LOC103462782 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103462782

GC-rich sequence DNA-binding factor 2. (843 aa)

Predicted Functional Partners:

tfip11

0.823

DHX15

0.794

syf2

0.734

cdc40

0.706

LOC103480693

0.680

ppil1

0.669

LOC103474722

0.588

LOC103481567

0.565

dqx1

0.565

LOC103476760

0.565

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHX15	LOC103462782	ENSPREP00000006773	ENSPREP00000015935	DEAH-box helicase 15.	GC-rich sequence DNA-binding factor 2.	0.794
DHX15	LOC103480693	ENSPREP00000006773	ENSPREP00000028442	DEAH-box helicase 15.	DEAH (Asp-Glu-Ala-His) box helicase 15.	0.900
DHX15	cdc40	ENSPREP00000006773	ENSPREP00000003161	DEAH-box helicase 15.	Cell division cycle 40 homolog (S. cerevisiae).	0.969
DHX15	ppil1	ENSPREP00000006773	ENSPREP00000002465	DEAH-box helicase 15.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.845
DHX15	syf2	ENSPREP00000006773	ENSPREP00000004254	DEAH-box helicase 15.	SYF2 pre-mRNA-splicing factor.	0.952
DHX15	tfip11	ENSPREP00000006773	ENSPREP00000002431	DEAH-box helicase 15.	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family.	0.984
LOC103462782	DHX15	ENSPREP00000015935	ENSPREP00000006773	GC-rich sequence DNA-binding factor 2.	DEAH-box helicase 15.	0.794
LOC103462782	LOC103474722	ENSPREP00000015935	ENSPREP00000033244	GC-rich sequence DNA-binding factor 2.	Uncharacterized protein.	0.588
LOC103462782	LOC103476760	ENSPREP00000015935	ENSPREP00000017352	GC-rich sequence DNA-binding factor 2.	DEAH (Asp-Glu-Ala-His) box polypeptide 32b.	0.565
LOC103462782	LOC103480693	ENSPREP00000015935	ENSPREP00000028442	GC-rich sequence DNA-binding factor 2.	DEAH (Asp-Glu-Ala-His) box helicase 15.	0.680
LOC103462782	LOC103481567	ENSPREP00000015935	ENSPREP00000009771	GC-rich sequence DNA-binding factor 2.	DEAH (Asp-Glu-Ala-His) box polypeptide 32a.	0.565
LOC103462782	cdc40	ENSPREP00000015935	ENSPREP00000003161	GC-rich sequence DNA-binding factor 2.	Cell division cycle 40 homolog (S. cerevisiae).	0.706
LOC103462782	dqx1	ENSPREP00000015935	ENSPREP00000010522	GC-rich sequence DNA-binding factor 2.	DEAQ box RNA-dependent ATPase 1.	0.565
LOC103462782	ppil1	ENSPREP00000015935	ENSPREP00000002465	GC-rich sequence DNA-binding factor 2.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.669
LOC103462782	syf2	ENSPREP00000015935	ENSPREP00000004254	GC-rich sequence DNA-binding factor 2.	SYF2 pre-mRNA-splicing factor.	0.734
LOC103462782	tfip11	ENSPREP00000015935	ENSPREP00000002431	GC-rich sequence DNA-binding factor 2.	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family.	0.823
LOC103474722	LOC103462782	ENSPREP00000033244	ENSPREP00000015935	Uncharacterized protein.	GC-rich sequence DNA-binding factor 2.	0.588
LOC103474722	tfip11	ENSPREP00000033244	ENSPREP00000002431	Uncharacterized protein.	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family.	0.686
LOC103476760	LOC103462782	ENSPREP00000017352	ENSPREP00000015935	DEAH (Asp-Glu-Ala-His) box polypeptide 32b.	GC-rich sequence DNA-binding factor 2.	0.565
LOC103476760	cdc40	ENSPREP00000017352	ENSPREP00000003161	DEAH (Asp-Glu-Ala-His) box polypeptide 32b.	Cell division cycle 40 homolog (S. cerevisiae).	0.741

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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