LOC103477991 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC103477991

Uncharacterized protein. (191 aa)

Predicted Functional Partners:

was

0.970

LOC103465991

0.970

iqgap2

0.965

iqgap3

0.965

iqgap1

0.965

LOC103458433

0.963

pak2

0.963

PAK3

0.963

PAK6

0.960

pak5

0.960

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103458433	LOC103465991	ENSPREP00000016553	ENSPREP00000020180	Non-specific serine/threonine protein kinase.	WASP like actin nucleation promoting factor a.	0.417
LOC103458433	LOC103477991	ENSPREP00000016553	ENSPREP00000017385	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.963
LOC103458433	PAK3	ENSPREP00000016553	ENSPREP00000034117	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.650
LOC103458433	iqgap1	ENSPREP00000016553	ENSPREP00000025546	Non-specific serine/threonine protein kinase.	IQ motif containing GTPase activating protein 1.	0.449
LOC103458433	iqgap2	ENSPREP00000016553	ENSPREP00000005523	Non-specific serine/threonine protein kinase.	IQ motif containing GTPase activating protein 2.	0.449
LOC103458433	iqgap3	ENSPREP00000016553	ENSPREP00000023421	Non-specific serine/threonine protein kinase.	IQ motif containing GTPase activating protein 3.	0.449
LOC103458433	pak2	ENSPREP00000016553	ENSPREP00000030798	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.901
LOC103458433	was	ENSPREP00000016553	ENSPREP00000004341	Non-specific serine/threonine protein kinase.	WASP actin nucleation promoting factor a.	0.417
LOC103465991	LOC103458433	ENSPREP00000020180	ENSPREP00000016553	WASP like actin nucleation promoting factor a.	Non-specific serine/threonine protein kinase.	0.417
LOC103465991	LOC103477991	ENSPREP00000020180	ENSPREP00000017385	WASP like actin nucleation promoting factor a.	Uncharacterized protein.	0.970
LOC103465991	PAK3	ENSPREP00000020180	ENSPREP00000034117	WASP like actin nucleation promoting factor a.	Non-specific serine/threonine protein kinase.	0.410
LOC103465991	iqgap1	ENSPREP00000020180	ENSPREP00000025546	WASP like actin nucleation promoting factor a.	IQ motif containing GTPase activating protein 1.	0.403
LOC103465991	iqgap2	ENSPREP00000020180	ENSPREP00000005523	WASP like actin nucleation promoting factor a.	IQ motif containing GTPase activating protein 2.	0.403
LOC103465991	iqgap3	ENSPREP00000020180	ENSPREP00000023421	WASP like actin nucleation promoting factor a.	IQ motif containing GTPase activating protein 3.	0.403
LOC103465991	pak2	ENSPREP00000020180	ENSPREP00000030798	WASP like actin nucleation promoting factor a.	Non-specific serine/threonine protein kinase.	0.417
LOC103477991	LOC103458433	ENSPREP00000017385	ENSPREP00000016553	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.963
LOC103477991	LOC103465991	ENSPREP00000017385	ENSPREP00000020180	Uncharacterized protein.	WASP like actin nucleation promoting factor a.	0.970
LOC103477991	PAK3	ENSPREP00000017385	ENSPREP00000034117	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.963
LOC103477991	PAK6	ENSPREP00000017385	ENSPREP00000019444	Uncharacterized protein.	P21 protein (Cdc42/Rac)-activated kinase 6b.	0.960
LOC103477991	iqgap1	ENSPREP00000017385	ENSPREP00000025546	Uncharacterized protein.	IQ motif containing GTPase activating protein 1.	0.965

page 1 of 5

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.564

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

5 of 13

2.93

5.3

1.41e-10

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

4 of 7

3.11

4.74

2.06e-09

GO:0019752

Carboxylic acid metabolic process

8 of 477

1.57

2.75

2.06e-09

GO:0045454

Cell redox homeostasis

3 of 20

2.53

2.65

1.03e-05

GO:0009063

Cellular amino acid catabolic process

3 of 42

2.2

2.15

6.41e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004148

Dihydrolipoyl dehydrogenase activity

3 of 6

3.05

2.81

7.67e-06

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 8

2.92

2.8

7.67e-06

GO:0016746

Acyltransferase activity

5 of 166

1.83

2.29

7.67e-06

GO:0003863

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

2 of 2

3.35

2.04

0.00021

GO:0016491

Oxidoreductase activity

6 of 680

1.29

1.4

5.20e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

10 of 45

2.7

11.15

9.60e-24

GO:0045240

Dihydrolipoyl dehydrogenase complex

6 of 12

3.05

7.52

9.24e-15

GO:0045254

Pyruvate dehydrogenase complex

4 of 5

3.25

5.34

1.81e-10

GO:0005759

Mitochondrial matrix

6 of 76

2.25

4.87

3.83e-11

GO:0045252

Oxoglutarate dehydrogenase complex

4 of 10

2.95

4.8

1.30e-09

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23006831

(2012) Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation.

