mpv17l2 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

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mpv17l2

MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (218 aa)

Predicted Functional Partners:

mpv17l

0.911

LOC103469059

0.911

pex19

0.766

pex3

0.699

pex16

0.675

eci2

0.633

pex14

0.626

pex12

0.606

pex11a

0.584

pex11b

0.584

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103469059	eci2	ENSPREP00000019598	ENSPREP00000014783	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Enoyl-CoA delta isomerase 2.	0.568
LOC103469059	mpv17l	ENSPREP00000019598	ENSPREP00000000679	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.901
LOC103469059	mpv17l2	ENSPREP00000019598	ENSPREP00000016887	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.911
LOC103469059	pex11a	ENSPREP00000019598	ENSPREP00000009677	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 11 alpha.	0.475
LOC103469059	pex11b	ENSPREP00000019598	ENSPREP00000029865	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 11 beta.	0.475
LOC103469059	pex12	ENSPREP00000019598	ENSPREP00000009322	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.523
LOC103469059	pex16	ENSPREP00000019598	ENSPREP00000012233	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal membrane protein PEX16.	0.564
LOC103469059	pex19	ENSPREP00000019598	ENSPREP00000001567	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 19.	0.640
LOC103469059	pex3	ENSPREP00000019598	ENSPREP00000020654	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 3.	0.583
eci2	LOC103469059	ENSPREP00000014783	ENSPREP00000019598	Enoyl-CoA delta isomerase 2.	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.568
eci2	mpv17l	ENSPREP00000014783	ENSPREP00000000679	Enoyl-CoA delta isomerase 2.	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.568
eci2	mpv17l2	ENSPREP00000014783	ENSPREP00000016887	Enoyl-CoA delta isomerase 2.	MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.633
eci2	pex11a	ENSPREP00000014783	ENSPREP00000009677	Enoyl-CoA delta isomerase 2.	Peroxisomal biogenesis factor 11 alpha.	0.584
eci2	pex11b	ENSPREP00000014783	ENSPREP00000029865	Enoyl-CoA delta isomerase 2.	Peroxisomal biogenesis factor 11 beta.	0.584
eci2	pex12	ENSPREP00000014783	ENSPREP00000009322	Enoyl-CoA delta isomerase 2.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.955
eci2	pex14	ENSPREP00000014783	ENSPREP00000023963	Enoyl-CoA delta isomerase 2.	Peroxisomal biogenesis factor 14.	0.953
eci2	pex16	ENSPREP00000014783	ENSPREP00000012233	Enoyl-CoA delta isomerase 2.	Peroxisomal membrane protein PEX16.	0.483
eci2	pex19	ENSPREP00000014783	ENSPREP00000001567	Enoyl-CoA delta isomerase 2.	Peroxisomal biogenesis factor 19.	0.588
eci2	pex3	ENSPREP00000014783	ENSPREP00000020654	Enoyl-CoA delta isomerase 2.	Peroxisomal biogenesis factor 3.	0.569
mpv17l	LOC103469059	ENSPREP00000000679	ENSPREP00000019598	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.901

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

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