LOC103474665 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC103474665

IF rod domain-containing protein; Belongs to the intermediate filament family. (478 aa)

Predicted Functional Partners:

Unc79

0.782

LOC103461037

0.540

rbbp5

0.465

ash2l

0.461

LOC103475867

0.454

kdm6b

0.454

tep1

0.450

LOC103475798

0.449

kdm6a

0.449

LOC103464941

0.437

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103461037	LOC103474665	ENSPREP00000019992	ENSPREP00000018708	RAN binding protein 2.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.540
LOC103461037	LOC103475798	ENSPREP00000019992	ENSPREP00000014271	RAN binding protein 2.	Lysine (K)-specific demethylase 6A, like.	0.742
LOC103461037	LOC103475867	ENSPREP00000019992	ENSPREP00000002425	RAN binding protein 2.	Lysine (K)-specific demethylase 6B, b.	0.739
LOC103461037	kdm6a	ENSPREP00000019992	ENSPREP00000030520	RAN binding protein 2.	Lysine (K)-specific demethylase 6A.	0.742
LOC103461037	kdm6b	ENSPREP00000019992	ENSPREP00000021959	RAN binding protein 2.	Lysine (K)-specific demethylase 6B, a.	0.739
LOC103461037	tep1	ENSPREP00000019992	ENSPREP00000002368	RAN binding protein 2.	Uncharacterized protein.	0.958
LOC103464941	LOC103474665	ENSPREP00000002250	ENSPREP00000018708	Keratin 4; Belongs to the intermediate filament family.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.437
LOC103474665	LOC103461037	ENSPREP00000018708	ENSPREP00000019992	IF rod domain-containing protein; Belongs to the intermediate filament family.	RAN binding protein 2.	0.540
LOC103474665	LOC103464941	ENSPREP00000018708	ENSPREP00000002250	IF rod domain-containing protein; Belongs to the intermediate filament family.	Keratin 4; Belongs to the intermediate filament family.	0.437
LOC103474665	LOC103475798	ENSPREP00000018708	ENSPREP00000014271	IF rod domain-containing protein; Belongs to the intermediate filament family.	Lysine (K)-specific demethylase 6A, like.	0.449
LOC103474665	LOC103475867	ENSPREP00000018708	ENSPREP00000002425	IF rod domain-containing protein; Belongs to the intermediate filament family.	Lysine (K)-specific demethylase 6B, b.	0.454
LOC103474665	Unc79	ENSPREP00000018708	ENSPREP00000021607	IF rod domain-containing protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.782
LOC103474665	ash2l	ENSPREP00000018708	ENSPREP00000022292	IF rod domain-containing protein; Belongs to the intermediate filament family.	Ash2 like, histone lysine methyltransferase complex subunit.	0.461
LOC103474665	kdm6a	ENSPREP00000018708	ENSPREP00000030520	IF rod domain-containing protein; Belongs to the intermediate filament family.	Lysine (K)-specific demethylase 6A.	0.449
LOC103474665	kdm6b	ENSPREP00000018708	ENSPREP00000021959	IF rod domain-containing protein; Belongs to the intermediate filament family.	Lysine (K)-specific demethylase 6B, a.	0.454
LOC103474665	rbbp5	ENSPREP00000018708	ENSPREP00000014432	IF rod domain-containing protein; Belongs to the intermediate filament family.	Retinoblastoma binding protein 5.	0.465
LOC103474665	tep1	ENSPREP00000018708	ENSPREP00000002368	IF rod domain-containing protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.450
LOC103475798	LOC103461037	ENSPREP00000014271	ENSPREP00000019992	Lysine (K)-specific demethylase 6A, like.	RAN binding protein 2.	0.742
LOC103475798	LOC103474665	ENSPREP00000014271	ENSPREP00000018708	Lysine (K)-specific demethylase 6A, like.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.449
LOC103475798	ash2l	ENSPREP00000014271	ENSPREP00000022292	Lysine (K)-specific demethylase 6A, like.	Ash2 like, histone lysine methyltransferase complex subunit.	0.967

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.876

expected number of edges:

12

PPI enrichment p-value:

0.000499

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010608

Post-transcriptional regulation of gene expression

7 of 445

1.51

1.99

2.82e-06

GO:0006378

mRNA polyadenylation

3 of 21

2.47

1.92

0.00027

GO:0006417

Regulation of translation

6 of 377

1.52

1.72

3.71e-05

GO:0043489

RNA stabilization

3 of 44

2.15

1.59

0.00090

GO:0017148

Negative regulation of translation

4 of 139

1.78

1.55

0.00054

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1169

1.09

0.96

0.00069

GO:0004652

Polynucleotide adenylyltransferase activity

2 of 15

2.44

0.85

0.0281

GO:1901363

Heterocyclic compound binding

10 of 6300

0.52

0.34

0.0281

GO:0097159

Organic cyclic compound binding

10 of 6378

0.51

0.34

0.0281

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

3 of 15

2.62

2.3

5.53e-05

PMID:34263725

(2021) A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma.

2 of 21

2.3

0.9

0.0218

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2940

Mixed, incl. Deadenylation-dependent mRNA decay, and Anti-proliferative protein

5 of 90

2.06

2.7

2.52e-06

CL:11094

mRNA cleavage and polyadenylation specificity factor complex

2 of 7

2.77

0.95

0.0189

CL:3058

mRNA decay by 5 to 3 exoribonuclease, and Scd6-like Sm domain

2 of 15

2.44

0.79

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04914

Progesterone-mediated oocyte maturation

3 of 88

1.85

1.38

0.0016

pret04114

Oocyte meiosis

3 of 111

1.75

1.34

0.0016

pret03018

RNA degradation

2 of 69

1.78

0.8

0.0284

pret03015

mRNA surveillance pathway

2 of 76

1.74

0.79

0.0284

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8953854

Metabolism of RNA

7 of 895

1.21

1.26

6.94e-05

MAP-429914

Deadenylation-dependent mRNA decay

3 of 74

1.93

1.18

0.0049

MAP-6804114

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

2 of 13

2.5

1.05

0.0122

MAP-77595

Processing of Intronless Pre-mRNAs

2 of 21

2.3

0.9

0.0220

MAP-75067

Processing of Capped Intronless Pre-mRNA

2 of 24

2.24

0.89

0.0226

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