LOC103465968 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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LOC103465968

Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2459 aa)

Predicted Functional Partners:

arhgap1

0.944

actr2

0.678

LOC103475930

0.678

arpc3

0.661

RHOG

0.660

ENSPREP00000010679

0.660

LOC103471173

0.660

LOC103474743

0.659

CDC42

0.659

cltc

0.659

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSPREP00000010679	ENSPREP00000005959	ENSPREP00000010679	Cell division cycle 42.	Ras homolog gene family, member Gd.	0.444
CDC42	LOC103465968	ENSPREP00000005959	ENSPREP00000019934	Cell division cycle 42.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.659
CDC42	LOC103471173	ENSPREP00000005959	ENSPREP00000010689	Cell division cycle 42.	Uncharacterized protein.	0.454
CDC42	LOC103474743	ENSPREP00000005959	ENSPREP00000005547	Cell division cycle 42.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.437
CDC42	LOC103475930	ENSPREP00000005959	ENSPREP00000004360	Cell division cycle 42.	Zgc:101810; Belongs to the actin family.	0.668
CDC42	RHOG	ENSPREP00000005959	ENSPREP00000001999	Cell division cycle 42.	Ras homolog family member G.	0.446
CDC42	actr2	ENSPREP00000005959	ENSPREP00000000805	Cell division cycle 42.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.668
CDC42	arhgap1	ENSPREP00000005959	ENSPREP00000026198	Cell division cycle 42.	Uncharacterized protein.	0.959
CDC42	arpc3	ENSPREP00000005959	ENSPREP00000010288	Cell division cycle 42.	Actin related protein 2/3 complex, subunit 3.	0.656
CDC42	cltc	ENSPREP00000005959	ENSPREP00000013182	Cell division cycle 42.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.437
ENSPREP00000010679	CDC42	ENSPREP00000010679	ENSPREP00000005959	Ras homolog gene family, member Gd.	Cell division cycle 42.	0.444
ENSPREP00000010679	LOC103465968	ENSPREP00000010679	ENSPREP00000019934	Ras homolog gene family, member Gd.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.660
ENSPREP00000010679	LOC103471173	ENSPREP00000010679	ENSPREP00000010689	Ras homolog gene family, member Gd.	Uncharacterized protein.	0.902
ENSPREP00000010679	LOC103475930	ENSPREP00000010679	ENSPREP00000004360	Ras homolog gene family, member Gd.	Zgc:101810; Belongs to the actin family.	0.434
ENSPREP00000010679	RHOG	ENSPREP00000010679	ENSPREP00000001999	Ras homolog gene family, member Gd.	Ras homolog family member G.	0.901
ENSPREP00000010679	actr2	ENSPREP00000010679	ENSPREP00000000805	Ras homolog gene family, member Gd.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.434
ENSPREP00000010679	arhgap1	ENSPREP00000010679	ENSPREP00000026198	Ras homolog gene family, member Gd.	Uncharacterized protein.	0.615
ENSPREP00000010679	arpc3	ENSPREP00000010679	ENSPREP00000010288	Ras homolog gene family, member Gd.	Actin related protein 2/3 complex, subunit 3.	0.421
LOC103465968	CDC42	ENSPREP00000019934	ENSPREP00000005959	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Cell division cycle 42.	0.659
LOC103465968	ENSPREP00000010679	ENSPREP00000019934	ENSPREP00000010679	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Ras homolog gene family, member Gd.	0.660

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Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.562

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045664

Regulation of neuron differentiation

6 of 80

2.19

3.85

8.75e-09

GO:0045666

Positive regulation of neuron differentiation

5 of 40

2.41

3.76

4.36e-08

GO:0001711

Endodermal cell fate commitment

2 of 3

3.14

1.83

0.00049

GO:0045597

Positive regulation of cell differentiation

6 of 478

1.42

1.69

1.34e-05

GO:0045944

Positive regulation of transcription by RNA polymerase II

8 of 880

1.28

1.66

7.57e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

7 of 32

2.66

6.95

2.09e-14

GO:0008134

Transcription factor binding

7 of 358

1.61

2.49

1.04e-07

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 252

1.69

2.43

7.66e-07

GO:0046982

Protein heterodimerization activity

6 of 258

1.68

2.41

7.66e-07

GO:0046983

Protein dimerization activity

7 of 842

1.24

1.42

1.23e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 371

1.59

2.44

1.25e-07

GO:0016593

Cdc73/Paf1 complex

2 of 9

2.66

1.27

0.0048

GO:0005721

Pericentric heterochromatin

2 of 18

2.36

1.03

0.0125

GO:0005634

Nucleus

11 of 6688

0.53

0.43

0.00085

GO:0032991

Protein-containing complex

9 of 5100

0.56

0.39

0.0125

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36459298

(2022) Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.

2 of 20

2.32

0.77

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31959

Myogenesis, and DNA-binding protein inhibitor

6 of 24

2.72

5.82

6.88e-12

CL:31867

Mixed, incl. Helix-loop-helix DNA-binding domain superfamily, and RUNX1 regulates transcription of genes involved in differentiation of HSCs

7 of 114

2.11

4.48

7.89e-11

CL:31960

MADS MEF2-like, and Myogenic factor

3 of 15

2.62

2.36

4.20e-05

CL:10560

Endodermal cell fate commitment, and Spinal cord oligodendrocyte cell differentiation

2 of 5

2.92

1.45

0.0024

CL:31990

DNA-binding protein inhibitor, and Positive regulation of skeletal muscle fiber development

2 of 6

2.84

1.4

0.0029

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

5 of 54

2.28

3.55

7.30e-08

MAP-1266738

Developmental Biology

6 of 811

1.19

1.06

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

2 of 8

2.72

1.23

0.0058

GOCC:0005721

Pericentric heterochromatin

2 of 7

2.77

1.23

0.0058

GOCC:0005634

Nucleus

9 of 3523

0.72

0.55

0.0031

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.3

0.0150

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

5 of 144

1.86

2.07

3.49e-05

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

5 of 145

1.86

2.07

3.49e-05

IPR008251

Chromo shadow domain

2 of 5

2.92

1.1

0.0104

IPR017984

Chromo domain subgroup

2 of 10

2.62

0.89

0.0246

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

5 of 149

1.84

2.38

4.51e-06

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