LOC103477399 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

LOC103477399

Uncharacterized protein. (90 aa)

Predicted Functional Partners:

lemd3

0.803

ankle2

0.795

lmnb2

0.746

lmnb1

0.737

LOC103473032

0.733

lmna

0.733

LOC103461139

0.708

rbm39

0.708

LOC103477297

0.705

vrk1

0.705

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103461139	LOC103473032	ENSPREP00000022454	ENSPREP00000013523	RNA binding motif protein 39b.	Uncharacterized protein; Belongs to the intermediate filament family.	0.510
LOC103461139	LOC103477399	ENSPREP00000022454	ENSPREP00000019489	RNA binding motif protein 39b.	Uncharacterized protein.	0.708
LOC103461139	ankle2	ENSPREP00000022454	ENSPREP00000028304	RNA binding motif protein 39b.	Ankyrin repeat and LEM domain containing 2.	0.436
LOC103461139	lmna	ENSPREP00000022454	ENSPREP00000025569	RNA binding motif protein 39b.	Lamin A; Belongs to the intermediate filament family.	0.510
LOC103461139	lmnb1	ENSPREP00000022454	ENSPREP00000006678	RNA binding motif protein 39b.	Lamin B1; Belongs to the intermediate filament family.	0.523
LOC103461139	lmnb2	ENSPREP00000022454	ENSPREP00000030057	RNA binding motif protein 39b.	Lamin B2; Belongs to the intermediate filament family.	0.520
LOC103473032	LOC103461139	ENSPREP00000013523	ENSPREP00000022454	Uncharacterized protein; Belongs to the intermediate filament family.	RNA binding motif protein 39b.	0.510
LOC103473032	LOC103477399	ENSPREP00000013523	ENSPREP00000019489	Uncharacterized protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.733
LOC103473032	ankle2	ENSPREP00000013523	ENSPREP00000028304	Uncharacterized protein; Belongs to the intermediate filament family.	Ankyrin repeat and LEM domain containing 2.	0.411
LOC103473032	lemd3	ENSPREP00000013523	ENSPREP00000026156	Uncharacterized protein; Belongs to the intermediate filament family.	LEM domain containing 3.	0.690
LOC103473032	rbm39	ENSPREP00000013523	ENSPREP00000031203	Uncharacterized protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.510
LOC103477297	LOC103477399	ENSPREP00000014320	ENSPREP00000019489	VRK serine/threonine kinase 2.	Uncharacterized protein.	0.705
LOC103477297	ankle2	ENSPREP00000014320	ENSPREP00000028304	VRK serine/threonine kinase 2.	Ankyrin repeat and LEM domain containing 2.	0.829
LOC103477399	LOC103461139	ENSPREP00000019489	ENSPREP00000022454	Uncharacterized protein.	RNA binding motif protein 39b.	0.708
LOC103477399	LOC103473032	ENSPREP00000019489	ENSPREP00000013523	Uncharacterized protein.	Uncharacterized protein; Belongs to the intermediate filament family.	0.733
LOC103477399	LOC103477297	ENSPREP00000019489	ENSPREP00000014320	Uncharacterized protein.	VRK serine/threonine kinase 2.	0.705
LOC103477399	ankle2	ENSPREP00000019489	ENSPREP00000028304	Uncharacterized protein.	Ankyrin repeat and LEM domain containing 2.	0.795
LOC103477399	lemd3	ENSPREP00000019489	ENSPREP00000026156	Uncharacterized protein.	LEM domain containing 3.	0.803
LOC103477399	lmna	ENSPREP00000019489	ENSPREP00000025569	Uncharacterized protein.	Lamin A; Belongs to the intermediate filament family.	0.733
LOC103477399	lmnb1	ENSPREP00000019489	ENSPREP00000006678	Uncharacterized protein.	Lamin B1; Belongs to the intermediate filament family.	0.737

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.845

expected number of edges:

10

PPI enrichment p-value:

6.32e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006810

Transport

11 of 644

1.0

1.22

1.78e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036094

Small molecule binding

8 of 978

0.68

0.42

0.0283

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030288

Outer membrane-bounded periplasmic space

3 of 25

1.84

1.35

0.0019

GO:0005886

Plasma membrane

9 of 1856

0.45

0.33

0.0139

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8072

Mixed, incl. ABC transporter, permease protein, BtuC-like, and Periplasmic binding protein

10 of 26

2.35

8.42

4.14e-20

CL:8071

Mixed, incl. ABC transporter, permease protein, BtuC-like, and Periplasmic binding protein

11 of 36

2.25

8.41

1.33e-21

CL:8073

ABC transporter, permease protein, BtuC-like, and Periplasmic binding protein

9 of 20

2.42

8.04

2.60e-18

CL:8074

ABC transporter, permease protein, BtuC-like, and Periplasmic binding protein

5 of 12

2.38

4.12

6.41e-09

CL:8098

Mixed, incl. FecCD transport family, and Transmembrane secretion effector

4 of 7

2.52

3.44

2.75e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030288

Outer membrane-bounded periplasmic space

3 of 45

1.59

1.05

0.0057

GOCC:0005886

Plasma membrane

8 of 615

0.88

0.77

0.00035

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

6 of 323

1.03

0.85

0.0014

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01497

Periplasmic binding protein

3 of 8

2.34

1.77

0.00047

PF01032

FecCD transport family

2 of 8

2.16

0.73

0.0458

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017871

ABC transporter-like, conserved site

6 of 92

1.58

1.96

9.05e-06

IPR002491

ABC transporter periplasmic binding domain

3 of 8

2.34

1.87

0.00029

IPR003439

ABC transporter-like, ATP-binding domain

6 of 111

1.5

1.8

1.33e-05

IPR003593

AAA+ ATPase domain

6 of 150

1.37

1.49

5.00e-05

IPR027417

P-loop containing nucleoside triphosphate hydrolase

6 of 310

1.05

0.84

0.0020

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

6 of 144

1.38

1.68

8.74e-06

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