LOC103465265 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

LOC103465265

Uncharacterized protein. (661 aa)

Predicted Functional Partners:

ENSPREP00000033113

0.864

ENSPREP00000023655

0.851

LOC103458452

0.634

LOC103463549

0.634

LOC103470235

0.634

LOC103470237

0.634

LOC103463548

0.627

CDC42

0.556

LOC103465423

0.556

LOC103473462

0.500

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSPREP00000023655	ENSPREP00000005959	ENSPREP00000023655	Cell division cycle 42.	Protein kinase domain-containing protein.	0.599
CDC42	LOC103465265	ENSPREP00000005959	ENSPREP00000019032	Cell division cycle 42.	Uncharacterized protein.	0.556
ENSPREP00000023655	CDC42	ENSPREP00000023655	ENSPREP00000005959	Protein kinase domain-containing protein.	Cell division cycle 42.	0.599
ENSPREP00000023655	ENSPREP00000033113	ENSPREP00000023655	ENSPREP00000033113	Protein kinase domain-containing protein.	Uncharacterized protein.	0.886
ENSPREP00000023655	LOC103458452	ENSPREP00000023655	ENSPREP00000015705	Protein kinase domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	0.509
ENSPREP00000023655	LOC103463548	ENSPREP00000023655	ENSPREP00000017815	Protein kinase domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.509
ENSPREP00000023655	LOC103463549	ENSPREP00000023655	ENSPREP00000017763	Protein kinase domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).	0.509
ENSPREP00000023655	LOC103465265	ENSPREP00000023655	ENSPREP00000019032	Protein kinase domain-containing protein.	Uncharacterized protein.	0.851
ENSPREP00000023655	LOC103465423	ENSPREP00000023655	ENSPREP00000026666	Protein kinase domain-containing protein.	Cell division cycle 42.	0.599
ENSPREP00000023655	LOC103470235	ENSPREP00000023655	ENSPREP00000029602	Protein kinase domain-containing protein.	Uncharacterized protein.	0.509
ENSPREP00000023655	LOC103470237	ENSPREP00000023655	ENSPREP00000029648	Protein kinase domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha 14a.	0.509
ENSPREP00000023655	LOC103473462	ENSPREP00000023655	ENSPREP00000003879	Protein kinase domain-containing protein.	Uncharacterized protein.	0.509
ENSPREP00000033113	ENSPREP00000023655	ENSPREP00000033113	ENSPREP00000023655	Uncharacterized protein.	Protein kinase domain-containing protein.	0.886
ENSPREP00000033113	LOC103465265	ENSPREP00000033113	ENSPREP00000019032	Uncharacterized protein.	Uncharacterized protein.	0.864
LOC103458452	ENSPREP00000023655	ENSPREP00000015705	ENSPREP00000023655	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	Protein kinase domain-containing protein.	0.509
LOC103458452	LOC103463548	ENSPREP00000015705	ENSPREP00000017815	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.471
LOC103458452	LOC103465265	ENSPREP00000015705	ENSPREP00000019032	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	Uncharacterized protein.	0.634
LOC103463548	ENSPREP00000023655	ENSPREP00000017815	ENSPREP00000023655	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Protein kinase domain-containing protein.	0.509
LOC103463548	LOC103458452	ENSPREP00000017815	ENSPREP00000015705	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).	0.471
LOC103463548	LOC103463549	ENSPREP00000017815	ENSPREP00000017763	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).	0.470

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.905

expected number of edges:

17

PPI enrichment p-value:

0.0865

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032224

Positive regulation of synaptic transmission, cholinergic

3 of 5

3.1

2.82

7.57e-06

GO:0045995

Regulation of embryonic development

4 of 61

2.13

2.33

2.24e-05

GO:0000904

Cell morphogenesis involved in differentiation

7 of 515

1.45

1.89

2.56e-06

GO:0009887

Animal organ morphogenesis

8 of 749

1.35

1.74

1.71e-06

GO:0007411

Axon guidance

5 of 249

1.62

1.74

7.22e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005201

Extracellular matrix structural constituent

6 of 134

1.97

3.22

5.71e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005604

Basement membrane

8 of 77

2.33

6.55

5.35e-15

GO:0031012

Extracellular matrix

9 of 489

1.58

3.08

3.42e-11

GO:0043083

Synaptic cleft

3 of 9

2.84

2.95

3.81e-06

GO:0031594

Neuromuscular junction

3 of 44

2.15

1.86

0.00024

GO:0042383

Sarcolemma

3 of 77

1.91

1.49

0.0010

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36142434

(2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii).

3 of 13

2.68

2.39

3.80e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21899

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

8 of 14

3.07

10.0

1.42e-19

CL:21782

ECM-receptor interaction, and Laminin interactions

9 of 77

2.39

7.74

8.90e-18

CL:21901

MET activates PTK2 signaling, and Regulation of synaptic transmission, cholinergic

4 of 7

3.07

4.56

4.34e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04512

ECM-receptor interaction

5 of 84

2.09

3.38

6.00e-08

pret04510

Focal adhesion

5 of 212

1.69

2.26

2.69e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3000157

Laminin interactions

8 of 40

2.62

8.04

5.57e-17

MAP-8874081

MET activates PTK2 signaling

5 of 22

2.67

4.84

5.93e-10

MAP-8875878

MET promotes cell motility

5 of 38

2.44

4.23

4.69e-09

MAP-6806834

Signaling by MET

5 of 78

2.12

3.36

8.42e-08

MAP-3000171

Non-integrin membrane-ECM interactions

4 of 51

2.21

2.79

2.70e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

3 of 407

1.19

0.81

0.0076

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005604

Basement membrane

8 of 56

2.47

7.27

6.00e-16

GOCC:0062023

Collagen-containing extracellular matrix

9 of 190

1.99

5.33

9.90e-15

GOCC:0005610

laminin-5 complex

4 of 7

3.07

4.6

3.65e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0424

Laminin EGF-like domain

5 of 38

2.44

4.33

2.83e-09

KW-1015

Disulfide bond

5 of 1351

0.89

0.49

0.0415

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002049

Laminin-type EGF domain

6 of 51

2.39

4.58

5.94e-10

IPR000034

Laminin IV

4 of 6

3.14

4.2

2.16e-08

IPR008211

Laminin, N-terminal

4 of 23

2.56

3.14

1.20e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00180

Laminin-type epidermal growth factor-like domai

6 of 42

2.47

5.32

2.20e-11

SM00136

Laminin N-terminal domain (domain VI)

4 of 22

2.58

3.57

1.67e-07

SM00001

EGF domain, unclasssified subfamily

4 of 92

1.96

2.21

2.44e-05

SM00281

Laminin B domain

2 of 4

3.02

1.78

0.00061

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