LOC103480528 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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[Homology]

Score

LOC103480528

DnaJ (Hsp40) homolog, subfamily C, member 3b. (501 aa)

Predicted Functional Partners:

hsp90b1

0.809

hspa5

0.784

pdia6

0.772

sec63

0.724

hyou1

0.690

Ankrd45

0.676

xbp1

0.660

hspa9

0.647

dnajb11

0.629

dnajc10

0.604

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd45	LOC103480528	ENSPREP00000022246	ENSPREP00000016273	ANK_REP_REGION domain-containing protein.	DnaJ (Hsp40) homolog, subfamily C, member 3b.	0.676
Ankrd45	dnajb11	ENSPREP00000022246	ENSPREP00000028523	ANK_REP_REGION domain-containing protein.	DnaJ heat shock protein family (Hsp40) member B11.	0.681
Ankrd45	dnajc10	ENSPREP00000022246	ENSPREP00000031100	ANK_REP_REGION domain-containing protein.	DnaJ (Hsp40) homolog, subfamily C, member 10.	0.985
Ankrd45	hsp90b1	ENSPREP00000022246	ENSPREP00000005847	ANK_REP_REGION domain-containing protein.	Heat shock protein 90, beta (grp94), member 1.	0.962
Ankrd45	hspa9	ENSPREP00000022246	ENSPREP00000001232	ANK_REP_REGION domain-containing protein.	Heat shock protein 9; Belongs to the heat shock protein 70 family.	0.755
Ankrd45	hyou1	ENSPREP00000022246	ENSPREP00000020322	ANK_REP_REGION domain-containing protein.	Hypoxia up-regulated 1.	0.975
Ankrd45	pdia6	ENSPREP00000022246	ENSPREP00000009774	ANK_REP_REGION domain-containing protein.	Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family.	0.570
Ankrd45	sec63	ENSPREP00000022246	ENSPREP00000016978	ANK_REP_REGION domain-containing protein.	SEC63 homolog, protein translocation regulator.	0.957
Ankrd45	xbp1	ENSPREP00000022246	ENSPREP00000006543	ANK_REP_REGION domain-containing protein.	X-box binding protein 1.	0.608
LOC103480528	Ankrd45	ENSPREP00000016273	ENSPREP00000022246	DnaJ (Hsp40) homolog, subfamily C, member 3b.	ANK_REP_REGION domain-containing protein.	0.676
LOC103480528	dnajb11	ENSPREP00000016273	ENSPREP00000028523	DnaJ (Hsp40) homolog, subfamily C, member 3b.	DnaJ heat shock protein family (Hsp40) member B11.	0.629
LOC103480528	dnajc10	ENSPREP00000016273	ENSPREP00000031100	DnaJ (Hsp40) homolog, subfamily C, member 3b.	DnaJ (Hsp40) homolog, subfamily C, member 10.	0.604
LOC103480528	hsp90b1	ENSPREP00000016273	ENSPREP00000005847	DnaJ (Hsp40) homolog, subfamily C, member 3b.	Heat shock protein 90, beta (grp94), member 1.	0.809
LOC103480528	hspa5	ENSPREP00000016273	ENSPREP00000023630	DnaJ (Hsp40) homolog, subfamily C, member 3b.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.784
LOC103480528	hspa9	ENSPREP00000016273	ENSPREP00000001232	DnaJ (Hsp40) homolog, subfamily C, member 3b.	Heat shock protein 9; Belongs to the heat shock protein 70 family.	0.647
LOC103480528	hyou1	ENSPREP00000016273	ENSPREP00000020322	DnaJ (Hsp40) homolog, subfamily C, member 3b.	Hypoxia up-regulated 1.	0.690
LOC103480528	pdia6	ENSPREP00000016273	ENSPREP00000009774	DnaJ (Hsp40) homolog, subfamily C, member 3b.	Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family.	0.772
LOC103480528	sec63	ENSPREP00000016273	ENSPREP00000016978	DnaJ (Hsp40) homolog, subfamily C, member 3b.	SEC63 homolog, protein translocation regulator.	0.724
LOC103480528	xbp1	ENSPREP00000016273	ENSPREP00000006543	DnaJ (Hsp40) homolog, subfamily C, member 3b.	X-box binding protein 1.	0.660
dnajb11	Ankrd45	ENSPREP00000028523	ENSPREP00000022246	DnaJ heat shock protein family (Hsp40) member B11.	ANK_REP_REGION domain-containing protein.	0.681

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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