STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103477293Fibroblast growth factor receptor. (676 aa)    
Predicted Functional Partners:
sos1
Son of sevenless homolog 1 (Drosophila).
    
 0.946
sos2
Son of sevenless homolog 2 (Drosophila).
    
 0.946
fgf1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.930
grb2
Growth factor receptor-bound protein 2b.
   
 0.928
LOC103476521
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.924
Fgf20
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.909
fgf23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
    
 0.903
fgf2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.885
fgf19
Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.
    
 0.880
fgf7
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.870
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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