STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nr0b2Nuclear receptor subfamily 0, group B, member 2a. (260 aa)    
Predicted Functional Partners:
ENSPREP00000011180
Nuclear receptor subfamily 5, group A, member 2.
   
 0.945
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
   
 0.687
PPARA
Peroxisome proliferator-activated receptor alpha b.
   
 0.686
LOC103456526
Hepatocyte nuclear factor 4, gamma.
   
0.671
hnf4a
Hepatocyte nuclear factor 4, alpha.
   
0.671
ppara
Peroxisome proliferator-activated receptor alpha a.
   
 0.649
ncor2
Nuclear receptor corepressor 2.
    
 0.647
ncor1
Nuclear receptor corepressor 1.
    
 0.647
LOC103470136
cAMP responsive element binding protein 3-like 3 like.
      
 0.644
LOC103467002
Nuclear receptor subfamily 1, group H, member 5.
   
 
 0.642
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.