slk protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

slk

STE20-like kinase a. (1157 aa)

Predicted Functional Partners:

LOC103472579

0.901

cdk1

0.900

diaph2

0.540

LOC103462133

0.482

LOC103465968

0.482

myo9b

0.482

LOC103479882

0.475

DIAPH1

0.404

diaph3

0.404

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIAPH1	LOC103462133	ENSPREP00000027977	ENSPREP00000009559	Diaphanous related formin 1.	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.526
DIAPH1	LOC103465968	ENSPREP00000027977	ENSPREP00000019934	Diaphanous related formin 1.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.526
DIAPH1	LOC103472579	ENSPREP00000027977	ENSPREP00000004056	Diaphanous related formin 1.	STE20-like kinase b.	0.404
DIAPH1	LOC103479882	ENSPREP00000027977	ENSPREP00000019878	Diaphanous related formin 1.	Myosin IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.526
DIAPH1	diaph2	ENSPREP00000027977	ENSPREP00000018422	Diaphanous related formin 1.	Diaphanous-related formin 2.	0.901
DIAPH1	myo9b	ENSPREP00000027977	ENSPREP00000025222	Diaphanous related formin 1.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.526
DIAPH1	slk	ENSPREP00000027977	ENSPREP00000019464	Diaphanous related formin 1.	STE20-like kinase a.	0.404
LOC103462133	DIAPH1	ENSPREP00000009559	ENSPREP00000027977	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Diaphanous related formin 1.	0.526
LOC103462133	LOC103472579	ENSPREP00000009559	ENSPREP00000004056	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	STE20-like kinase b.	0.482
LOC103462133	diaph2	ENSPREP00000009559	ENSPREP00000018422	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Diaphanous-related formin 2.	0.526
LOC103462133	diaph3	ENSPREP00000009559	ENSPREP00000031470	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Diaphanous-related formin 3.	0.526
LOC103462133	slk	ENSPREP00000009559	ENSPREP00000019464	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	STE20-like kinase a.	0.482
LOC103465968	DIAPH1	ENSPREP00000019934	ENSPREP00000027977	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Diaphanous related formin 1.	0.526
LOC103465968	LOC103472579	ENSPREP00000019934	ENSPREP00000004056	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	STE20-like kinase b.	0.482
LOC103465968	diaph2	ENSPREP00000019934	ENSPREP00000018422	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Diaphanous-related formin 2.	0.526
LOC103465968	diaph3	ENSPREP00000019934	ENSPREP00000031470	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Diaphanous-related formin 3.	0.526
LOC103465968	slk	ENSPREP00000019934	ENSPREP00000019464	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	STE20-like kinase a.	0.482
LOC103472579	DIAPH1	ENSPREP00000004056	ENSPREP00000027977	STE20-like kinase b.	Diaphanous related formin 1.	0.404
LOC103472579	LOC103462133	ENSPREP00000004056	ENSPREP00000009559	STE20-like kinase b.	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.482
LOC103472579	LOC103465968	ENSPREP00000004056	ENSPREP00000019934	STE20-like kinase b.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.482

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008333

Endosome to lysosome transport

7 of 57

2.41

5.83

8.48e-13

GO:0007034

Vacuolar transport

9 of 145

2.11

5.76

9.93e-15

GO:0034058

Endosomal vesicle fusion

5 of 10

3.02

5.6

4.31e-11

GO:0048284

Organelle fusion

8 of 112

2.17

5.47

3.00e-13

GO:0006906

Vesicle fusion

6 of 86

2.16

4.07

1.89e-09

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030897

HOPS complex

6 of 8

3.19

7.78

4.39e-15

GO:0099023

Vesicle tethering complex

8 of 60

2.44

7.14

8.23e-16

GO:0033263

CORVET complex

5 of 6

3.24

6.54

1.03e-12

GO:0005770

Late endosome

9 of 221

1.93

5.02

1.54e-14

GO:0031902

Late endosome membrane

7 of 123

2.07

4.69

1.11e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14867

Mixed, incl. CORVET complex, and Rab9

10 of 19

3.04

12.98

1.02e-25

CL:14869

CORVET complex, and Vacuolar HOPS complex

9 of 11

3.23

12.54

3.27e-24

CL:14873

HOPS complex

6 of 6

3.32

8.04

1.79e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret05132

Salmonella infection

6 of 240

1.72

2.7

1.07e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

6 of 100

2.1

3.76

6.48e-09

MAP-1643685

Disease

6 of 185

1.83

2.89

1.16e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0099023

Vesicle tethering complex

7 of 63

2.36

5.74

9.26e-13

GOCC:0030897

HOPS complex

4 of 5

3.22

4.7

2.79e-09

GOCC:0033263

CORVET complex

3 of 4

3.19

3.21

1.48e-06

GOCC:0005768

Endosome

5 of 327

1.5

1.58

0.00010

GOCC:0005776

Autophagosome

2 of 56

1.87

0.72

0.0437

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0967

Endosome

3 of 8

2.89

2.92

4.55e-06

KW-0458

Lysosome

3 of 14

2.65

2.71

9.37e-06

KW-0653

Protein transport

3 of 115

1.73

1.26

0.0024

KW-0968

Cytoplasmic vesicle

2 of 25

2.22

1.18

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00637

Region in Clathrin and VPS

3 of 3

3.32

3.0

3.76e-06

PF10367

Vacuolar sorting protein 39 domain 2

2 of 2

3.32

1.59

0.0014

PF10366

Vacuolar sorting protein 39 domain 1

2 of 2

3.32

1.59

0.0014

PF00780

CNH domain

2 of 6

2.84

1.37

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000547

Clathrin, heavy chain/VPS, 7-fold repeat

5 of 8

3.11

5.49

8.09e-11

IPR036322

WD40-repeat-containing domain superfamily

5 of 291

1.55

1.4

0.00054

IPR045111

Vacuolar protein sorting-associated protein Vps41/Vps8

2 of 2

3.32

1.4

0.0030

IPR032914

Vam6/VPS39/TRAP1 family

2 of 2

3.32

1.4

0.0030

IPR019453

Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2

2 of 2

3.32

1.4

0.0030

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00184

Ring finger

4 of 434

1.28

0.67

0.0306

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