STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103459498Cyclin-dependent kinase inhibitor 1D. (179 aa)    
Predicted Functional Partners:
skp2
F-box domain-containing protein.
    
 0.831
ccne1
Cyclin E1; Belongs to the cyclin family.
   
 0.807
ccne2
Cyclin E2; Belongs to the cyclin family.
   
 0.807
cul1
Cullin 1b; Belongs to the cullin family.
    
 0.767
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 0.761
ccna2
Cyclin A2; Belongs to the cyclin family.
    
 0.744
ccna1
Cyclin A1; Belongs to the cyclin family.
    
 0.744
rps27a
Ribosomal protein S27a.
   
  0.710
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.693
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
  0.683
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.