LOC103457154 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

LOC103457154

Uncharacterized protein. (689 aa)

Predicted Functional Partners:

smo

0.847

sufu

0.818

spopl

0.737

SPOP

0.737

kif7

0.698

ENSPREP00000033818

0.698

gkap1

0.618

KIF27

0.618

kif21b

0.616

fbxw11

0.612

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000033818	KIF27	ENSPREP00000033818	ENSPREP00000027983	Protein kinase domain-containing protein.	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.861
ENSPREP00000033818	LOC103457154	ENSPREP00000033818	ENSPREP00000019383	Protein kinase domain-containing protein.	Uncharacterized protein.	0.698
ENSPREP00000033818	gkap1	ENSPREP00000033818	ENSPREP00000027945	Protein kinase domain-containing protein.	G kinase anchoring protein 1.	0.861
ENSPREP00000033818	kif21b	ENSPREP00000033818	ENSPREP00000003724	Protein kinase domain-containing protein.	Kinesin family member 21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.861
ENSPREP00000033818	kif7	ENSPREP00000033818	ENSPREP00000002876	Protein kinase domain-containing protein.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.861
ENSPREP00000033818	smo	ENSPREP00000033818	ENSPREP00000005932	Protein kinase domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.839
ENSPREP00000033818	sufu	ENSPREP00000033818	ENSPREP00000030739	Protein kinase domain-containing protein.	Suppressor of fused homolog.	0.923
KIF27	ENSPREP00000033818	ENSPREP00000027983	ENSPREP00000033818	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Protein kinase domain-containing protein.	0.861
KIF27	LOC103457154	ENSPREP00000027983	ENSPREP00000019383	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.618
KIF27	smo	ENSPREP00000027983	ENSPREP00000005932	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.748
KIF27	sufu	ENSPREP00000027983	ENSPREP00000030739	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Suppressor of fused homolog.	0.674
LOC103457154	ENSPREP00000033818	ENSPREP00000019383	ENSPREP00000033818	Uncharacterized protein.	Protein kinase domain-containing protein.	0.698
LOC103457154	KIF27	ENSPREP00000019383	ENSPREP00000027983	Uncharacterized protein.	Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.618
LOC103457154	SPOP	ENSPREP00000019383	ENSPREP00000033985	Uncharacterized protein.	Speckle type BTB/POZ protein.	0.737
LOC103457154	fbxw11	ENSPREP00000019383	ENSPREP00000002506	Uncharacterized protein.	F-box and WD repeat domain containing 11a.	0.612
LOC103457154	gkap1	ENSPREP00000019383	ENSPREP00000027945	Uncharacterized protein.	G kinase anchoring protein 1.	0.618
LOC103457154	kif21b	ENSPREP00000019383	ENSPREP00000003724	Uncharacterized protein.	Kinesin family member 21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.616
LOC103457154	kif7	ENSPREP00000019383	ENSPREP00000002876	Uncharacterized protein.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.698
LOC103457154	smo	ENSPREP00000019383	ENSPREP00000005932	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.847
LOC103457154	spopl	ENSPREP00000019383	ENSPREP00000021628	Uncharacterized protein.	Speckle type BTB/POZ protein like b.	0.737

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Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033353

S-adenosylmethionine cycle

3 of 6

3.32

4.18

3.97e-06

GO:0006730

One-carbon metabolic process

3 of 34

2.56

2.9

0.00012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

3.62

5.1

2.79e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30809531

(2019) ITRAQ-Based Quantitative Proteomics Reveals the Proteome Profiles of Primary Duck Embryo Fibroblast Cells Infected with Duck Tembusu Virus.

3 of 15

2.92

3.43

3.13e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7158

Sulfur amino acid biosynthetic process, and Adenosylhomocysteinase-like

3 of 12

3.02

3.86

8.79e-06

CL:7161

Cysteine biosynthetic process, and Adenosylhomocysteinase-like

2 of 5

3.22

2.46

0.00067

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00270

Cysteine and methionine metabolism

3 of 35

2.55

3.73

7.31e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

3.62

4.82

6.35e-07

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

3.62

4.82

6.35e-07

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

4.82

6.35e-07

IPR000043

Adenosylhomocysteinase-like

3 of 3

3.62

4.82

6.35e-07

IPR036291

NAD(P)-binding domain superfamily

3 of 142

1.94

1.7

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

3.62

5.53

7.62e-08

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