LOC103468956 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:

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Score

LOC103468956

Uncharacterized protein. (206 aa)

Predicted Functional Partners:

ENSPREP00000013716

0.795

ENSPREP00000027294

0.792

Cldn5

0.782

LOC103460590

0.748

LOC103480588

0.746

LOC103475300

0.734

ENSPREP00000026663

0.733

ENSPREP00000026018

0.731

cldn15

0.725

LOC103479092

0.696

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cldn5	ENSPREP00000013716	ENSPREP00000017247	ENSPREP00000013716	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.701
Cldn5	ENSPREP00000026018	ENSPREP00000017247	ENSPREP00000026018	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.754
Cldn5	ENSPREP00000026663	ENSPREP00000017247	ENSPREP00000026663	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.679
Cldn5	ENSPREP00000027294	ENSPREP00000017247	ENSPREP00000027294	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.697
Cldn5	LOC103460590	ENSPREP00000017247	ENSPREP00000005394	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.676
Cldn5	LOC103468956	ENSPREP00000017247	ENSPREP00000015777	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.782
Cldn5	LOC103475300	ENSPREP00000017247	ENSPREP00000004640	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.687
Cldn5	LOC103479092	ENSPREP00000017247	ENSPREP00000010324	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.749
Cldn5	LOC103480588	ENSPREP00000017247	ENSPREP00000023093	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.725
Cldn5	cldn15	ENSPREP00000017247	ENSPREP00000016232	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.677
ENSPREP00000013716	Cldn5	ENSPREP00000013716	ENSPREP00000017247	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.701
ENSPREP00000013716	ENSPREP00000026018	ENSPREP00000013716	ENSPREP00000026018	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.650
ENSPREP00000013716	ENSPREP00000026663	ENSPREP00000013716	ENSPREP00000026663	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
ENSPREP00000013716	ENSPREP00000027294	ENSPREP00000013716	ENSPREP00000027294	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.655
ENSPREP00000013716	LOC103460590	ENSPREP00000013716	ENSPREP00000005394	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
ENSPREP00000013716	LOC103468956	ENSPREP00000013716	ENSPREP00000015777	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.795
ENSPREP00000013716	LOC103475300	ENSPREP00000013716	ENSPREP00000004640	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.694
ENSPREP00000013716	LOC103479092	ENSPREP00000013716	ENSPREP00000010324	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.725
ENSPREP00000013716	LOC103480588	ENSPREP00000013716	ENSPREP00000023093	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.713
ENSPREP00000013716	cldn15	ENSPREP00000013716	ENSPREP00000016232	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664

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Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

0.232

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

9 of 175

2.03

5.27

5.11e-14

GO:0046486

Glycerolipid metabolic process

10 of 342

1.78

4.32

5.11e-14

GO:0006629

Lipid metabolic process

11 of 1175

1.29

2.15

1.13e-11

GO:0045017

Glycerolipid biosynthetic process

5 of 205

1.7

2.0

2.23e-05

GO:0043647

Inositol phosphate metabolic process

3 of 34

2.26

1.8

0.00037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004435

Phosphatidylinositol phospholipase C activity

4 of 24

2.54

3.22

7.90e-07

GO:0042578

Phosphoric ester hydrolase activity

8 of 473

1.55

2.52

1.51e-08

GO:0046030

Inositol trisphosphate phosphatase activity

2 of 17

2.39

1.12

0.0087

GO:0016791

Phosphatase activity

4 of 351

1.37

0.99

0.0046

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 45

1.97

0.71

0.0463

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27029

Inositol phosphate metabolism, and Inositol hexakisphosphate 5-kinase activity

9 of 84

2.35

7.32

5.58e-17

CL:27030

Inositol phosphate metabolism

8 of 67

2.39

6.88

1.86e-15

CL:27032

Inositol phosphate metabolism

7 of 45

2.51

6.48

6.76e-14

CL:27033

Inositol phosphate metabolism

6 of 39

2.5

5.46

1.34e-11

CL:27060

Mixed, incl. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain, and 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain

4 of 10

2.92

4.19

1.81e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret00562

Inositol phosphate metabolism

11 of 82

2.45

10.56

4.53e-25

pret04070

Phosphatidylinositol signaling system

11 of 88

2.41

10.39

4.68e-25

pret01100

Metabolic pathways

11 of 1488

1.19

1.85

5.14e-12

pret04020

Calcium signaling pathway

4 of 250

1.52

0.00019

pret04370

VEGF signaling pathway

2 of 64

1.81

0.94

0.0147

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

8 of 73

2.36

6.63

4.73e-15

MAP-1855204

Synthesis of IP3 and IP4 in the cytosol

5 of 45

2.36

3.92

1.55e-08

MAP-1660517

Synthesis of PIPs at the late endosome membrane

2 of 7

2.77

1.38

0.0031

MAP-202403

TCR signaling

3 of 80

1.89

1.27

0.0031

MAP-1660516

Synthesis of PIPs at the early endosome membrane

2 of 15

2.44

1.18

0.0068

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

5 of 102

2.01

3.0

3.08e-07

KW-0442

Lipid degradation

3 of 45

2.14

1.86

0.00024

KW-0378

Hydrolase

5 of 768

1.13

0.92

0.0019

KW-0807

Transducer

4 of 562

1.17

0.79

0.0089

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001711

Phospholipase C, phosphatidylinositol-specific, Y domain

4 of 23

2.56

2.9

3.59e-06

IPR001192

Phosphoinositide phospholipase C family

4 of 23

2.56

2.9

3.59e-06

IPR000909

Phosphatidylinositol-specific phospholipase C, X domain

4 of 29

2.46

2.86

3.59e-06

IPR017946

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

4 of 40

2.32

2.66

6.91e-06

IPR035892

C2 domain superfamily

5 of 228

1.66

1.79

6.56e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00149

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00148

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 185

1.65

1.53

0.00037

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