of 5

3.1

2.82

7.57e-06

GO:0045995

Regulation of embryonic development

4 of 61

2.13

2.33

2.24e-05

GO:0000904

Cell morphogenesis involved in differentiation

7 of 515

1.45

1.89

2.56e-06

GO:0009887

Animal organ morphogenesis

8 of 749

1.35

1.74

1.71e-06

GO:0007411

Axon guidance

5 of 249

1.62

1.74

7.22e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005201

Extracellular matrix structural constituent

6 of 134

1.97

3.22

5.71e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005604

Basement membrane

8 of 77

2.33

6.55

5.35e-15

GO:0031012

Extracellular matrix

9 of 489

1.58

3.08

3.42e-11

GO:0043083

Synaptic cleft

3 of 9

2.84

2.95

3.81e-06

GO:0031594

Neuromuscular junction

3 of 44

2.15

1.86

0.00024

GO:0042383

Sarcolemma

3 of 77

1.91

1.49

0.0010

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36142434

(2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii).

3 of 13

2.68

2.39

3.80e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21899

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

8 of 14

3.07

10.0

1.42e-19

CL:21782

ECM-receptor interaction, and Laminin interactions

9 of 77

2.39

7.74

8.90e-18

CL:21901

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

4 of 7

3.07

4.56

4.34e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04512

ECM-receptor interaction

5 of 84

2.09

3.38

6.00e-08

pret04510

Focal adhesion

5 of 212

1.69

2.26

2.69e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000157

Laminin interactions

8 of 40

2.62

8.04

5.57e-17

MAP-8874081

MET activates PTK2 signaling

5 of 22

2.67

4.84

5.93e-10

MAP-8875878

MET promotes cell motility

5 of 38

2.44

4.23

4.69e-09

MAP-6806834

Signaling by MET

5 of 78

2.12

3.36

8.42e-08

MAP-3000171

Non-integrin membrane-ECM interactions

4 of 51

2.21

2.79

2.70e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

3 of 407

1.19

0.81

0.0076

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005604

Basement membrane

8 of 56

2.47

7.27

6.00e-16

GOCC:0062023

Collagen-containing extracellular matrix

9 of 190

1.99

5.33

9.90e-15

GOCC:0005610

laminin-5 complex

4 of 7

3.07

4.6

3.65e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0424

Laminin EGF-like domain

5 of 38

2.44

4.33

2.83e-09

KW-1015

Disulfide bond

5 of 1351

0.89

0.49

0.0415

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002049

Laminin-type EGF domain

6 of 51

2.39

4.58

5.94e-10

IPR000034

Laminin IV

4 of 6

3.14

4.2

2.16e-08

IPR008211

Laminin, N-terminal

4 of 23

2.56

3.14

1.20e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00180

Laminin-type epidermal growth factor-like domai

6 of 42

2.47

5.32

2.20e-11

SM00136

Laminin N-terminal domain (domain VI)

4 of 22

2.58

3.57

1.67e-07

SM00001

EGF domain, unclasssified subfamily

4 of 92

1.96

2.21

2.44e-05

SM00281

Laminin B domain

2 of 4

3.02

1.78

0.00061

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