LOC103458418 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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LOC103458418

Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (384 aa)

Predicted Functional Partners:

LOC103464532

0.662

LOC103468349

0.662

LOC103468882

0.660

ENSPREP00000031543

0.631

LOC103465401

0.626

LOC103475296

0.598

bmp15

0.565

pold1

0.553

noc4l

0.549

wdr46

0.549

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000031543	LOC103458418	ENSPREP00000031543	ENSPREP00000018181	Uncharacterized protein.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.631
LOC103458418	ENSPREP00000031543	ENSPREP00000018181	ENSPREP00000031543	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.631
LOC103458418	LOC103464532	ENSPREP00000018181	ENSPREP00000000699	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E receptor 1a (subtype EP1).	0.662
LOC103458418	LOC103465401	ENSPREP00000018181	ENSPREP00000025838	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	GLUCAGON domain-containing protein.	0.626
LOC103458418	LOC103468349	ENSPREP00000018181	ENSPREP00000020224	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E receptor 1b (subtype EP1); Belongs to the G-protein coupled receptor 1 family.	0.662
LOC103458418	LOC103468882	ENSPREP00000018181	ENSPREP00000007027	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E receptor 1c (subtype EP1).	0.660
LOC103458418	LOC103475296	ENSPREP00000018181	ENSPREP00000004434	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Somatostatin.	0.598
LOC103458418	bmp15	ENSPREP00000018181	ENSPREP00000015246	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Bone morphogenetic protein 15.	0.565
LOC103458418	noc4l	ENSPREP00000018181	ENSPREP00000010537	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Nucleolar complex associated 4 homolog.	0.549
LOC103458418	pold1	ENSPREP00000018181	ENSPREP00000020414	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	DNA polymerase.	0.553
LOC103458418	wdr46	ENSPREP00000018181	ENSPREP00000024683	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	WD repeat domain 46.	0.549
LOC103464532	LOC103458418	ENSPREP00000000699	ENSPREP00000018181	Prostaglandin E receptor 1a (subtype EP1).	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.662
LOC103465401	LOC103458418	ENSPREP00000025838	ENSPREP00000018181	GLUCAGON domain-containing protein.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.626
LOC103465401	LOC103475296	ENSPREP00000025838	ENSPREP00000004434	GLUCAGON domain-containing protein.	Somatostatin.	0.601
LOC103468349	LOC103458418	ENSPREP00000020224	ENSPREP00000018181	Prostaglandin E receptor 1b (subtype EP1); Belongs to the G-protein coupled receptor 1 family.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.662
LOC103468882	LOC103458418	ENSPREP00000007027	ENSPREP00000018181	Prostaglandin E receptor 1c (subtype EP1).	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.660
LOC103475296	LOC103458418	ENSPREP00000004434	ENSPREP00000018181	Somatostatin.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.598
LOC103475296	LOC103465401	ENSPREP00000004434	ENSPREP00000025838	Somatostatin.	GLUCAGON domain-containing protein.	0.601
bmp15	LOC103458418	ENSPREP00000015246	ENSPREP00000018181	Bone morphogenetic protein 15.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.565
noc4l	LOC103458418	ENSPREP00000010537	ENSPREP00000018181	Nucleolar complex associated 4 homolog.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.549

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.783

expected number of edges:

12

PPI enrichment p-value:

0.00012

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007018

Microtubule-based movement

6 of 308

1.61

1.88

2.26e-05

GO:0046586

Regulation of calcium-dependent cell-cell adhesion

2 of 2

3.32

1.5

0.0020

GO:0007406

Negative regulation of neuroblast proliferation

2 of 3

3.14

1.42

0.0028

GO:0000070

Mitotic sister chromatid segregation

3 of 88

1.85

1.05

0.0089

GO:0070229

Negative regulation of lymphocyte apoptotic process

2 of 11

2.58

1.05

0.0121

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

3 of 21

2.47

1.8

0.00045

GO:0019894

Kinesin binding

3 of 40

2.19

1.6

0.00090

GO:0120170

Intraciliary transport particle B binding

2 of 4

3.02

1.48

0.0021

GO:0008017

Microtubule binding

4 of 271

1.49

1.09

0.0034

GO:0008092

Cytoskeletal protein binding

7 of 1110

1.12

1.02

0.00045

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005871

Kinesin complex

4 of 63

2.12

2.42

1.38e-05

GO:0016939

Kinesin II complex

2 of 2

3.32

2.04

0.00021

GO:0005828

Kinetochore microtubule

2 of 4

3.02

1.9

0.00036

GO:0097730

Non-motile cilium

4 of 123

1.83

1.84

0.00012

GO:0005876

Spindle microtubule

3 of 49

2.1

1.84

0.00025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17888

Intraciliary transport particle, and Kinesin II complex

4 of 27

2.49

2.82

4.52e-06

CL:8090

Mixed, incl. Mitotic spindle midzone, and Spindle elongation

3 of 13

2.68

2.51

2.31e-05

CL:17865

Mixed, incl. Transport along microtubule, and Kinesins

5 of 175

1.77

2.18

1.06e-05

CL:17932

Kinesin II complex, and Microtubule anchoring at centrosome

2 of 5

2.92

1.61

0.0012

CL:17896

Intraciliary transport particle B

2 of 5

2.92

1.61

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

6 of 98

2.1

3.79

5.77e-09

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

6 of 161

1.89

3.11

5.17e-08

MAP-8856688

Golgi-to-ER retrograde transport

6 of 191

1.81

2.9

9.36e-08

MAP-2132295

MHC class II antigen presentation

6 of 213

1.77

2.77

1.33e-07

MAP-983231

Factors involved in megakaryocyte development and platelet production

6 of 217

1.76

2.76

1.33e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016939

Kinesin II complex

2 of 3

3.14

1.66

0.0010

GOCC:0005871

Kinesin complex

3 of 43

2.16

1.58

0.00095

GOCC:0015630

Microtubule cytoskeleton

6 of 556

1.35

1.38

0.00014

GOCC:0051233

Spindle midzone

2 of 12

2.54

1.25

0.0052

GOCC:0005876

Spindle microtubule

2 of 17

2.39

1.17

0.0069

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0505

Motor protein

4 of 118

1.85

1.91

8.26e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01088

Ubiquitin carboxyl-terminal hydrolase, family 1

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001752

Kinesin motor domain

4 of 54

2.19

2.09

8.61e-05

IPR036961

Kinesin motor domain superfamily

4 of 109

1.88

1.57

0.00064

IPR041507

Peptidase C12, C-terminal domain

2 of 2

3.32

1.46

0.0024

IPR008658

Kinesin-associated protein 3

2 of 2

3.32

1.46

0.0024

IPR027640

Kinesin-like protein

3 of 40

2.19

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

4 of 51

2.21

2.59

7.58e-06

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