LOC108166865 protein (Poecilia reticulata) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC108166865

ZnMc domain-containing protein. (473 aa)

Predicted Functional Partners:

LOC103468846

0.547

LOC103481516

0.547

TIMP3

0.547

timp4

0.440

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103468846	LOC108166865	ENSPREP00000003545	ENSPREP00000015586	TIMP metallopeptidase inhibitor 2b.	ZnMc domain-containing protein.	0.547
LOC103468846	TIMP3	ENSPREP00000003545	ENSPREP00000023839	TIMP metallopeptidase inhibitor 2b.	TIMP metallopeptidase inhibitor 3.	0.491
LOC103481516	LOC108166865	ENSPREP00000005517	ENSPREP00000015586	TIMP metallopeptidase inhibitor 2a.	ZnMc domain-containing protein.	0.547
LOC103481516	TIMP3	ENSPREP00000005517	ENSPREP00000023839	TIMP metallopeptidase inhibitor 2a.	TIMP metallopeptidase inhibitor 3.	0.510
LOC108166865	LOC103468846	ENSPREP00000015586	ENSPREP00000003545	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 2b.	0.547
LOC108166865	LOC103481516	ENSPREP00000015586	ENSPREP00000005517	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 2a.	0.547
LOC108166865	TIMP3	ENSPREP00000015586	ENSPREP00000023839	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 3.	0.547
LOC108166865	timp4	ENSPREP00000015586	ENSPREP00000009410	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 4, tandem duplicate 1.	0.440
TIMP3	LOC103468846	ENSPREP00000023839	ENSPREP00000003545	TIMP metallopeptidase inhibitor 3.	TIMP metallopeptidase inhibitor 2b.	0.491
TIMP3	LOC103481516	ENSPREP00000023839	ENSPREP00000005517	TIMP metallopeptidase inhibitor 3.	TIMP metallopeptidase inhibitor 2a.	0.510
TIMP3	LOC108166865	ENSPREP00000023839	ENSPREP00000015586	TIMP metallopeptidase inhibitor 3.	ZnMc domain-containing protein.	0.547
timp4	LOC108166865	ENSPREP00000009410	ENSPREP00000015586	TIMP metallopeptidase inhibitor 4, tandem duplicate 1.	ZnMc domain-containing protein.	0.440

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

4.32e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007059

Chromosome segregation

8 of 207

1.9

4.01

7.01e-11

GO:0098813

Nuclear chromosome segregation

7 of 158

1.96

3.78

1.17e-09

GO:0000819

Sister chromatid segregation

5 of 106

1.99

2.77

1.12e-06

GO:0007051

Spindle organization

5 of 123

1.93

2.62

1.85e-06

GO:0022402

Cell cycle process

9 of 624

1.48

2.52

1.28e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008017

Microtubule binding

5 of 271

1.58

1.52

0.00029

GO:0008574

Plus-end-directed microtubule motor activity

2 of 21

2.3

0.72

0.0473

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005819

Spindle

8 of 290

1.76

3.51

1.52e-10

GO:0000775

Chromosome, centromeric region

5 of 140

1.87

2.5

2.55e-06

GO:0000776

Kinetochore

4 of 94

1.95

2.22

2.15e-05

GO:0072686

Mitotic spindle

4 of 116

1.86

2.11

2.65e-05

GO:0000922

Spindle pole

4 of 122

1.83

2.08

2.95e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25538793

(2014) Genes on B chromosomes of vertebrates.

2 of 14

2.47

0.92

0.0207

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8086

Mixed, incl. Spindle elongation, and Chromosome passenger complex

8 of 29

2.76

8.54

1.71e-17

CL:8090

Mixed, incl. Mitotic spindle midzone, and Spindle elongation

6 of 13

2.98

7.24

2.62e-14

CL:7890

Mixed, incl. Mitotic cell cycle phase transition, and Mitotic sister chromatid segregation

9 of 163

2.06

5.77

2.12e-15

CL:8093

Mixed, incl. Cenp-F N-terminal domain, and TSG101 and ALIX binding domain of CEP55

4 of 5

3.22

4.87

1.30e-09

CL:13082

Mixed, incl. Abr/Bcr, and Rho GTPase-activating protein 11

2 of 10

2.62

1.28

0.0046

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04110

Cell cycle

3 of 120

1.72

1.16

0.0040

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-141444

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

4 of 102

1.91

1.89

0.00012

MAP-141424

Amplification of signal from the kinetochores

4 of 102

1.91

1.89

0.00012

MAP-69618

Mitotic Spindle Checkpoint

4 of 132

1.8

1.82

0.00012

MAP-9648025

EML4 and NUDC in mitotic spindle formation

4 of 156

1.73

1.71

0.00017

MAP-2467813

Separation of Sister Chromatids

5 of 244

1.63

1.69

0.00011

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005819

Spindle

7 of 117

2.09

4.5

5.76e-11

GOCC:0015630

Microtubule cytoskeleton

8 of 556

1.48

2.35

1.54e-08

GOCC:0000793

Condensed chromosome

4 of 110

1.88

2.05

4.27e-05

GOCC:0000922

Spindle pole

3 of 50

2.1

1.76

0.00037

GOCC:0000779

Condensed chromosome, centromeric region

3 of 50

2.1

1.76

0.00037

(more ...)

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