dnttip2 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

dnttip2

Deoxynucleotidyltransferase, terminal, interacting protein 2. (833 aa)

Predicted Functional Partners:

aatf

0.994

utp11

0.993

bms1

0.992

wdr36

0.992

utp3

0.991

LOC103482313

0.990

nop58

0.989

mphosph10

0.988

fcf1

0.987

wdr43

0.986

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103482313	aatf	ENSPREP00000016575	ENSPREP00000019969	Neuroguidin, EIF4E binding protein.	Apoptosis antagonizing transcription factor.	0.997
LOC103482313	bms1	ENSPREP00000016575	ENSPREP00000003768	Neuroguidin, EIF4E binding protein.	BMS1 ribosome biogenesis factor.	0.997
LOC103482313	dnttip2	ENSPREP00000016575	ENSPREP00000019861	Neuroguidin, EIF4E binding protein.	Deoxynucleotidyltransferase, terminal, interacting protein 2.	0.990
LOC103482313	fcf1	ENSPREP00000016575	ENSPREP00000028423	Neuroguidin, EIF4E binding protein.	FCF1 rRNA-processing protein.	0.987
LOC103482313	mphosph10	ENSPREP00000016575	ENSPREP00000033437	Neuroguidin, EIF4E binding protein.	U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.	0.986
LOC103482313	nop58	ENSPREP00000016575	ENSPREP00000020896	Neuroguidin, EIF4E binding protein.	NOP58 ribonucleoprotein homolog (yeast).	0.990
LOC103482313	utp11	ENSPREP00000016575	ENSPREP00000008892	Neuroguidin, EIF4E binding protein.	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.996
LOC103482313	utp3	ENSPREP00000016575	ENSPREP00000007790	Neuroguidin, EIF4E binding protein.	UTP3 small subunit processome component.	0.994
LOC103482313	wdr36	ENSPREP00000016575	ENSPREP00000025383	Neuroguidin, EIF4E binding protein.	WD repeat domain 36.	0.994
LOC103482313	wdr43	ENSPREP00000016575	ENSPREP00000007191	Neuroguidin, EIF4E binding protein.	WD repeat domain 43.	0.998
aatf	LOC103482313	ENSPREP00000019969	ENSPREP00000016575	Apoptosis antagonizing transcription factor.	Neuroguidin, EIF4E binding protein.	0.997
aatf	bms1	ENSPREP00000019969	ENSPREP00000003768	Apoptosis antagonizing transcription factor.	BMS1 ribosome biogenesis factor.	0.997
aatf	dnttip2	ENSPREP00000019969	ENSPREP00000019861	Apoptosis antagonizing transcription factor.	Deoxynucleotidyltransferase, terminal, interacting protein 2.	0.994
aatf	fcf1	ENSPREP00000019969	ENSPREP00000028423	Apoptosis antagonizing transcription factor.	FCF1 rRNA-processing protein.	0.992
aatf	mphosph10	ENSPREP00000019969	ENSPREP00000033437	Apoptosis antagonizing transcription factor.	U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.	0.992
aatf	nop58	ENSPREP00000019969	ENSPREP00000020896	Apoptosis antagonizing transcription factor.	NOP58 ribonucleoprotein homolog (yeast).	0.996
aatf	utp11	ENSPREP00000019969	ENSPREP00000008892	Apoptosis antagonizing transcription factor.	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.995
aatf	utp3	ENSPREP00000019969	ENSPREP00000007790	Apoptosis antagonizing transcription factor.	UTP3 small subunit processome component.	0.995
aatf	wdr36	ENSPREP00000019969	ENSPREP00000025383	Apoptosis antagonizing transcription factor.	WD repeat domain 36.	0.994
aatf	wdr43	ENSPREP00000019969	ENSPREP00000007191	Apoptosis antagonizing transcription factor.	WD repeat domain 43.	0.997

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.782

expected number of edges:

13

PPI enrichment p-value:

