jam3 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

jam3

Junctional adhesion molecule 3a. (306 aa)

Predicted Functional Partners:

PARD3

0.952

pard3

0.952

LOC103482508

0.949

LOC103481408

0.946

LOC103466442

0.937

LOC103462420

0.937

LOC103475799

0.927

LOC103480580

0.902

LOC103476216

0.901

jam2

0.840

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103462420	LOC103466442	ENSPREP00000033787	ENSPREP00000022800	Tight junction protein 1a; Belongs to the MAGUK family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.902
LOC103462420	LOC103475799	ENSPREP00000033787	ENSPREP00000033637	Tight junction protein 1a; Belongs to the MAGUK family.	F11 receptor, tandem duplicate 1.	0.990
LOC103462420	LOC103476216	ENSPREP00000033787	ENSPREP00000017917	Tight junction protein 1a; Belongs to the MAGUK family.	Junctional adhesion molecule 3b.	0.937
LOC103462420	LOC103480580	ENSPREP00000033787	ENSPREP00000013897	Tight junction protein 1a; Belongs to the MAGUK family.	Junctional adhesion molecule 2b.	0.902
LOC103462420	jam2	ENSPREP00000033787	ENSPREP00000014599	Tight junction protein 1a; Belongs to the MAGUK family.	Junctional adhesion molecule 2a.	0.472
LOC103462420	jam3	ENSPREP00000033787	ENSPREP00000016512	Tight junction protein 1a; Belongs to the MAGUK family.	Junctional adhesion molecule 3a.	0.937
LOC103466442	LOC103462420	ENSPREP00000022800	ENSPREP00000033787	Tight junction protein 1b; Belongs to the MAGUK family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.902
LOC103466442	LOC103475799	ENSPREP00000022800	ENSPREP00000033637	Tight junction protein 1b; Belongs to the MAGUK family.	F11 receptor, tandem duplicate 1.	0.990
LOC103466442	LOC103476216	ENSPREP00000022800	ENSPREP00000017917	Tight junction protein 1b; Belongs to the MAGUK family.	Junctional adhesion molecule 3b.	0.937
LOC103466442	LOC103480580	ENSPREP00000022800	ENSPREP00000013897	Tight junction protein 1b; Belongs to the MAGUK family.	Junctional adhesion molecule 2b.	0.902
LOC103466442	jam2	ENSPREP00000022800	ENSPREP00000014599	Tight junction protein 1b; Belongs to the MAGUK family.	Junctional adhesion molecule 2a.	0.472
LOC103466442	jam3	ENSPREP00000022800	ENSPREP00000016512	Tight junction protein 1b; Belongs to the MAGUK family.	Junctional adhesion molecule 3a.	0.937
LOC103475799	LOC103462420	ENSPREP00000033637	ENSPREP00000033787	F11 receptor, tandem duplicate 1.	Tight junction protein 1a; Belongs to the MAGUK family.	0.990
LOC103475799	LOC103466442	ENSPREP00000033637	ENSPREP00000022800	F11 receptor, tandem duplicate 1.	Tight junction protein 1b; Belongs to the MAGUK family.	0.990
LOC103475799	LOC103476216	ENSPREP00000033637	ENSPREP00000017917	F11 receptor, tandem duplicate 1.	Junctional adhesion molecule 3b.	0.927
LOC103475799	LOC103480580	ENSPREP00000033637	ENSPREP00000013897	F11 receptor, tandem duplicate 1.	Junctional adhesion molecule 2b.	0.900
LOC103475799	LOC103482508	ENSPREP00000033637	ENSPREP00000022475	F11 receptor, tandem duplicate 1.	Integrin beta.	0.938
LOC103475799	PARD3	ENSPREP00000033637	ENSPREP00000008904	F11 receptor, tandem duplicate 1.	Par-3 family cell polarity regulator.	0.955
LOC103475799	jam3	ENSPREP00000033637	ENSPREP00000016512	F11 receptor, tandem duplicate 1.	Junctional adhesion molecule 3a.	0.927
LOC103475799	pard3	ENSPREP00000033637	ENSPREP00000027405	F11 receptor, tandem duplicate 1.	Par-3 family cell polarity regulator alpha, b.	0.955

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.945

expected number of edges:

16

PPI enrichment p-value:

0.00486

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

7 of 22

1.85

3.37

4.32e-09

GO:0034660

ncRNA metabolic process

8 of 90

1.3

1.79

1.65e-07

GO:0010467

Gene expression

8 of 212

0.93

0.91

3.36e-05

GO:0019538

Protein metabolic process

8 of 217

0.92

0.9

3.72e-05

GO:0044281

Small molecule metabolic process

8 of 370

0.69

0.54

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

7 of 23

1.83

3.37

3.08e-09

GO:0000049

tRNA binding

5 of 26

1.63

2.04

8.55e-06

GO:0002161

aminoacyl-tRNA editing activity

2 of 8

1.75

0.86

0.0201

GO:0005524

ATP binding

8 of 294

0.79

0.67

0.00040

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 923

0.39

0.27

0.0350

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23606477

(2013) Genomes of the class Erysipelotrichia clarify the firmicute origin of the class Mollicutes.

4 of 11

1.91

2.31

1.07e-05

PMID:37932270

(2023) Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts.

2 of 4

2.05

1.2

0.0051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:445

Mixed, incl. PDZ domain, and Alditol phosphate metabolic process

4 of 5

2.25

2.68

5.56e-06

CL:328

Aminoacyl-tRNA synthetase

5 of 18

1.79

2.3

5.56e-06

CL:330

Aminoacyl-tRNA synthetase

4 of 11

1.91

2.08

4.03e-05

CL:72

Peptide biosynthetic process, and Coiled coil

10 of 198

1.05

1.3

8.36e-08

CL:334

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

2 of 5

1.95

0.88

0.0213

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

7 of 30

1.72

3.1

2.87e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

7 of 21

1.87

3.66

5.98e-10

KW-0648

Protein biosynthesis

7 of 46

1.53

2.42

3.76e-08

KW-0820

tRNA-binding

4 of 15

1.78

2.03

2.80e-05

KW-0862

Zinc

4 of 45

1.3

1.13

0.00089

KW-0963

Cytoplasm

8 of 214

0.92

2.13e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 5

2.13

1.5

0.0013

PF08264

Anticodon-binding domain of tRNA ligase

2 of 3

2.17

0.8

0.0327

PF01588

Putative tRNA binding domain

2 of 3

2.17

0.8

0.0327

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045864

Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

4 of 14

1.81

1.53

0.00064

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

2.05

1.33

0.0028

IPR012340

Nucleic acid-binding, OB-fold

4 of 33

1.43

1.02

0.0044

IPR018163

Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily

2 of 2

2.35

0.85

0.0275

IPR012947

Threonyl/alanyl tRNA synthetase, SAD

2 of 2

2.35

0.85

0.0275

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 2

2.35

1.09

0.0098

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