cdo1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

cdo1

Cysteine dioxygenase. (202 aa)

Predicted Functional Partners:

cth

0.983

LOC103478943

0.936

LOC103465889

0.936

csad

0.936

gad2

0.935

got2

0.930

GOT1

0.927

kyat3

0.900

kyat1

0.900

gclc

0.808

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GOT1	LOC103465889	ENSPREP00000031324	ENSPREP00000016451	Aspartate aminotransferase.	Glutamate decarboxylase like 1.	0.825
GOT1	LOC103478943	ENSPREP00000031324	ENSPREP00000002937	Aspartate aminotransferase.	Glutamate decarboxylase 1b.	0.825
GOT1	cdo1	ENSPREP00000031324	ENSPREP00000019459	Aspartate aminotransferase.	Cysteine dioxygenase.	0.927
GOT1	csad	ENSPREP00000031324	ENSPREP00000029823	Aspartate aminotransferase.	Cysteine sulfinic acid decarboxylase.	0.825
GOT1	cth	ENSPREP00000031324	ENSPREP00000008678	Aspartate aminotransferase.	Cystathionase (cystathionine gamma-lyase), like.	0.942
GOT1	gad2	ENSPREP00000031324	ENSPREP00000001273	Aspartate aminotransferase.	Glutamate decarboxylase 2.	0.825
GOT1	gclc	ENSPREP00000031324	ENSPREP00000032692	Aspartate aminotransferase.	Glutamate-cysteine ligase, catalytic subunit.	0.808
GOT1	got2	ENSPREP00000031324	ENSPREP00000021995	Aspartate aminotransferase.	Aspartate aminotransferase.	0.967
GOT1	kyat1	ENSPREP00000031324	ENSPREP00000032441	Aspartate aminotransferase.	Kynurenine aminotransferase 1.	0.939
GOT1	kyat3	ENSPREP00000031324	ENSPREP00000021246	Aspartate aminotransferase.	Kynurenine aminotransferase 3.	0.939
LOC103465889	GOT1	ENSPREP00000016451	ENSPREP00000031324	Glutamate decarboxylase like 1.	Aspartate aminotransferase.	0.825
LOC103465889	LOC103478943	ENSPREP00000016451	ENSPREP00000002937	Glutamate decarboxylase like 1.	Glutamate decarboxylase 1b.	0.905
LOC103465889	cdo1	ENSPREP00000016451	ENSPREP00000019459	Glutamate decarboxylase like 1.	Cysteine dioxygenase.	0.936
LOC103465889	csad	ENSPREP00000016451	ENSPREP00000029823	Glutamate decarboxylase like 1.	Cysteine sulfinic acid decarboxylase.	0.901
LOC103465889	gad2	ENSPREP00000016451	ENSPREP00000001273	Glutamate decarboxylase like 1.	Glutamate decarboxylase 2.	0.959
LOC103465889	got2	ENSPREP00000016451	ENSPREP00000021995	Glutamate decarboxylase like 1.	Aspartate aminotransferase.	0.832
LOC103478943	GOT1	ENSPREP00000002937	ENSPREP00000031324	Glutamate decarboxylase 1b.	Aspartate aminotransferase.	0.825
LOC103478943	LOC103465889	ENSPREP00000002937	ENSPREP00000016451	Glutamate decarboxylase 1b.	Glutamate decarboxylase like 1.	0.905
LOC103478943	cdo1	ENSPREP00000002937	ENSPREP00000019459	Glutamate decarboxylase 1b.	Cysteine dioxygenase.	0.936
LOC103478943	csad	ENSPREP00000002937	ENSPREP00000029823	Glutamate decarboxylase 1b.	Cysteine sulfinic acid decarboxylase.	0.905

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.871

expected number of edges:

10

PPI enrichment p-value:

0.000306

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033198

Response to ATP

5 of 14

2.87

5.17

2.21e-10

GO:0032732

Positive regulation of interleukin-1 production

4 of 34

2.39

2.96

1.91e-06

GO:0035590

Purinergic nucleotide receptor signaling pathway

4 of 36

2.36

2.93

2.13e-06

GO:0006812

Cation transport

11 of 975

1.37

2.43

7.37e-12

GO:0002931

Response to ischemia

3 of 17

2.56

2.32

4.77e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035381

ATP-gated ion channel activity

3 of 9

2.84

2.91

4.43e-06

GO:0005261

Cation channel activity

8 of 469

1.55

2.69

2.02e-09

GO:0015267

Channel activity

9 of 648

1.46

2.54

3.54e-10

GO:0008324

Cation transmembrane transporter activity

10 of 823

1.4

2.42

1.11e-10

GO:0001614

Purinergic nucleotide receptor activity

3 of 23

2.43

2.31

4.41e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005639

Integral component of nuclear inner membrane

3 of 12

2.72

2.35

4.73e-05

GO:0005921

Gap junction

3 of 43

2.16

1.91

0.00020

GO:0005911

Cell-cell junction

4 of 389

1.33

0.99

0.0036

GO:0030054

Cell junction

6 of 1752

0.85

0.59

0.0082

GO:0120025

Plasma membrane bounded cell projection

6 of 1857

0.83

0.57

0.0091

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43862

Nucleotide receptor activity, and TMEM119 family

7 of 24

2.78

7.35

6.66e-15

CL:43865

ATP P2X receptor, and Innexin

5 of 10

3.02

5.6

4.43e-11

CL:43868

ATP P2X receptor

2 of 5

2.92

1.25

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04621

NOD-like receptor signaling pathway

3 of 133

1.67

1.09

0.0054

pret04020

Calcium signaling pathway

3 of 250

1.4

0.8

0.0172

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112307

Transmission across Electrical Synapses

3 of 10

2.79

2.4

3.93e-05

MAP-112303

Electric Transmission Across Gap Junctions

3 of 10

2.79

2.4

3.93e-05

MAP-139853

Elevation of cytosolic Ca2+ levels

3 of 21

2.47

2.16

9.24e-05

MAP-844456

The NLRP3 inflammasome

3 of 27

2.36

2.04

0.00014

MAP-9730628

Sensory perception of salty taste

2 of 2

3.32

1.96

0.00030

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005639

Integral component of nuclear inner membrane

3 of 11

2.75

2.36

4.60e-05

GOCC:0005921

Gap junction

3 of 38

2.21

1.8

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0407

Ion channel

6 of 308

1.61

2.26

9.31e-07

KW-0303

Gap junction

3 of 41

2.18

2.16

5.96e-05

KW-0325

Glycoprotein

3 of 61

2.01

1.91

0.00014

KW-1071

Ligand-gated ion channel

2 of 63

1.82

0.94

0.0144

KW-1133

Transmembrane helix

11 of 5706

0.6

0.54

2.64e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00876

Innexin

3 of 4

3.19

2.86

6.58e-06

PF00864

ATP P2X receptor

3 of 7

2.95

2.71

1.13e-05

PF14798

Calcium homeostasis modulator

2 of 5

2.92

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039099

Pannexin

3 of 4

3.19

2.59

2.05e-05

IPR000990

Innexin

3 of 4

3.19

2.59

2.05e-05

IPR027309

P2X purinoreceptor extracellular domain superfamily

3 of 7

2.95

2.54

2.35e-05

IPR001429

P2X purinoreceptor

3 of 7

2.95

2.54

2.35e-05

IPR029569

Calcium homeostasis modulator family

2 of 5

2.92

1.22

0.0063

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