LOC103469030 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC103469030

Microtubule-associated protein. (293 aa)

Predicted Functional Partners:

mapk1

0.910

LOC103469111

0.910

LOC103481618

0.901

cdk5

0.639

stub1

0.541

LOC103473856

0.523

LOC103461041

0.474

CASP3

0.474

LOC103473137

0.474

casp7

0.474

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	LOC103461041	ENSPREP00000001533	ENSPREP00000000103	Caspase 3; Belongs to the peptidase C14A family.	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	0.902
CASP3	LOC103469030	ENSPREP00000001533	ENSPREP00000018358	Caspase 3; Belongs to the peptidase C14A family.	Microtubule-associated protein.	0.474
CASP3	LOC103481618	ENSPREP00000001533	ENSPREP00000013185	Caspase 3; Belongs to the peptidase C14A family.	Microtubule-associated protein.	0.474
LOC103461041	CASP3	ENSPREP00000000103	ENSPREP00000001533	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Caspase 3; Belongs to the peptidase C14A family.	0.902
LOC103461041	LOC103469030	ENSPREP00000000103	ENSPREP00000018358	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Microtubule-associated protein.	0.474
LOC103461041	LOC103481618	ENSPREP00000000103	ENSPREP00000013185	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	Microtubule-associated protein.	0.474
LOC103469030	CASP3	ENSPREP00000018358	ENSPREP00000001533	Microtubule-associated protein.	Caspase 3; Belongs to the peptidase C14A family.	0.474
LOC103469030	LOC103461041	ENSPREP00000018358	ENSPREP00000000103	Microtubule-associated protein.	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	0.474
LOC103469030	LOC103469111	ENSPREP00000018358	ENSPREP00000022587	Microtubule-associated protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.910
LOC103469030	LOC103473137	ENSPREP00000018358	ENSPREP00000018681	Microtubule-associated protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.474
LOC103469030	LOC103473856	ENSPREP00000018358	ENSPREP00000025042	Microtubule-associated protein.	Uncharacterized protein; Belongs to the synuclein family.	0.523
LOC103469030	LOC103481618	ENSPREP00000018358	ENSPREP00000013185	Microtubule-associated protein.	Microtubule-associated protein.	0.901
LOC103469030	casp7	ENSPREP00000018358	ENSPREP00000033366	Microtubule-associated protein.	Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.474
LOC103469030	cdk5	ENSPREP00000018358	ENSPREP00000011776	Microtubule-associated protein.	Cyclin-dependent kinase 5.	0.639
LOC103469030	mapk1	ENSPREP00000018358	ENSPREP00000019735	Microtubule-associated protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.910
LOC103469030	stub1	ENSPREP00000018358	ENSPREP00000027637	Microtubule-associated protein.	STIP1 homology and U-Box containing protein 1.	0.541
LOC103469111	LOC103469030	ENSPREP00000022587	ENSPREP00000018358	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Microtubule-associated protein.	0.910
LOC103469111	LOC103481618	ENSPREP00000022587	ENSPREP00000013185	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Microtubule-associated protein.	0.910
LOC103469111	mapk1	ENSPREP00000022587	ENSPREP00000019735	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.900
LOC103473137	LOC103469030	ENSPREP00000018681	ENSPREP00000018358	Uncharacterized protein; Belongs to the peptidase C14A family.	Microtubule-associated protein.	0.474

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.856

expected number of edges:

11

PPI enrichment p-value:

1.8e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000413

Protein peptidyl-prolyl isomerization

5 of 29

2.46

3.83

5.95e-08

GO:0006607

NLS-bearing protein import into nucleus

4 of 16

2.62

3.3

9.58e-07

GO:0051642

Centrosome localization

4 of 34

2.29

2.8

4.84e-06

GO:0006111

Regulation of gluconeogenesis

4 of 36

2.27

2.78

4.84e-06

GO:0051028

mRNA transport

5 of 83

2.0

2.74

2.06e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061665

SUMO ligase activity

4 of 13

2.71

3.52

4.17e-07

GO:0031267

Small GTPase binding

4 of 230

1.46

0.99

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044614

Nuclear pore cytoplasmic filaments

5 of 6

3.14

6.07

1.46e-11

GO:0005642

Annulate lamellae

4 of 7

2.98

4.39

1.44e-08

GO:0106068

SUMO ligase complex

4 of 11

2.78

4.09

3.97e-08

GO:0042405

Nuclear inclusion body

4 of 11

2.78

4.09

3.97e-08

GO:0044615

Nuclear pore nuclear basket

4 of 13

2.71

4.06

3.97e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5955

Transport of Mature mRNA Derived from an Intronless Transcript

5 of 35

2.38

3.77

5.74e-08

CL:5958

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 29

2.36

3.17

1.01e-06

CL:5999

Mixed, incl. Nuclear pore central transport channel, and Nuclear pore cytoplasmic filaments

2 of 7

2.68

1.43

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

5 of 60

2.14

3.22

3.24e-07

MAP-72202

Transport of Mature Transcript to Cytoplasm

5 of 65

2.11

3.18

3.24e-07

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 40

2.22

2.75

4.93e-06

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 41

2.21

2.74

4.93e-06

MAP-159227

Transport of the SLBP independent Mature mRNA

4 of 41

2.21

2.74

4.93e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044614

Nuclear pore cytoplasmic filaments

4 of 5

3.12

4.45

1.28e-08

GOCC:0005643

Nuclear pore

5 of 54

2.19

3.5

9.09e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045255

Ran binding protein RanBP1-like

3 of 8

2.79

2.14

0.00016

IPR000156

Ran binding domain

3 of 8

2.79

2.14

0.00016

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

3 of 8

2.79

2.65

1.88e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About