hivep1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

hivep1

Human immunodeficiency virus type I enhancer binding protein 1. (2369 aa)

Predicted Functional Partners:

AIF1

0.515

aif1l

0.515

setbp1

0.489

arid4b

0.447

LOC103473071

0.431

trip11

0.418

zmym2

0.412

LOC103469229

0.410

phf21a

0.402

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	hivep1	ENSPREP00000003783	ENSPREP00000012907	Allograft inflammatory factor 1.	Human immunodeficiency virus type I enhancer binding protein 1.	0.515
LOC103469229	hivep1	ENSPREP00000009032	ENSPREP00000012907	Chromobox homolog 4 (Pc class homolog, Drosophila).	Human immunodeficiency virus type I enhancer binding protein 1.	0.410
LOC103469229	setbp1	ENSPREP00000009032	ENSPREP00000003644	Chromobox homolog 4 (Pc class homolog, Drosophila).	SET binding protein 1.	0.477
LOC103473071	hivep1	ENSPREP00000014705	ENSPREP00000012907	Thyroid hormone receptor associated protein 3b.	Human immunodeficiency virus type I enhancer binding protein 1.	0.431
LOC103473071	setbp1	ENSPREP00000014705	ENSPREP00000003644	Thyroid hormone receptor associated protein 3b.	SET binding protein 1.	0.499
LOC103473071	trip11	ENSPREP00000014705	ENSPREP00000028241	Thyroid hormone receptor associated protein 3b.	Thyroid hormone receptor interactor 11.	0.521
aif1l	hivep1	ENSPREP00000032076	ENSPREP00000012907	Allograft inflammatory factor 1-like.	Human immunodeficiency virus type I enhancer binding protein 1.	0.515
arid4b	hivep1	ENSPREP00000011747	ENSPREP00000012907	Translocase of outer mitochondrial membrane 20.	Human immunodeficiency virus type I enhancer binding protein 1.	0.447
arid4b	phf21a	ENSPREP00000011747	ENSPREP00000030809	Translocase of outer mitochondrial membrane 20.	PHD finger protein 21Ab.	0.748
arid4b	setbp1	ENSPREP00000011747	ENSPREP00000003644	Translocase of outer mitochondrial membrane 20.	SET binding protein 1.	0.542
arid4b	zmym2	ENSPREP00000011747	ENSPREP00000001605	Translocase of outer mitochondrial membrane 20.	Zinc finger, MYM-type 2.	0.413
hivep1	AIF1	ENSPREP00000012907	ENSPREP00000003783	Human immunodeficiency virus type I enhancer binding protein 1.	Allograft inflammatory factor 1.	0.515
hivep1	LOC103469229	ENSPREP00000012907	ENSPREP00000009032	Human immunodeficiency virus type I enhancer binding protein 1.	Chromobox homolog 4 (Pc class homolog, Drosophila).	0.410
hivep1	LOC103473071	ENSPREP00000012907	ENSPREP00000014705	Human immunodeficiency virus type I enhancer binding protein 1.	Thyroid hormone receptor associated protein 3b.	0.431
hivep1	aif1l	ENSPREP00000012907	ENSPREP00000032076	Human immunodeficiency virus type I enhancer binding protein 1.	Allograft inflammatory factor 1-like.	0.515
hivep1	arid4b	ENSPREP00000012907	ENSPREP00000011747	Human immunodeficiency virus type I enhancer binding protein 1.	Translocase of outer mitochondrial membrane 20.	0.447
hivep1	phf21a	ENSPREP00000012907	ENSPREP00000030809	Human immunodeficiency virus type I enhancer binding protein 1.	PHD finger protein 21Ab.	0.402
hivep1	setbp1	ENSPREP00000012907	ENSPREP00000003644	Human immunodeficiency virus type I enhancer binding protein 1.	SET binding protein 1.	0.489
hivep1	trip11	ENSPREP00000012907	ENSPREP00000028241	Human immunodeficiency virus type I enhancer binding protein 1.	Thyroid hormone receptor interactor 11.	0.418
hivep1	zmym2	ENSPREP00000012907	ENSPREP00000001605	Human immunodeficiency virus type I enhancer binding protein 1.	Zinc finger, MYM-type 2.	0.412

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

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