carnmt1 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

carnmt1

Carnosine N-methyltransferase 1. (408 aa)

Predicted Functional Partners:

cndp2

0.915

LOC103472482

0.915

LOC103460253

0.549

garnl3

0.549

psmd14

0.548

DONSON

0.545

tbrg1

0.539

setd3

0.534

mgme1

0.529

gramd1b

0.475

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DONSON	carnmt1	ENSPREP00000027215	ENSPREP00000014001	Downstream neighbor of SON.	Carnosine N-methyltransferase 1.	0.545
DONSON	mgme1	ENSPREP00000027215	ENSPREP00000009744	Downstream neighbor of SON.	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family.	0.414
LOC103460253	carnmt1	ENSPREP00000019943	ENSPREP00000014001	Uncharacterized protein.	Carnosine N-methyltransferase 1.	0.549
LOC103460253	mgme1	ENSPREP00000019943	ENSPREP00000009744	Uncharacterized protein.	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family.	0.549
LOC103472482	carnmt1	ENSPREP00000018149	ENSPREP00000014001	Carnosine dipeptidase 2.	Carnosine N-methyltransferase 1.	0.915
LOC103472482	cndp2	ENSPREP00000018149	ENSPREP00000018109	Carnosine dipeptidase 2.	M20_dimer domain-containing protein.	0.901
carnmt1	DONSON	ENSPREP00000014001	ENSPREP00000027215	Carnosine N-methyltransferase 1.	Downstream neighbor of SON.	0.545
carnmt1	LOC103460253	ENSPREP00000014001	ENSPREP00000019943	Carnosine N-methyltransferase 1.	Uncharacterized protein.	0.549
carnmt1	LOC103472482	ENSPREP00000014001	ENSPREP00000018149	Carnosine N-methyltransferase 1.	Carnosine dipeptidase 2.	0.915
carnmt1	cndp2	ENSPREP00000014001	ENSPREP00000018109	Carnosine N-methyltransferase 1.	M20_dimer domain-containing protein.	0.915
carnmt1	garnl3	ENSPREP00000014001	ENSPREP00000032268	Carnosine N-methyltransferase 1.	GTPase activating Rap/RanGAP domain like 3.	0.549
carnmt1	gramd1b	ENSPREP00000014001	ENSPREP00000006370	Carnosine N-methyltransferase 1.	GRAM domain containing 1Bb.	0.475
carnmt1	mgme1	ENSPREP00000014001	ENSPREP00000009744	Carnosine N-methyltransferase 1.	Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family.	0.529
carnmt1	psmd14	ENSPREP00000014001	ENSPREP00000029743	Carnosine N-methyltransferase 1.	Proteasome 26S subunit, non-ATPase 14.	0.548
carnmt1	setd3	ENSPREP00000014001	ENSPREP00000017405	Carnosine N-methyltransferase 1.	Protein-histidine N-methyltransferase.	0.534
carnmt1	tbrg1	ENSPREP00000014001	ENSPREP00000007678	Carnosine N-methyltransferase 1.	Transforming growth factor beta regulator 1.	0.539
cndp2	LOC103472482	ENSPREP00000018109	ENSPREP00000018149	M20_dimer domain-containing protein.	Carnosine dipeptidase 2.	0.901
cndp2	carnmt1	ENSPREP00000018109	ENSPREP00000014001	M20_dimer domain-containing protein.	Carnosine N-methyltransferase 1.	0.915
garnl3	carnmt1	ENSPREP00000032268	ENSPREP00000014001	GTPase activating Rap/RanGAP domain like 3.	Carnosine N-methyltransferase 1.	0.549
garnl3	gramd1b	ENSPREP00000032268	ENSPREP00000006370	GTPase activating Rap/RanGAP domain like 3.	GRAM domain containing 1Bb.	0.475

page 1 of 2

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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