LOC103479267 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

LOC103479267

Uncharacterized protein. (1084 aa)

Predicted Functional Partners:

ENSPREP00000015831

0.647

ENSPREP00000015870

0.647

ENSPREP00000015917

0.647

itsn2

0.647

efnb1

0.618

LOC103458404

0.617

EFNA2

0.616

LOC103474014

0.589

EFNA5

0.589

LOC103480564

0.578

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFNA2	EFNA5	ENSPREP00000010721	ENSPREP00000023929	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Ephrin A5; Belongs to the ephrin family.	0.454
EFNA2	LOC103474014	ENSPREP00000010721	ENSPREP00000008564	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Ephrin-A5a; Belongs to the ephrin family.	0.455
EFNA2	LOC103479267	ENSPREP00000010721	ENSPREP00000019054	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Uncharacterized protein.	0.616
EFNA2	LOC103480564	ENSPREP00000010721	ENSPREP00000022301	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Ephrin-B3a; Belongs to the ephrin family.	0.642
EFNA2	efnb1	ENSPREP00000010721	ENSPREP00000031206	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	Ephrin-B1; Belongs to the ephrin family.	0.707
EFNA5	EFNA2	ENSPREP00000023929	ENSPREP00000010721	Ephrin A5; Belongs to the ephrin family.	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	0.454
EFNA5	LOC103458404	ENSPREP00000023929	ENSPREP00000019147	Ephrin A5; Belongs to the ephrin family.	Ephrin-A2a; Belongs to the ephrin family.	0.489
EFNA5	LOC103479267	ENSPREP00000023929	ENSPREP00000019054	Ephrin A5; Belongs to the ephrin family.	Uncharacterized protein.	0.589
EFNA5	LOC103480564	ENSPREP00000023929	ENSPREP00000022301	Ephrin A5; Belongs to the ephrin family.	Ephrin-B3a; Belongs to the ephrin family.	0.707
EFNA5	efnb1	ENSPREP00000023929	ENSPREP00000031206	Ephrin A5; Belongs to the ephrin family.	Ephrin-B1; Belongs to the ephrin family.	0.571
ENSPREP00000015831	ENSPREP00000015870	ENSPREP00000015831	ENSPREP00000015870	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSPREP00000015831	ENSPREP00000015917	ENSPREP00000015831	ENSPREP00000015917	Uncharacterized protein.	EH domain-containing protein.	0.952
ENSPREP00000015831	LOC103479267	ENSPREP00000015831	ENSPREP00000019054	Uncharacterized protein.	Uncharacterized protein.	0.647
ENSPREP00000015831	itsn2	ENSPREP00000015831	ENSPREP00000017512	Uncharacterized protein.	Intersectin 2a.	0.953
ENSPREP00000015870	ENSPREP00000015831	ENSPREP00000015870	ENSPREP00000015831	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSPREP00000015870	ENSPREP00000015917	ENSPREP00000015870	ENSPREP00000015917	Uncharacterized protein.	EH domain-containing protein.	0.952
ENSPREP00000015870	LOC103479267	ENSPREP00000015870	ENSPREP00000019054	Uncharacterized protein.	Uncharacterized protein.	0.647
ENSPREP00000015870	itsn2	ENSPREP00000015870	ENSPREP00000017512	Uncharacterized protein.	Intersectin 2a.	0.952
ENSPREP00000015917	ENSPREP00000015831	ENSPREP00000015917	ENSPREP00000015831	EH domain-containing protein.	Uncharacterized protein.	0.952
ENSPREP00000015917	ENSPREP00000015870	ENSPREP00000015917	ENSPREP00000015870	EH domain-containing protein.	Uncharacterized protein.	0.952

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031072

Heat shock protein binding

3 of 73

1.83

0.82

0.0287

GO:0008276

Protein methyltransferase activity

3 of 78

1.81

0.82

0.0287

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035869

Ciliary transition zone

3 of 70

1.85

1.0

0.0126

GO:0036038

MKS complex

2 of 13

2.41

0.93

0.0226

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:29744

Lysine methyltransferase, and FAM86, N-terminal

4 of 12

2.74

3.52

4.42e-07

CL:16441

MKS complex, and Tectonic

3 of 5

3.0

2.93

6.48e-06

CL:29746

Lysine methyltransferase, and KOW (Kyprides, Ouzounis, Woese) motif.

3 of 6

2.92

2.87

8.09e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8876725

Protein methylation

6 of 22

2.66

6.01

4.49e-12

MAP-156902

Peptide chain elongation

2 of 2

3.22

1.6

0.0016

MAP-156842

Eukaryotic Translation Elongation

2 of 5

2.82

1.38

0.0038

MAP-5358493

Synthesis of diphthamide-EEF2

2 of 9

2.57

1.22

0.0068

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 103

1.68

1.05

0.0081

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

3 of 15

2.52

2.05

0.00020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10294

Lysine methyltransferase

2 of 6

2.74

1.0

0.0177

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019410

Lysine methyltransferase

3 of 8

2.79

2.14

0.00016

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