LOC103478374 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

LOC103478374

Iroquois homeobox 1a. (496 aa)

Predicted Functional Partners:

hhex

0.462

LOC103479586

0.456

pbx4

0.456

pbx3

0.456

pbx1

0.456

LOC103477587

0.456

dlx2

0.444

SRF

0.423

srf

0.423

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103477587	LOC103478374	ENSPREP00000026946	ENSPREP00000016435	Pre-B-cell leukemia homeobox 2.	Iroquois homeobox 1a.	0.456
LOC103478374	LOC103477587	ENSPREP00000016435	ENSPREP00000026946	Iroquois homeobox 1a.	Pre-B-cell leukemia homeobox 2.	0.456
LOC103478374	LOC103479586	ENSPREP00000016435	ENSPREP00000005103	Iroquois homeobox 1a.	Pre-B-cell leukemia homeobox 1a.	0.456
LOC103478374	SRF	ENSPREP00000016435	ENSPREP00000008765	Iroquois homeobox 1a.	Serum response factor.	0.423
LOC103478374	dlx2	ENSPREP00000016435	ENSPREP00000006391	Iroquois homeobox 1a.	Distal-less homeobox 2b.	0.444
LOC103478374	hhex	ENSPREP00000016435	ENSPREP00000004748	Iroquois homeobox 1a.	Homeobox domain-containing protein.	0.462
LOC103478374	pbx1	ENSPREP00000016435	ENSPREP00000020357	Iroquois homeobox 1a.	Homeobox domain-containing protein.	0.456
LOC103478374	pbx3	ENSPREP00000016435	ENSPREP00000016794	Iroquois homeobox 1a.	Homeobox domain-containing protein.	0.456
LOC103478374	pbx4	ENSPREP00000016435	ENSPREP00000007689	Iroquois homeobox 1a.	Pre-B-cell leukemia transcription factor 4.	0.456
LOC103478374	srf	ENSPREP00000016435	ENSPREP00000012906	Iroquois homeobox 1a.	Serum response factor b.	0.423
LOC103479586	LOC103478374	ENSPREP00000005103	ENSPREP00000016435	Pre-B-cell leukemia homeobox 1a.	Iroquois homeobox 1a.	0.456
SRF	LOC103478374	ENSPREP00000008765	ENSPREP00000016435	Serum response factor.	Iroquois homeobox 1a.	0.423
dlx2	LOC103478374	ENSPREP00000006391	ENSPREP00000016435	Distal-less homeobox 2b.	Iroquois homeobox 1a.	0.444
hhex	LOC103478374	ENSPREP00000004748	ENSPREP00000016435	Homeobox domain-containing protein.	Iroquois homeobox 1a.	0.462
pbx1	LOC103478374	ENSPREP00000020357	ENSPREP00000016435	Homeobox domain-containing protein.	Iroquois homeobox 1a.	0.456
pbx3	LOC103478374	ENSPREP00000016794	ENSPREP00000016435	Homeobox domain-containing protein.	Iroquois homeobox 1a.	0.456
pbx4	LOC103478374	ENSPREP00000007689	ENSPREP00000016435	Pre-B-cell leukemia transcription factor 4.	Iroquois homeobox 1a.	0.456
srf	LOC103478374	ENSPREP00000012906	ENSPREP00000016435	Serum response factor b.	Iroquois homeobox 1a.	0.423

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

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