kcnc2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

kcnc2

Potassium voltage-gated channel, Shaw-related subfamily, member 2; Belongs to the potassium channel family. (598 aa)

Predicted Functional Partners:

fau

0.907

rpl23a

0.705

Rpl35

0.704

rpl29

0.703

Rpl31

0.703

rpl35a

0.701

rpl30

0.697

Rpl24

0.697

rpl32

0.696

ppfia2

0.683

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Rpl24	Rpl31	ENSPREP00000014784	ENSPREP00000015832	Ribosomal protein L24.	Ribosomal protein L31.	0.999
Rpl24	Rpl35	ENSPREP00000014784	ENSPREP00000020002	Ribosomal protein L24.	Ribosomal protein L35.	0.999
Rpl24	fau	ENSPREP00000014784	ENSPREP00000022382	Ribosomal protein L24.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
Rpl24	kcnc2	ENSPREP00000014784	ENSPREP00000020129	Ribosomal protein L24.	Potassium voltage-gated channel, Shaw-related subfamily, member 2; Belongs to the potassium channel family.	0.697
Rpl24	rpl23a	ENSPREP00000014784	ENSPREP00000025041	Ribosomal protein L24.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.999
Rpl24	rpl29	ENSPREP00000014784	ENSPREP00000010443	Ribosomal protein L24.	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family.	0.999
Rpl24	rpl30	ENSPREP00000014784	ENSPREP00000012696	Ribosomal protein L24.	Ribosomal protein L30.	0.999
Rpl24	rpl32	ENSPREP00000014784	ENSPREP00000025423	Ribosomal protein L24.	Ribosomal protein L32.	0.999
Rpl24	rpl35a	ENSPREP00000014784	ENSPREP00000000811	Ribosomal protein L24.	Ribosomal protein L35a.	0.999
Rpl31	Rpl24	ENSPREP00000015832	ENSPREP00000014784	Ribosomal protein L31.	Ribosomal protein L24.	0.999
Rpl31	Rpl35	ENSPREP00000015832	ENSPREP00000020002	Ribosomal protein L31.	Ribosomal protein L35.	0.999
Rpl31	fau	ENSPREP00000015832	ENSPREP00000022382	Ribosomal protein L31.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
Rpl31	kcnc2	ENSPREP00000015832	ENSPREP00000020129	Ribosomal protein L31.	Potassium voltage-gated channel, Shaw-related subfamily, member 2; Belongs to the potassium channel family.	0.703
Rpl31	rpl23a	ENSPREP00000015832	ENSPREP00000025041	Ribosomal protein L31.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.999
Rpl31	rpl29	ENSPREP00000015832	ENSPREP00000010443	Ribosomal protein L31.	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family.	0.999
Rpl31	rpl30	ENSPREP00000015832	ENSPREP00000012696	Ribosomal protein L31.	Ribosomal protein L30.	0.999
Rpl31	rpl32	ENSPREP00000015832	ENSPREP00000025423	Ribosomal protein L31.	Ribosomal protein L32.	0.999
Rpl31	rpl35a	ENSPREP00000015832	ENSPREP00000000811	Ribosomal protein L31.	Ribosomal protein L35a.	0.999
Rpl35	Rpl24	ENSPREP00000020002	ENSPREP00000014784	Ribosomal protein L35.	Ribosomal protein L24.	0.999
Rpl35	Rpl31	ENSPREP00000020002	ENSPREP00000015832	Ribosomal protein L35.	Ribosomal protein L31.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

8 of 941

1.07

1.08

7.32e-05

GO:0006470

Protein dephosphorylation

3 of 67

1.8

1.07

0.0074

GO:0036211

Protein modification process

7 of 1176

0.92

0.7

0.0034

GO:0006468

Protein phosphorylation

4 of 415

1.13

0.57

0.0437

GO:1901564

Organonitrogen compound metabolic process

8 of 2532

0.64

0.41

0.0241

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017018

Myosin phosphatase activity

3 of 45

1.97

1.16

0.0058

GO:0140096

Catalytic activity, acting on a protein

7 of 1272

0.89

0.64

0.0058

GO:0004672

Protein kinase activity

4 of 415

1.13

0.59

0.0390

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. GDP metabolic process, and Signaling receptor complex adaptor activity

3 of 5

2.92

2.59

1.88e-05

CL:1988

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

4 of 32

2.24

2.42

1.88e-05

CL:1900

Mixed, incl. Serine/threonine-protein kinase, and MAPK cascade

5 of 137

1.71

2.01

2.10e-05

CL:1990

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

3 of 26

2.21

1.84

0.00029

CL:13390

Cyclic nucleotide-dependent protein kinase activity, and PPM-type phosphatase, divalent cation binding

2 of 6

2.67

1.43

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

8 of 394

1.45

2.15

1.07e-07

IPR011009

Protein kinase-like domain superfamily

8 of 431

1.41

2.07

1.08e-07

IPR036457

PPM-type phosphatase-like domain superfamily

3 of 30

2.14

1.45

0.0017

IPR001932

PPM-type phosphatase-like domain

3 of 30

2.14

1.45

0.0017

IPR000222

PPM-type phosphatase, divalent cation binding

2 of 12

2.37

0.84

0.0285

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00331

Sigma factor PP2C-like phosphatases

2 of 22

2.1

0.73

0.0449

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