mpp7 protein (Poecilia reticulata) - STRING interaction network

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Predicted Interactions

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mpp7

Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family. (576 aa)

Predicted Functional Partners:

RIMS2

0.550

polr2f

0.531

LOC103472577

0.521

lin7b

0.519

lin7a

0.519

lin7c

0.519

aprt

0.493

LOC103474147

0.493

gart

0.482

tyms

0.469

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103472577	lin7a	ENSPREP00000023069	ENSPREP00000033127	Uncharacterized protein.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.556
LOC103472577	lin7b	ENSPREP00000023069	ENSPREP00000007929	Uncharacterized protein.	L27 domain-containing protein.	0.556
LOC103472577	lin7c	ENSPREP00000023069	ENSPREP00000033453	Uncharacterized protein.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.556
LOC103472577	mpp7	ENSPREP00000023069	ENSPREP00000018862	Uncharacterized protein.	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family.	0.521
LOC103474147	gart	ENSPREP00000013162	ENSPREP00000009460	Zgc:174895.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.882
LOC103474147	mpp7	ENSPREP00000013162	ENSPREP00000018862	Zgc:174895.	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family.	0.493
LOC103474147	tyms	ENSPREP00000013162	ENSPREP00000011292	Zgc:174895.	Thymidylate synthetase.	0.553
RIMS2	lin7a	ENSPREP00000023895	ENSPREP00000033127	Regulating synaptic membrane exocytosis 2.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.556
RIMS2	lin7b	ENSPREP00000023895	ENSPREP00000007929	Regulating synaptic membrane exocytosis 2.	L27 domain-containing protein.	0.556
RIMS2	lin7c	ENSPREP00000023895	ENSPREP00000033453	Regulating synaptic membrane exocytosis 2.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.556
RIMS2	mpp7	ENSPREP00000023895	ENSPREP00000018862	Regulating synaptic membrane exocytosis 2.	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family.	0.550
aprt	gart	ENSPREP00000011471	ENSPREP00000009460	Adenine phosphoribosyltransferase.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.882
aprt	mpp7	ENSPREP00000011471	ENSPREP00000018862	Adenine phosphoribosyltransferase.	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family.	0.493
aprt	tyms	ENSPREP00000011471	ENSPREP00000011292	Adenine phosphoribosyltransferase.	Thymidylate synthetase.	0.553
gart	LOC103474147	ENSPREP00000009460	ENSPREP00000013162	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Zgc:174895.	0.882
gart	aprt	ENSPREP00000009460	ENSPREP00000011471	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Adenine phosphoribosyltransferase.	0.882
gart	mpp7	ENSPREP00000009460	ENSPREP00000018862	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family.	0.482
gart	tyms	ENSPREP00000009460	ENSPREP00000011292	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	Thymidylate synthetase.	0.712
lin7a	LOC103472577	ENSPREP00000033127	ENSPREP00000023069	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	Uncharacterized protein.	0.556
lin7a	RIMS2	ENSPREP00000033127	ENSPREP00000023895	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	Regulating synaptic membrane exocytosis 2.	0.556

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

9 of 175

2.03

5.27

5.11e-14

GO:0046486

Glycerolipid metabolic process

10 of 342

1.78

4.32

5.11e-14

GO:0006629

Lipid metabolic process

11 of 1175

1.29

2.15

1.13e-11

GO:0045017

Glycerolipid biosynthetic process

5 of 205

1.7

2.0

2.23e-05

GO:0043647

Inositol phosphate metabolic process

3 of 34

2.26

1.8

0.00037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004435

Phosphatidylinositol phospholipase C activity

4 of 24

2.54

3.22

7.90e-07

GO:0042578

Phosphoric ester hydrolase activity

8 of 473

1.55

2.52

1.51e-08

GO:0046030

Inositol trisphosphate phosphatase activity

2 of 17

2.39

1.12

0.0087

GO:0016791

Phosphatase activity

4 of 351

1.37

0.99

0.0046

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 45

1.97

0.71

0.0463

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27029

Inositol phosphate metabolism, and Inositol hexakisphosphate 5-kinase activity

9 of 84

2.35

7.32

5.58e-17

CL:27030

Inositol phosphate metabolism

8 of 67

2.39

6.88

1.86e-15

CL:27032

Inositol phosphate metabolism

7 of 45

2.51

6.48

6.76e-14

CL:27033

Inositol phosphate metabolism

6 of 39

2.5

5.46

1.34e-11

CL:27060

Mixed, incl. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain, and 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain

4 of 10

2.92

4.19

1.81e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret00562

Inositol phosphate metabolism

11 of 82

2.45

10.56

4.53e-25

pret04070

Phosphatidylinositol signaling system

11 of 88

2.41

10.39

4.68e-25

pret01100

Metabolic pathways

11 of 1488

1.19

1.85

5.14e-12

pret04020

Calcium signaling pathway

4 of 250

1.52

0.00019

pret04370

VEGF signaling pathway

2 of 64

1.81

0.94

0.0147

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

8 of 73

2.36

6.63

4.73e-15

MAP-1855204

Synthesis of IP3 and IP4 in the cytosol

5 of 45

2.36

3.92

1.55e-08

MAP-1660517

Synthesis of PIPs at the late endosome membrane

2 of 7

2.77

1.38

0.0031

MAP-202403

TCR signaling

3 of 80

1.89

1.27

0.0031

MAP-1660516

Synthesis of PIPs at the early endosome membrane

2 of 15

2.44

1.18

0.0068

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

5 of 102

2.01

3.0

3.08e-07

KW-0442

Lipid degradation

3 of 45

2.14

1.86

0.00024

KW-0378

Hydrolase

5 of 768

1.13

0.92

0.0019

KW-0807

Transducer

4 of 562

1.17

0.79

0.0089

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001711

Phospholipase C, phosphatidylinositol-specific, Y domain

4 of 23

2.56

2.9

3.59e-06

IPR001192

Phosphoinositide phospholipase C family

4 of 23

2.56

2.9

3.59e-06

IPR000909

Phosphatidylinositol-specific phospholipase C, X domain

4 of 29

2.46

2.86

3.59e-06

IPR017946

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

4 of 40

2.32

2.66

6.91e-06

IPR035892

C2 domain superfamily

5 of 228

1.66

1.79

6.56e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00149

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00148

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 185

1.65

1.53

0.00037

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