LOC103480752 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103480752

Uncharacterized protein. (616 aa)

Predicted Functional Partners:

fau

0.863

LOC103461037

0.577

gle1

0.475

kiz

0.430

asf1b

0.427

LOC103468786

0.427

rps13

0.427

Clg10h5orf45

0.427

habp2

0.425

HGFAC

0.425

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Clg10h5orf45	LOC103480752	ENSPREP00000016757	ENSPREP00000018099	Uncharacterized protein.	Uncharacterized protein.	0.427
Clg10h5orf45	fau	ENSPREP00000016757	ENSPREP00000022382	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
HGFAC	LOC103480752	ENSPREP00000020844	ENSPREP00000018099	HGF activator.	Uncharacterized protein.	0.425
HGFAC	fau	ENSPREP00000020844	ENSPREP00000022382	HGF activator.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.455
HGFAC	habp2	ENSPREP00000020844	ENSPREP00000013460	HGF activator.	Uncharacterized protein.	0.460
LOC103461037	LOC103480752	ENSPREP00000019992	ENSPREP00000018099	RAN binding protein 2.	Uncharacterized protein.	0.577
LOC103461037	gle1	ENSPREP00000019992	ENSPREP00000005552	RAN binding protein 2.	GLE1 RNA export mediator.	0.972
LOC103468786	LOC103480752	ENSPREP00000006156	ENSPREP00000018099	Anti-silencing function 1Ba histone chaperone.	Uncharacterized protein.	0.427
LOC103480752	Clg10h5orf45	ENSPREP00000018099	ENSPREP00000016757	Uncharacterized protein.	Uncharacterized protein.	0.427
LOC103480752	HGFAC	ENSPREP00000018099	ENSPREP00000020844	Uncharacterized protein.	HGF activator.	0.425
LOC103480752	LOC103461037	ENSPREP00000018099	ENSPREP00000019992	Uncharacterized protein.	RAN binding protein 2.	0.577
LOC103480752	LOC103468786	ENSPREP00000018099	ENSPREP00000006156	Uncharacterized protein.	Anti-silencing function 1Ba histone chaperone.	0.427
LOC103480752	asf1b	ENSPREP00000018099	ENSPREP00000000446	Uncharacterized protein.	Anti-silencing function 1Ba histone chaperone.	0.427
LOC103480752	fau	ENSPREP00000018099	ENSPREP00000022382	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.863
LOC103480752	gle1	ENSPREP00000018099	ENSPREP00000005552	Uncharacterized protein.	GLE1 RNA export mediator.	0.475
LOC103480752	habp2	ENSPREP00000018099	ENSPREP00000013460	Uncharacterized protein.	Uncharacterized protein.	0.425
LOC103480752	kiz	ENSPREP00000018099	ENSPREP00000001326	Uncharacterized protein.	Kizuna centrosomal protein.	0.430
LOC103480752	rps13	ENSPREP00000018099	ENSPREP00000006834	Uncharacterized protein.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.427
asf1b	LOC103480752	ENSPREP00000000446	ENSPREP00000018099	Anti-silencing function 1Ba histone chaperone.	Uncharacterized protein.	0.427
fau	Clg10h5orf45	ENSPREP00000022382	ENSPREP00000016757	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Uncharacterized protein.	0.999

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033353

S-adenosylmethionine cycle

3 of 6

3.32

4.18

3.97e-06

GO:0006730

One-carbon metabolic process

3 of 34

2.56

2.9

0.00012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

3.62

5.1

2.79e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30809531

(2019) ITRAQ-Based Quantitative Proteomics Reveals the Proteome Profiles of Primary Duck Embryo Fibroblast Cells Infected with Duck Tembusu Virus.

3 of 15

2.92

3.43

3.13e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7158

Sulfur amino acid biosynthetic process, and Adenosylhomocysteinase-like

3 of 12

3.02

3.86

8.79e-06

CL:7161

Cysteine biosynthetic process, and Adenosylhomocysteinase-like

2 of 5

3.22

2.46

0.00067

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00270

Cysteine and methionine metabolism

3 of 35

2.55

3.73

7.31e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

3.62

4.82

6.35e-07

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

3.62

4.82

6.35e-07

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

4.82

6.35e-07

IPR000043

Adenosylhomocysteinase-like

3 of 3

3.62

4.82

6.35e-07

IPR036291

NAD(P)-binding domain superfamily

3 of 142

1.94

1.7

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

5.53

7.62e-08

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