LOC103464718 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103464718

Uncharacterized protein. (1469 aa)

Predicted Functional Partners:

wdr18

0.577

tex10

0.548

pes1

0.519

LOC103458713

0.473

LOC103465350

0.473

slc7a9

0.440

LOC103461533

0.408

LOC103481623

0.403

calm2

0.403

calm1

0.403

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103458713	LOC103464718	ENSPREP00000008040	ENSPREP00000018894	Uncharacterized protein.	Uncharacterized protein.	0.473
LOC103458713	LOC103465350	ENSPREP00000008040	ENSPREP00000022741	Uncharacterized protein.	Si:dkey-28n18.9.	0.485
LOC103461533	LOC103464718	ENSPREP00000018183	ENSPREP00000018894	Myosin, light chain 1, alkali; skeletal, fast.	Uncharacterized protein.	0.408
LOC103464718	LOC103458713	ENSPREP00000018894	ENSPREP00000008040	Uncharacterized protein.	Uncharacterized protein.	0.473
LOC103464718	LOC103461533	ENSPREP00000018894	ENSPREP00000018183	Uncharacterized protein.	Myosin, light chain 1, alkali; skeletal, fast.	0.408
LOC103464718	LOC103465350	ENSPREP00000018894	ENSPREP00000022741	Uncharacterized protein.	Si:dkey-28n18.9.	0.473
LOC103464718	LOC103481623	ENSPREP00000018894	ENSPREP00000013368	Uncharacterized protein.	Zgc:112285; Belongs to the peptidase S1 family.	0.403
LOC103464718	calm1	ENSPREP00000018894	ENSPREP00000027421	Uncharacterized protein.	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.403
LOC103464718	calm2	ENSPREP00000018894	ENSPREP00000015904	Uncharacterized protein.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.403
LOC103464718	pes1	ENSPREP00000018894	ENSPREP00000033339	Uncharacterized protein.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.519
LOC103464718	slc7a9	ENSPREP00000018894	ENSPREP00000018432	Uncharacterized protein.	Solute carrier family 7 member 9.	0.440
LOC103464718	tex10	ENSPREP00000018894	ENSPREP00000027544	Uncharacterized protein.	Testis expressed 10.	0.548
LOC103464718	wdr18	ENSPREP00000018894	ENSPREP00000007976	Uncharacterized protein.	WD repeat domain 18.	0.577
LOC103465350	LOC103458713	ENSPREP00000022741	ENSPREP00000008040	Si:dkey-28n18.9.	Uncharacterized protein.	0.485
LOC103465350	LOC103464718	ENSPREP00000022741	ENSPREP00000018894	Si:dkey-28n18.9.	Uncharacterized protein.	0.473
LOC103465350	slc7a9	ENSPREP00000022741	ENSPREP00000018432	Si:dkey-28n18.9.	Solute carrier family 7 member 9.	0.483
LOC103481623	LOC103464718	ENSPREP00000013368	ENSPREP00000018894	Zgc:112285; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.403
calm1	LOC103464718	ENSPREP00000027421	ENSPREP00000018894	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Uncharacterized protein.	0.403
calm2	LOC103464718	ENSPREP00000015904	ENSPREP00000018894	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	Uncharacterized protein.	0.403
pes1	LOC103464718	ENSPREP00000033339	ENSPREP00000018894	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Uncharacterized protein.	0.519

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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