rest protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

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[Homology]

Score

rest

RE1-silencing transcription factor. (902 aa)

Predicted Functional Partners:

kdm1a

0.872

rcor1

0.860

rcor2

0.785

rcor3

0.785

phf21a

0.676

LOC103462700

0.655

sin3a

0.655

sin3b

0.655

arid4b

0.631

sap18

0.601

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103462700	arid4b	ENSPREP00000006807	ENSPREP00000011747	SIN3 transcription regulator family member Ab.	Translocase of outer mitochondrial membrane 20.	0.932
LOC103462700	rest	ENSPREP00000006807	ENSPREP00000016933	SIN3 transcription regulator family member Ab.	RE1-silencing transcription factor.	0.655
LOC103462700	sap18	ENSPREP00000006807	ENSPREP00000009990	SIN3 transcription regulator family member Ab.	Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins.	0.690
arid4b	LOC103462700	ENSPREP00000011747	ENSPREP00000006807	Translocase of outer mitochondrial membrane 20.	SIN3 transcription regulator family member Ab.	0.932
arid4b	kdm1a	ENSPREP00000011747	ENSPREP00000006670	Translocase of outer mitochondrial membrane 20.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.684
arid4b	phf21a	ENSPREP00000011747	ENSPREP00000030809	Translocase of outer mitochondrial membrane 20.	PHD finger protein 21Ab.	0.748
arid4b	rcor1	ENSPREP00000011747	ENSPREP00000006226	Translocase of outer mitochondrial membrane 20.	REST corepressor 1.	0.668
arid4b	rcor2	ENSPREP00000011747	ENSPREP00000001173	Translocase of outer mitochondrial membrane 20.	REST corepressor 2.	0.668
arid4b	rcor3	ENSPREP00000011747	ENSPREP00000033517	Translocase of outer mitochondrial membrane 20.	REST corepressor 3.	0.668
arid4b	rest	ENSPREP00000011747	ENSPREP00000016933	Translocase of outer mitochondrial membrane 20.	RE1-silencing transcription factor.	0.631
arid4b	sap18	ENSPREP00000011747	ENSPREP00000009990	Translocase of outer mitochondrial membrane 20.	Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins.	0.966
arid4b	sin3a	ENSPREP00000011747	ENSPREP00000018848	Translocase of outer mitochondrial membrane 20.	SIN3 transcription regulator family member Aa.	0.932
arid4b	sin3b	ENSPREP00000011747	ENSPREP00000026319	Translocase of outer mitochondrial membrane 20.	SIN3 transcription regulator family member B.	0.932
kdm1a	arid4b	ENSPREP00000006670	ENSPREP00000011747	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Translocase of outer mitochondrial membrane 20.	0.684
kdm1a	phf21a	ENSPREP00000006670	ENSPREP00000030809	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	PHD finger protein 21Ab.	0.964
kdm1a	rcor1	ENSPREP00000006670	ENSPREP00000006226	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	REST corepressor 1.	0.971
kdm1a	rcor2	ENSPREP00000006670	ENSPREP00000001173	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	REST corepressor 2.	0.953
kdm1a	rcor3	ENSPREP00000006670	ENSPREP00000033517	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	REST corepressor 3.	0.953
kdm1a	rest	ENSPREP00000006670	ENSPREP00000016933	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	RE1-silencing transcription factor.	0.872
kdm1a	sap18	ENSPREP00000006670	ENSPREP00000009990	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins.	0.702