LOC103457064 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

LOC103457064

SERPIN domain-containing protein; Belongs to the serpin family. (394 aa)

Predicted Functional Partners:

LOC103461260

0.650

LOC103481618

0.550

ENSPREP00000010844

0.538

prdx5

0.476

ENSPREP00000031431

0.475

atp6ap2

0.422

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010844	LOC103457064	ENSPREP00000010844	ENSPREP00000017782	SERPIN domain-containing protein; Belongs to the serpin family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.538
ENSPREP00000010844	atp6ap2	ENSPREP00000010844	ENSPREP00000010957	SERPIN domain-containing protein; Belongs to the serpin family.	ATPase H+ transporting accessory protein 2.	0.408
ENSPREP00000031431	LOC103457064	ENSPREP00000031431	ENSPREP00000017782	Glutamine synthetase.	SERPIN domain-containing protein; Belongs to the serpin family.	0.475
LOC103457064	ENSPREP00000010844	ENSPREP00000017782	ENSPREP00000010844	SERPIN domain-containing protein; Belongs to the serpin family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.538
LOC103457064	ENSPREP00000031431	ENSPREP00000017782	ENSPREP00000031431	SERPIN domain-containing protein; Belongs to the serpin family.	Glutamine synthetase.	0.475
LOC103457064	LOC103461260	ENSPREP00000017782	ENSPREP00000006384	SERPIN domain-containing protein; Belongs to the serpin family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.650
LOC103457064	LOC103481618	ENSPREP00000017782	ENSPREP00000013185	SERPIN domain-containing protein; Belongs to the serpin family.	Microtubule-associated protein.	0.550
LOC103457064	atp6ap2	ENSPREP00000017782	ENSPREP00000010957	SERPIN domain-containing protein; Belongs to the serpin family.	ATPase H+ transporting accessory protein 2.	0.422
LOC103457064	prdx5	ENSPREP00000017782	ENSPREP00000017624	SERPIN domain-containing protein; Belongs to the serpin family.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.476
LOC103461260	LOC103457064	ENSPREP00000006384	ENSPREP00000017782	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.650
LOC103461260	LOC103481618	ENSPREP00000006384	ENSPREP00000013185	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Microtubule-associated protein.	0.498
LOC103481618	LOC103457064	ENSPREP00000013185	ENSPREP00000017782	Microtubule-associated protein.	SERPIN domain-containing protein; Belongs to the serpin family.	0.550
LOC103481618	LOC103461260	ENSPREP00000013185	ENSPREP00000006384	Microtubule-associated protein.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.498
atp6ap2	ENSPREP00000010844	ENSPREP00000010957	ENSPREP00000010844	ATPase H+ transporting accessory protein 2.	SERPIN domain-containing protein; Belongs to the serpin family.	0.408
atp6ap2	LOC103457064	ENSPREP00000010957	ENSPREP00000017782	ATPase H+ transporting accessory protein 2.	SERPIN domain-containing protein; Belongs to the serpin family.	0.422
prdx5	LOC103457064	ENSPREP00000017624	ENSPREP00000017782	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	SERPIN domain-containing protein; Belongs to the serpin family.	0.476

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.856

expected number of edges:

11

PPI enrichment p-value:

1.8e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000413

Protein peptidyl-prolyl isomerization

5 of 29

2.46

3.83

5.95e-08

GO:0006607

NLS-bearing protein import into nucleus

4 of 16

2.62

3.3

9.58e-07

GO:0051642

Centrosome localization

4 of 34

2.29

2.8

4.84e-06

GO:0006111

Regulation of gluconeogenesis

4 of 36

2.27

2.78

4.84e-06

GO:0051028

mRNA transport

5 of 83

2.0

2.74

2.06e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061665

SUMO ligase activity

4 of 13

2.71

3.52

4.17e-07

GO:0031267

Small GTPase binding

4 of 230

1.46

0.99

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044614

Nuclear pore cytoplasmic filaments

5 of 6

3.14

6.07

1.46e-11

GO:0005642

Annulate lamellae

4 of 7

2.98

4.39

1.44e-08

GO:0106068

SUMO ligase complex

4 of 11

2.78

4.09

3.97e-08

GO:0042405

Nuclear inclusion body

4 of 11

2.78

4.09

3.97e-08

GO:0044615

Nuclear pore nuclear basket

4 of 13

2.71

4.06

3.97e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5955

Transport of Mature mRNA Derived from an Intronless Transcript

5 of 35

2.38

3.77

5.74e-08

CL:5958

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 29

2.36

3.17

1.01e-06

CL:5999

Mixed, incl. Nuclear pore central transport channel, and Nuclear pore cytoplasmic filaments

2 of 7

2.68

1.43

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

5 of 60

2.14

3.22

3.24e-07

MAP-72202

Transport of Mature Transcript to Cytoplasm

5 of 65

2.11

3.18

3.24e-07

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 40

2.22

2.75

4.93e-06

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 41

2.21

2.74

4.93e-06

MAP-159227

Transport of the SLBP independent Mature mRNA

4 of 41

2.21

2.74

4.93e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044614

Nuclear pore cytoplasmic filaments

4 of 5

3.12

4.45

1.28e-08

GOCC:0005643

Nuclear pore

5 of 54

2.19

3.5

9.09e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045255

Ran binding protein RanBP1-like

3 of 8

2.79

2.14

0.00016

IPR000156

Ran binding domain

3 of 8

2.79

2.14

0.00016

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

3 of 8

2.79

2.65

1.88e-05

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