ENSPREP00000015423 protein (Poecilia reticulata)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ENSPREP00000015423

FYVE domain-containing protein. (73 aa)

Predicted Functional Partners:

SMAD3

0.954

LOC103466539

0.954

LOC103469777

0.954

LOC103473219

0.900

zfyve9

0.900

LOC103473773

0.605

LOC103477474

0.605

SMAD4

0.605

ptpn23

0.575

LOC103471035

0.568

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000015423	LOC103466539	ENSPREP00000015423	ENSPREP00000015844	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.954
ENSPREP00000015423	LOC103469777	ENSPREP00000015423	ENSPREP00000025545	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.954
ENSPREP00000015423	LOC103471035	ENSPREP00000015423	ENSPREP00000005305	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.568
ENSPREP00000015423	LOC103473219	ENSPREP00000015423	ENSPREP00000023134	FYVE domain-containing protein.	Zinc finger, FYVE domain containing 16.	0.900
ENSPREP00000015423	LOC103473773	ENSPREP00000015423	ENSPREP00000020499	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.605
ENSPREP00000015423	LOC103477474	ENSPREP00000015423	ENSPREP00000022544	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.605
ENSPREP00000015423	SMAD3	ENSPREP00000015423	ENSPREP00000012114	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.954
ENSPREP00000015423	SMAD4	ENSPREP00000015423	ENSPREP00000027467	FYVE domain-containing protein.	Mothers against decapentaplegic homolog.	0.605
ENSPREP00000015423	ptpn23	ENSPREP00000015423	ENSPREP00000029531	FYVE domain-containing protein.	Protein tyrosine phosphatase, non-receptor type 23, a.	0.575
ENSPREP00000015423	zfyve9	ENSPREP00000015423	ENSPREP00000026344	FYVE domain-containing protein.	Zinc finger, FYVE domain containing 9a.	0.900
LOC103466539	ENSPREP00000015423	ENSPREP00000015844	ENSPREP00000015423	Mothers against decapentaplegic homolog.	FYVE domain-containing protein.	0.954
LOC103466539	LOC103469777	ENSPREP00000015844	ENSPREP00000025545	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103466539	LOC103471035	ENSPREP00000015844	ENSPREP00000005305	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.413
LOC103466539	LOC103473219	ENSPREP00000015844	ENSPREP00000023134	Mothers against decapentaplegic homolog.	Zinc finger, FYVE domain containing 16.	0.961
LOC103466539	LOC103473773	ENSPREP00000015844	ENSPREP00000020499	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.971
LOC103466539	LOC103477474	ENSPREP00000015844	ENSPREP00000022544	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.971
LOC103466539	SMAD3	ENSPREP00000015844	ENSPREP00000012114	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
LOC103466539	SMAD4	ENSPREP00000015844	ENSPREP00000027467	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.736
LOC103466539	zfyve9	ENSPREP00000015844	ENSPREP00000026344	Mothers against decapentaplegic homolog.	Zinc finger, FYVE domain containing 9a.	0.961
LOC103469777	ENSPREP00000015423	ENSPREP00000025545	ENSPREP00000015423	Mothers against decapentaplegic homolog.	FYVE domain-containing protein.	0.954

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

8 of 941

1.07

1.08

7.32e-05

GO:0006470

Protein dephosphorylation

3 of 67

1.8

1.07

0.0074

GO:0036211

Protein modification process

7 of 1176

0.92

0.7

0.0034

GO:0006468

Protein phosphorylation

4 of 415

1.13

0.57

0.0437

GO:1901564

Organonitrogen compound metabolic process

8 of 2532

0.64

0.41

0.0241

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017018

Myosin phosphatase activity

3 of 45

1.97

1.16

0.0058

GO:0140096

Catalytic activity, acting on a protein

7 of 1272

0.89

0.64

0.0058

GO:0004672

Protein kinase activity

4 of 415

1.13

0.59

0.0390

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. GDP metabolic process, and Signaling receptor complex adaptor activity

3 of 5

2.92

2.59

1.88e-05

CL:1988

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

4 of 32

2.24

2.42

1.88e-05

CL:1900

Mixed, incl. Serine/threonine-protein kinase, and MAPK cascade

5 of 137

1.71

2.01

2.10e-05

CL:1990

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

3 of 26

2.21

1.84

0.00029

CL:13390

Cyclic nucleotide-dependent protein kinase activity, and PPM-type phosphatase, divalent cation binding

2 of 6

2.67

1.43

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

8 of 394

1.45

2.15

1.07e-07

IPR011009

Protein kinase-like domain superfamily

8 of 431

1.41

2.07

1.08e-07

IPR036457

PPM-type phosphatase-like domain superfamily

3 of 30

2.14

1.45

0.0017

IPR001932

PPM-type phosphatase-like domain

3 of 30

2.14

1.45

0.0017

IPR000222

PPM-type phosphatase, divalent cation binding

2 of 12

2.37

0.84

0.0285

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00331

Sigma factor PP2C-like phosphatases

2 of 22

2.1

0.73

0.0449

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