reck protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

reck

Reversion-inducing-cysteine-rich protein with kazal motifs. (974 aa)

Predicted Functional Partners:

brca2

0.549

adgra2

0.469

brca1

0.467

TIMP3

0.458

ENSPREP00000028029

0.430

prdm2

0.426

LOC103467994

0.426

bivm

0.414

ercc5

0.414

pdcd4

0.408

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000028029	reck	ENSPREP00000028029	ENSPREP00000019668	Tetraspanin.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.430
LOC103467994	brca2	ENSPREP00000033739	ENSPREP00000018297	PR domain containing 2, with ZNF domain a.	BRCA2 DNA repair associated.	0.426
LOC103467994	reck	ENSPREP00000033739	ENSPREP00000019668	PR domain containing 2, with ZNF domain a.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.426
TIMP3	reck	ENSPREP00000023839	ENSPREP00000019668	TIMP metallopeptidase inhibitor 3.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.458
adgra2	reck	ENSPREP00000010732	ENSPREP00000019668	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.469
bivm	brca1	ENSPREP00000025122	ENSPREP00000033076	Basic, immunoglobulin-like variable motif containing.	Uncharacterized protein.	0.618
bivm	brca2	ENSPREP00000025122	ENSPREP00000018297	Basic, immunoglobulin-like variable motif containing.	BRCA2 DNA repair associated.	0.692
bivm	ercc5	ENSPREP00000025122	ENSPREP00000032160	Basic, immunoglobulin-like variable motif containing.	Excision repair cross-complementation group 5.	0.664
bivm	reck	ENSPREP00000025122	ENSPREP00000019668	Basic, immunoglobulin-like variable motif containing.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.414
brca1	bivm	ENSPREP00000033076	ENSPREP00000025122	Uncharacterized protein.	Basic, immunoglobulin-like variable motif containing.	0.618
brca1	brca2	ENSPREP00000033076	ENSPREP00000018297	Uncharacterized protein.	BRCA2 DNA repair associated.	0.998
brca1	ercc5	ENSPREP00000033076	ENSPREP00000032160	Uncharacterized protein.	Excision repair cross-complementation group 5.	0.653
brca1	reck	ENSPREP00000033076	ENSPREP00000019668	Uncharacterized protein.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.467
brca2	LOC103467994	ENSPREP00000018297	ENSPREP00000033739	BRCA2 DNA repair associated.	PR domain containing 2, with ZNF domain a.	0.426
brca2	bivm	ENSPREP00000018297	ENSPREP00000025122	BRCA2 DNA repair associated.	Basic, immunoglobulin-like variable motif containing.	0.692
brca2	brca1	ENSPREP00000018297	ENSPREP00000033076	BRCA2 DNA repair associated.	Uncharacterized protein.	0.998
brca2	ercc5	ENSPREP00000018297	ENSPREP00000032160	BRCA2 DNA repair associated.	Excision repair cross-complementation group 5.	0.692
brca2	prdm2	ENSPREP00000018297	ENSPREP00000007669	BRCA2 DNA repair associated.	PR domain containing 2, with ZNF domain b.	0.426
brca2	reck	ENSPREP00000018297	ENSPREP00000019668	BRCA2 DNA repair associated.	Reversion-inducing-cysteine-rich protein with kazal motifs.	0.549
ercc5	bivm	ENSPREP00000032160	ENSPREP00000025122	Excision repair cross-complementation group 5.	Basic, immunoglobulin-like variable motif containing.	0.664

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.673

expected number of edges:

16

PPI enrichment p-value:

0.00301

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051607

Defense response to virus

6 of 7

2.56

5.88

2.70e-11

GO:0043571

Maintenance of CRISPR repeat elements

4 of 4

2.63

4.08

9.56e-08

GO:0090304

Nucleic acid metabolic process

6 of 348

0.86

0.69

0.0019

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004518

Nuclease activity

5 of 54

1.59

1.87

4.69e-05

GO:0004519

Endonuclease activity

3 of 31

1.61

1.03

0.0108

GO:0016787

Hydrolase activity

6 of 477

0.73

0.45

0.0286

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6451

Response to virus, and Maintenance of DNA repeat elements

8 of 8

2.63

8.95

2.22e-17

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0051

Antiviral defense

3 of 3

2.63

2.67

3.20e-05

KW-0540

Nuclease

4 of 29

1.77

2.08

4.72e-05

KW-0269

Exonuclease

2 of 10

1.93

0.98

0.0197

KW-0464

Manganese

2 of 20

1.63

0.76

0.0422

KW-0255

Endonuclease

2 of 18

1.67

0.76

0.0422

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01930

Domain of unknown function DUF83

2 of 2

2.63

1.12

0.0146

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR022765

Dna2/Cas4, domain of unknown function DUF83

2 of 2

2.63

0.87

0.0380

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