3 of 3

3.35

2.98

4.18e-06

PMID:34702846

(2021) MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes.

3 of 4

3.22

2.97

4.18e-06

PMID:30619403

(2018) Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana.

3 of 5

3.13

2.96

4.18e-06

PMID:31266864

(2019) DayNight Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolae.

3 of 8

2.92

2.77

8.61e-06

PMID:33413098

(2021) Nutrient-imbalanced conditions shift the interplay between zooplankton and gut microbiota.

3 of 9

2.87

2.75

9.18e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14150

Dihydrolipoyl dehydrogenase complex, and acetyl-CoA biosynthetic process from pyruvate

11 of 19

3.11

15.36

2.61e-30

CL:14153

Citrate cycle (TCA cycle)

8 of 12

3.17

11.04

2.13e-21

CL:14155

acetyl-CoA biosynthetic process from pyruvate, and Dihydrolipoyl dehydrogenase activity

5 of 6

3.27

6.6

8.43e-13

CL:14167

Thiamine pyrophosphate binding, and Succinyltransferase activity

2 of 5

2.95

1.66

0.0010

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gtt00020

Citrate cycle (TCA cycle)

8 of 22

2.91

10.09

3.15e-20

gtt00620

Pyruvate metabolism

7 of 42

2.57

7.41

9.44e-16

gtt00640

Propanoate metabolism

6 of 21

2.8

7.37

6.87e-15

gtt00280

Valine, leucine and isoleucine degradation

6 of 26

2.71

7.05

1.84e-14

gtt00010

Glycolysis / Gluconeogenesis

7 of 55

2.45

6.94

3.00e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389661

Glyoxylate metabolism and glycine degradation

11 of 42

2.77

13.04

1.33e-27

MAP-70268

Pyruvate metabolism

7 of 26

2.78

8.0

2.81e-16

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

8 of 53

2.53

7.88

4.20e-17

MAP-71291

Metabolism of amino acids and derivatives

11 of 248

2.0

6.55

6.19e-20

MAP-70895

Branched-chain amino acid catabolism

6 of 28

2.68

6.44

2.90e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 37

2.63

7.06

9.50e-15

GOCC:0045254

Pyruvate dehydrogenase complex

4 of 7

3.11

4.66

2.90e-09

GOCC:0045240

Dihydrolipoyl dehydrogenase complex

3 of 6

3.05

3.26

1.13e-06

GOCC:0005947

Mitochondrial alpha-ketoglutarate dehydrogenase complex

2 of 2

3.35

2.2

0.00011

GOCC:0005759

Mitochondrial matrix

3 of 56

2.08

1.91

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

3 of 4

3.22

3.46

5.20e-07

KW-0012

Acyltransferase

3 of 35

2.28

2.27

4.15e-05

KW-0560

Oxidoreductase

4 of 136

1.82

2.03

3.60e-05

KW-0786

Thiamine pyrophosphate

2 of 5

2.95

2.03

0.00021

KW-0676

Redox-active center

2 of 20

2.35

1.46

0.0019

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

5 of 5

3.35

6.4

2.19e-12

PF02817

e3 binding domain

3 of 3

3.35

3.34

9.36e-07

PF00364

Biotin-requiring enzyme

3 of 9

2.87

2.82

6.86e-06

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 14

2.68

2.59

1.59e-05

PF02780

Transketolase, C-terminal domain

2 of 7

2.8

1.51

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001078

2-oxoacid dehydrogenase acyltransferase, catalytic domain

5 of 5

3.35

6.17

5.90e-12

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

5 of 15

2.87

5.21

1.81e-10

IPR036625

E3-binding domain superfamily

3 of 3

3.35

3.19

1.69e-06

IPR004167

Peripheral subunit-binding domain

3 of 3

3.35

3.19

1.69e-06

IPR045257

Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component

3 of 4

3.22

3.17

1.77e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 8

2.75

1.39

0.0030

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About