MEGF11 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MEGF11

Multiple EGF like domains 11. (1026 aa)

Predicted Functional Partners:

ppp2ca

0.560

adcy7

0.560

CSK

0.554

gulp1

0.544

Gas1

0.495

LOC103460107

0.486

skp1

0.475

ENSPREP00000014846

0.457

Lama2

0.457

ENSPREP00000014939

0.457

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSK	MEGF11	ENSPREP00000012179	ENSPREP00000014169	Tyrosine-protein kinase.	Multiple EGF like domains 11.	0.554
CSK	adcy7	ENSPREP00000012179	ENSPREP00000010389	Tyrosine-protein kinase.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.436
CSK	ppp2ca	ENSPREP00000012179	ENSPREP00000007606	Tyrosine-protein kinase.	Serine/threonine-protein phosphatase.	0.558
CSK	skp1	ENSPREP00000012179	ENSPREP00000007574	Tyrosine-protein kinase.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.452
ENSPREP00000014846	ENSPREP00000014939	ENSPREP00000014846	ENSPREP00000014939	Uncharacterized protein.	Uncharacterized protein.	0.921
ENSPREP00000014846	Lama2	ENSPREP00000014846	ENSPREP00000014859	Uncharacterized protein.	Laminin_I domain-containing protein.	0.900
ENSPREP00000014846	MEGF11	ENSPREP00000014846	ENSPREP00000014169	Uncharacterized protein.	Multiple EGF like domains 11.	0.457
ENSPREP00000014939	ENSPREP00000014846	ENSPREP00000014939	ENSPREP00000014846	Uncharacterized protein.	Uncharacterized protein.	0.921
ENSPREP00000014939	Lama2	ENSPREP00000014939	ENSPREP00000014859	Uncharacterized protein.	Laminin_I domain-containing protein.	0.899
ENSPREP00000014939	MEGF11	ENSPREP00000014939	ENSPREP00000014169	Uncharacterized protein.	Multiple EGF like domains 11.	0.457
Gas1	MEGF11	ENSPREP00000013011	ENSPREP00000014169	Growth arrest-specific 1a.	Multiple EGF like domains 11.	0.495
LOC103460107	MEGF11	ENSPREP00000014136	ENSPREP00000014169	RAB11a, member RAS oncogene family.	Multiple EGF like domains 11.	0.486
LOC103460107	adcy7	ENSPREP00000014136	ENSPREP00000010389	RAB11a, member RAS oncogene family.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.407
LOC103460107	ppp2ca	ENSPREP00000014136	ENSPREP00000007606	RAB11a, member RAS oncogene family.	Serine/threonine-protein phosphatase.	0.467
Lama2	ENSPREP00000014846	ENSPREP00000014859	ENSPREP00000014846	Laminin_I domain-containing protein.	Uncharacterized protein.	0.900
Lama2	ENSPREP00000014939	ENSPREP00000014859	ENSPREP00000014939	Laminin_I domain-containing protein.	Uncharacterized protein.	0.899
Lama2	MEGF11	ENSPREP00000014859	ENSPREP00000014169	Laminin_I domain-containing protein.	Multiple EGF like domains 11.	0.457
MEGF11	CSK	ENSPREP00000014169	ENSPREP00000012179	Multiple EGF like domains 11.	Tyrosine-protein kinase.	0.554
MEGF11	ENSPREP00000014846	ENSPREP00000014169	ENSPREP00000014846	Multiple EGF like domains 11.	Uncharacterized protein.	0.457
MEGF11	ENSPREP00000014939	ENSPREP00000014169	ENSPREP00000014939	Multiple EGF like domains 11.	Uncharacterized protein.	0.457

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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