ENSPREP00000019557 protein (Poecilia reticulata)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ENSPREP00000019557

ATCAY kinesin light chain interacting caytaxin b. (308 aa)

Predicted Functional Partners:

arhgap1

0.725

apc2

0.716

apc

0.716

uprt

0.709

ctnnbip1

0.694

bcl2

0.676

leo1

0.667

csnk1a1

0.627

skp1

0.606

ruvbl1

0.604

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000019557	apc	ENSPREP00000019557	ENSPREP00000025269	ATCAY kinesin light chain interacting caytaxin b.	APC regulator of WNT signaling pathway.	0.716
ENSPREP00000019557	apc2	ENSPREP00000019557	ENSPREP00000001048	ATCAY kinesin light chain interacting caytaxin b.	APC regulator of WNT signaling pathway 2.	0.716
ENSPREP00000019557	arhgap1	ENSPREP00000019557	ENSPREP00000026198	ATCAY kinesin light chain interacting caytaxin b.	Uncharacterized protein.	0.725
ENSPREP00000019557	bcl2	ENSPREP00000019557	ENSPREP00000006116	ATCAY kinesin light chain interacting caytaxin b.	BCL2 apoptosis regulator b.	0.676
ENSPREP00000019557	csnk1a1	ENSPREP00000019557	ENSPREP00000003942	ATCAY kinesin light chain interacting caytaxin b.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.627
ENSPREP00000019557	ctnnbip1	ENSPREP00000019557	ENSPREP00000022926	ATCAY kinesin light chain interacting caytaxin b.	Catenin, beta interacting protein 1.	0.694
ENSPREP00000019557	leo1	ENSPREP00000019557	ENSPREP00000027692	ATCAY kinesin light chain interacting caytaxin b.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.667
ENSPREP00000019557	ruvbl1	ENSPREP00000019557	ENSPREP00000018143	ATCAY kinesin light chain interacting caytaxin b.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.604
ENSPREP00000019557	skp1	ENSPREP00000019557	ENSPREP00000007574	ATCAY kinesin light chain interacting caytaxin b.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.606
ENSPREP00000019557	uprt	ENSPREP00000019557	ENSPREP00000006480	ATCAY kinesin light chain interacting caytaxin b.	Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae).	0.709
apc	ENSPREP00000019557	ENSPREP00000025269	ENSPREP00000019557	APC regulator of WNT signaling pathway.	ATCAY kinesin light chain interacting caytaxin b.	0.716
apc	apc2	ENSPREP00000025269	ENSPREP00000001048	APC regulator of WNT signaling pathway.	APC regulator of WNT signaling pathway 2.	0.900
apc	csnk1a1	ENSPREP00000025269	ENSPREP00000003942	APC regulator of WNT signaling pathway.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.771
apc	ctnnbip1	ENSPREP00000025269	ENSPREP00000022926	APC regulator of WNT signaling pathway.	Catenin, beta interacting protein 1.	0.654
apc	skp1	ENSPREP00000025269	ENSPREP00000007574	APC regulator of WNT signaling pathway.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.962
apc2	ENSPREP00000019557	ENSPREP00000001048	ENSPREP00000019557	APC regulator of WNT signaling pathway 2.	ATCAY kinesin light chain interacting caytaxin b.	0.716
apc2	apc	ENSPREP00000001048	ENSPREP00000025269	APC regulator of WNT signaling pathway 2.	APC regulator of WNT signaling pathway.	0.900
apc2	csnk1a1	ENSPREP00000001048	ENSPREP00000003942	APC regulator of WNT signaling pathway 2.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.771
apc2	ctnnbip1	ENSPREP00000001048	ENSPREP00000022926	APC regulator of WNT signaling pathway 2.	Catenin, beta interacting protein 1.	0.654
apc2	skp1	ENSPREP00000001048	ENSPREP00000007574	APC regulator of WNT signaling pathway 2.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.962

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.589

expected number of edges:

10

PPI enrichment p-value:

7.05e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

4 of 8

3.02

3.79

1.16e-07

GO:0098974

Postsynaptic actin cytoskeleton organization

4 of 15

2.74

3.41

4.54e-07

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

4 of 15

2.74

3.41

4.54e-07

GO:1901385

Regulation of voltage-gated calcium channel activity

4 of 39

2.33

2.78

4.11e-06

GO:0002027

Regulation of heart rate

4 of 40

2.32

2.77

4.11e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

4 of 8

3.02

4.04

3.84e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

4 of 14

2.77

3.74

1.11e-07

GO:0002102

Podosome

4 of 18

2.66

3.66

1.33e-07

GO:0033017

Sarcoplasmic reticulum membrane

4 of 31

2.43

3.28

4.74e-07

GO:0030175

Filopodium

4 of 72

2.06

2.57

5.11e-06

GO:0030018

Z disc

4 of 102

1.91

2.24

1.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36908

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF hand

7 of 31

2.67

6.88

3.20e-14

CL:36910

EF hand, and Syntrophin

4 of 12

2.84

3.88

6.57e-08

CL:36947

Mixed, incl. Torsin 1/2, and Torsin-1A-interacting protein 1/2

3 of 10

2.79

2.56

1.97e-05

CL:36950

Nitric-oxide synthase binding, and Torsin 1/2

2 of 5

2.92

1.39

0.0031

CL:36912

Mixed, incl. EF hand, and Syntrophin, split Pleckstrin homology (PH) domain

2 of 7

2.77

1.28

0.0047

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 407

1.31

1.26

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016010

Dystrophin-associated glycoprotein complex

5 of 24

2.64

4.6

1.60e-09

GOCC:0045202

Synapse

4 of 531

1.19

0.68

0.0232

GOCC:0016020

Membrane

9 of 5135

0.56

0.38

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015482

Syntrophin

4 of 4

3.32

4.32

1.44e-08

IPR041428

Syntrophin, split Pleckstrin homology (PH) domain

3 of 3

3.32

2.98

4.04e-06

IPR011993

PH-like domain superfamily

7 of 529

1.44

1.83

4.04e-06

IPR006020

PTB/PI domain

3 of 57

2.04

1.28

0.0035

IPR001478

PDZ domain

4 of 201

1.62

1.15

0.0035

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 39

2.2

1.64

0.00073

SM00233

Pleckstrin homology domain.

4 of 325

1.41

0.99

0.0050

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