ENSPREP00000016614 protein (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSPREP00000016614

Peptidase S1 domain-containing protein. (300 aa)

Predicted Functional Partners:

LOC103478000

0.901

masp2

0.899

ENSPREP00000016678

0.885

LOC103467244

0.766

met

0.565

LOC103464537

0.565

mst1r

0.565

ENSPREP00000011401

0.536

LOC103463677

0.536

COLEC10

0.523

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COLEC10	ENSPREP00000016614	ENSPREP00000015637	ENSPREP00000016614	Collectin subfamily member 10.	Peptidase S1 domain-containing protein.	0.523
COLEC10	ENSPREP00000016678	ENSPREP00000015637	ENSPREP00000016678	Collectin subfamily member 10.	CUB domain-containing protein.	0.523
COLEC10	LOC103478000	ENSPREP00000015637	ENSPREP00000016539	Collectin subfamily member 10.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.523
ENSPREP00000011401	ENSPREP00000016614	ENSPREP00000011401	ENSPREP00000016614	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Peptidase S1 domain-containing protein.	0.536
ENSPREP00000011401	LOC103464537	ENSPREP00000011401	ENSPREP00000005623	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Macrophage stimulating 1 receptor a.	0.565
ENSPREP00000011401	LOC103478000	ENSPREP00000011401	ENSPREP00000016539	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.438
ENSPREP00000011401	met	ENSPREP00000011401	ENSPREP00000003866	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	MET proto-oncogene, receptor tyrosine kinase.	0.565
ENSPREP00000011401	mst1r	ENSPREP00000011401	ENSPREP00000031908	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Macrophage stimulating 1 receptor b.	0.565
ENSPREP00000016614	COLEC10	ENSPREP00000016614	ENSPREP00000015637	Peptidase S1 domain-containing protein.	Collectin subfamily member 10.	0.523
ENSPREP00000016614	ENSPREP00000011401	ENSPREP00000016614	ENSPREP00000011401	Peptidase S1 domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.536
ENSPREP00000016614	ENSPREP00000016678	ENSPREP00000016614	ENSPREP00000016678	Peptidase S1 domain-containing protein.	CUB domain-containing protein.	0.885
ENSPREP00000016614	LOC103463677	ENSPREP00000016614	ENSPREP00000011438	Peptidase S1 domain-containing protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.536
ENSPREP00000016614	LOC103464537	ENSPREP00000016614	ENSPREP00000005623	Peptidase S1 domain-containing protein.	Macrophage stimulating 1 receptor a.	0.565
ENSPREP00000016614	LOC103467244	ENSPREP00000016614	ENSPREP00000012821	Peptidase S1 domain-containing protein.	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	0.766
ENSPREP00000016614	LOC103478000	ENSPREP00000016614	ENSPREP00000016539	Peptidase S1 domain-containing protein.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.901
ENSPREP00000016614	masp2	ENSPREP00000016614	ENSPREP00000024031	Peptidase S1 domain-containing protein.	Mannan-binding lectin serine peptidase 2.	0.899
ENSPREP00000016614	met	ENSPREP00000016614	ENSPREP00000003866	Peptidase S1 domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.565
ENSPREP00000016614	mst1r	ENSPREP00000016614	ENSPREP00000031908	Peptidase S1 domain-containing protein.	Macrophage stimulating 1 receptor b.	0.565
ENSPREP00000016678	COLEC10	ENSPREP00000016678	ENSPREP00000015637	CUB domain-containing protein.	Collectin subfamily member 10.	0.523
ENSPREP00000016678	ENSPREP00000016614	ENSPREP00000016678	ENSPREP00000016614	CUB domain-containing protein.	Peptidase S1 domain-containing protein.	0.885

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About