1.62e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0150007

Clathrin-dependent synaptic vesicle endocytosis

4 of 7

3.07

3.89

7.75e-08

GO:0036465

Synaptic vesicle recycling

5 of 58

2.25

3.42

1.25e-07

GO:0060996

Dendritic spine development

3 of 16

2.59

2.3

5.40e-05

GO:0030032

Lamellipodium assembly

3 of 23

2.43

2.07

0.00013

GO:0120036

Plasma membrane bounded cell projection organization

6 of 998

1.1

0.91

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005085

Guanyl-nucleotide exchange factor activity

7 of 263

1.74

2.92

2.51e-08

GO:0030695

GTPase regulator activity

8 of 555

1.48

2.31

2.66e-08

GO:0030234

Enzyme regulator activity

9 of 1134

1.22

1.65

6.36e-08

GO:0031267

Small GTPase binding

4 of 265

1.5

1.14

0.0026

GO:0060090

Molecular adaptor activity

4 of 369

1.35

0.92

0.0070

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005905

Clathrin-coated pit

4 of 60

2.14

2.47

1.14e-05

GO:0098793

Presynapse

5 of 396

1.42

1.4

0.00022

GO:0045202

Synapse

8 of 1097

1.18

1.38

5.29e-06

GO:0030027

Lamellipodium

3 of 140

1.65

0.98

0.0096

GO:0014069

Postsynaptic density

3 of 197

1.5

0.79

0.0217

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33082387

(2020) Unveiling the effect of dietary essential oils supplementation in Sparus aurata gills and its efficiency against the infestation by Sparicotyle chrysophrii.

2 of 13

2.5

0.96

0.0181

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12844

RHOU GTPase cycle, and RasGAP C-terminus

7 of 25

2.76

7.28

8.53e-15

CL:12847

p21 activated kinase binding domain, and Cytoplasmic protein NCK

5 of 11

2.98

5.65

3.22e-11

CL:12850

Unstructured region one on RhoGEF 6 and 7, and p21 activated kinase binding domain

4 of 6

3.14

4.64

3.37e-09

CL:14937

Clathrin-dependent endocytosis, and Clathrin coat

4 of 59

2.15

2.53

8.50e-06

CL:14956

Clathrin coat of coated pit, and Clathrin-dependent synaptic vesicle endocytosis

3 of 18

2.54

2.33

4.56e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04810

Regulation of actin cytoskeleton

4 of 239

1.54

1.37

0.00064

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013420

RHOU GTPase cycle

11 of 53

2.63

11.83

5.54e-26

MAP-3928664

Ephrin signaling

5 of 22

2.67

5.07

1.98e-10

MAP-9013424

RHOV GTPase cycle

6 of 67

2.27

4.7

1.30e-10

MAP-9013406

RHOQ GTPase cycle

6 of 85

2.17

4.35

3.63e-10

MAP-9013148

CDC42 GTPase cycle

6 of 199

1.8

2.98

3.97e-08

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 13032

0.24

0.23

0.0187

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0728

SH3 domain

5 of 251

1.62

1.88

2.47e-05

KW-0723

Serine/threonine-protein kinase

3 of 233

1.43

0.73

0.0281

KW-0344

Guanine-nucleotide releasing factor

2 of 63

1.82

0.69

0.0479

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16614

Unstructured region two on RhoGEF 6 and 7

3 of 3

3.32

3.0

3.76e-06

PF16615

Unstructured region one on RhoGEF 6 and 7

2 of 2

3.32

1.59

0.0014

PF16523

betaPIX coiled coil

2 of 2

3.32

1.59

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046376

RhoGEF 6/7, PH domain

3 of 3

3.32

2.99

3.91e-06

IPR000219

Dbl homology (DH) domain

5 of 91

2.06

2.62

3.77e-06

IPR035899

Dbl homology (DH) domain superfamily

5 of 93

2.05

2.61

3.77e-06

IPR033923

p21 activated kinase binding domain

3 of 7

2.95

2.61

1.76e-05

IPR036936

CRIB domain superfamily

3 of 12

2.72

2.32

5.33e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00285

P21-Rho-binding domain

3 of 17

2.56

2.35

4.26e-05

SM00325

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

4 of 80

2.02

2.14

4.26e-05

SM00326

Src homology 3 domains

5 of 258

1.6

1.8

4.26e-05

SM00233

Pleckstrin homology domain.

5 of 325

1.5

1.66

5.08e-05

SM00220

Serine/Threonine protein kinases, catalytic domain

3 of 273

1.36

0.64

0.0415

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