ptpn6 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ptpn6

Protein tyrosine phosphatase non-receptor type 6. (573 aa)

Predicted Functional Partners:

grb2

0.942

gab1

0.858

LOC103480707

0.858

sos1

0.785

sos2

0.785

pdgfrb

0.762

gab2

0.751

ENSPREP00000004666

0.748

LOC103469131

0.748

grap2

0.729

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004666	ptpn6	ENSPREP00000004666	ENSPREP00000016776	Si:dkey-237i9.8.	Protein tyrosine phosphatase non-receptor type 6.	0.748
LOC103469131	ptpn6	ENSPREP00000023477	ENSPREP00000016776	Platelet/endothelial cell adhesion molecule 1.	Protein tyrosine phosphatase non-receptor type 6.	0.748
LOC103480707	gab1	ENSPREP00000018230	ENSPREP00000000728	PH domain-containing protein.	GRB2-associated binding protein 1.	0.900
LOC103480707	grap2	ENSPREP00000018230	ENSPREP00000018946	PH domain-containing protein.	GRB2 related adaptor protein 2a.	0.841
LOC103480707	grb2	ENSPREP00000018230	ENSPREP00000022510	PH domain-containing protein.	Growth factor receptor-bound protein 2b.	0.997
LOC103480707	ptpn6	ENSPREP00000018230	ENSPREP00000016776	PH domain-containing protein.	Protein tyrosine phosphatase non-receptor type 6.	0.858
LOC103480707	sos1	ENSPREP00000018230	ENSPREP00000008888	PH domain-containing protein.	Son of sevenless homolog 1 (Drosophila).	0.525
LOC103480707	sos2	ENSPREP00000018230	ENSPREP00000026590	PH domain-containing protein.	Son of sevenless homolog 2 (Drosophila).	0.525
gab1	LOC103480707	ENSPREP00000000728	ENSPREP00000018230	GRB2-associated binding protein 1.	PH domain-containing protein.	0.900
gab1	grap2	ENSPREP00000000728	ENSPREP00000018946	GRB2-associated binding protein 1.	GRB2 related adaptor protein 2a.	0.783
gab1	grb2	ENSPREP00000000728	ENSPREP00000022510	GRB2-associated binding protein 1.	Growth factor receptor-bound protein 2b.	0.997
gab1	ptpn6	ENSPREP00000000728	ENSPREP00000016776	GRB2-associated binding protein 1.	Protein tyrosine phosphatase non-receptor type 6.	0.858
gab1	sos1	ENSPREP00000000728	ENSPREP00000008888	GRB2-associated binding protein 1.	Son of sevenless homolog 1 (Drosophila).	0.525
gab1	sos2	ENSPREP00000000728	ENSPREP00000026590	GRB2-associated binding protein 1.	Son of sevenless homolog 2 (Drosophila).	0.525
gab2	grap2	ENSPREP00000022034	ENSPREP00000018946	GRB2-associated binding protein 2.	GRB2 related adaptor protein 2a.	0.713
gab2	grb2	ENSPREP00000022034	ENSPREP00000022510	GRB2-associated binding protein 2.	Growth factor receptor-bound protein 2b.	0.983
gab2	ptpn6	ENSPREP00000022034	ENSPREP00000016776	GRB2-associated binding protein 2.	Protein tyrosine phosphatase non-receptor type 6.	0.751
grap2	LOC103480707	ENSPREP00000018946	ENSPREP00000018230	GRB2 related adaptor protein 2a.	PH domain-containing protein.	0.841
grap2	gab1	ENSPREP00000018946	ENSPREP00000000728	GRB2 related adaptor protein 2a.	GRB2-associated binding protein 1.	0.783
grap2	gab2	ENSPREP00000018946	ENSPREP00000022034	GRB2 related adaptor protein 2a.	GRB2-associated binding protein 2.	0.713