ENSPREP00000020240 protein (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSPREP00000020240

Uncharacterized protein. (358 aa)

Predicted Functional Partners:

LOC103472829

0.931

ENSPREP00000026548

0.907

LOC103473495

0.865

vcan

0.480

LOC103469607

0.440

LOC103473322

0.440

LOC103470440

0.435

ncam2

0.408

ncam1

0.408

LOC103478313

0.408

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000020240	ENSPREP00000026548	ENSPREP00000020240	ENSPREP00000026548	Uncharacterized protein.	C-type lectin domain-containing protein.	0.907
ENSPREP00000020240	LOC103469607	ENSPREP00000020240	ENSPREP00000021488	Uncharacterized protein.	Tenascin C.	0.440
ENSPREP00000020240	LOC103470440	ENSPREP00000020240	ENSPREP00000006103	Uncharacterized protein.	Hyaluronan and proteoglycan link protein 1a.	0.435
ENSPREP00000020240	LOC103472829	ENSPREP00000020240	ENSPREP00000032287	Uncharacterized protein.	Uncharacterized protein.	0.931
ENSPREP00000020240	LOC103473322	ENSPREP00000020240	ENSPREP00000028988	Uncharacterized protein.	Zmp:0000000846.	0.440
ENSPREP00000020240	LOC103473495	ENSPREP00000020240	ENSPREP00000020282	Uncharacterized protein.	Uncharacterized protein.	0.865
ENSPREP00000020240	LOC103478313	ENSPREP00000020240	ENSPREP00000020122	Uncharacterized protein.	Neural cell adhesion molecule 3.	0.408
ENSPREP00000020240	ncam1	ENSPREP00000020240	ENSPREP00000016214	Uncharacterized protein.	Neural cell adhesion molecule 1b.	0.408
ENSPREP00000020240	ncam2	ENSPREP00000020240	ENSPREP00000009341	Uncharacterized protein.	Zgc:152904.	0.408
ENSPREP00000020240	vcan	ENSPREP00000020240	ENSPREP00000006088	Uncharacterized protein.	Versican a.	0.480
ENSPREP00000026548	ENSPREP00000020240	ENSPREP00000026548	ENSPREP00000020240	C-type lectin domain-containing protein.	Uncharacterized protein.	0.907
LOC103469607	ENSPREP00000020240	ENSPREP00000021488	ENSPREP00000020240	Tenascin C.	Uncharacterized protein.	0.440
LOC103469607	LOC103472829	ENSPREP00000021488	ENSPREP00000032287	Tenascin C.	Uncharacterized protein.	0.530
LOC103469607	LOC103473322	ENSPREP00000021488	ENSPREP00000028988	Tenascin C.	Zmp:0000000846.	0.445
LOC103469607	LOC103473495	ENSPREP00000021488	ENSPREP00000020282	Tenascin C.	Uncharacterized protein.	0.440
LOC103469607	vcan	ENSPREP00000021488	ENSPREP00000006088	Tenascin C.	Versican a.	0.440
LOC103470440	ENSPREP00000020240	ENSPREP00000006103	ENSPREP00000020240	Hyaluronan and proteoglycan link protein 1a.	Uncharacterized protein.	0.435
LOC103470440	LOC103472829	ENSPREP00000006103	ENSPREP00000032287	Hyaluronan and proteoglycan link protein 1a.	Uncharacterized protein.	0.890
LOC103470440	LOC103473495	ENSPREP00000006103	ENSPREP00000020282	Hyaluronan and proteoglycan link protein 1a.	Uncharacterized protein.	0.621
LOC103470440	vcan	ENSPREP00000006103	ENSPREP00000006088	Hyaluronan and proteoglycan link protein 1a.	Versican a.	0.919

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

2.15e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000077

DNA damage checkpoint signaling

7 of 79

2.27

5.21

6.50e-12

GO:0044773

Mitotic DNA damage checkpoint signaling

6 of 63

2.3

4.64

2.28e-10

GO:0071479

Cellular response to ionizing radiation

5 of 38

2.44

4.27

3.82e-09

GO:0007095

Mitotic G2 DNA damage checkpoint signaling

5 of 41

2.4

4.2

4.66e-09

GO:0006281

DNA repair

10 of 415

1.7

3.87

1.94e-13

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030870

Mre11 complex

3 of 3

3.32

3.31

1.04e-06

GO:0000781

Chromosome, telomeric region

4 of 56

2.17

2.62

5.85e-06

GO:0031436

BRCA1-BARD1 complex

2 of 3

3.14

2.02

0.00022

GO:0000794

Condensed nuclear chromosome

3 of 49

2.1

1.87

0.00021

GO:0035861

Site of double-strand break

3 of 52

2.08

1.86

0.00022

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32796846

(2020) A scalable CRISPRCas9-based fluorescent reporter assay to study DNA double-strand break repair choice.

3 of 25

2.4

1.95

0.00022

PMID:38102134

(2023) Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.

3 of 42

2.17

1.73

0.00048

PMID:33742045

(2021) Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma.

2 of 11

2.58

1.28

0.0045

PMID:37627523

(2023) Natural Acetogenins, Chatenaytrienins-1, -2, -3 and -4, Mitochondrial Potential Uncouplers and Autophagy Inducers-Promising Anticancer Agents.

2 of 36

2.06

0.81

0.0301

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7103

Mixed, incl. Mre11 complex, and BRCA1-BARD1 complex

9 of 11

3.23

12.3

9.80e-24

CL:7105

Mre11 complex, and Flap-structured DNA binding

4 of 5

3.22

4.77

2.02e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03440

Homologous recombination

5 of 27

2.59

5.06

1.47e-10

pret04218

Cellular senescence

8 of 178

1.97

4.81

4.42e-13

pret04115

p53 signaling pathway

5 of 78

2.12

3.67

1.40e-08

pret04110

Cell cycle

5 of 120

1.94

3.11

8.41e-08

pret03450

Non-homologous end-joining

2 of 11

2.58

1.77

0.00054

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69473

G2/M DNA damage checkpoint

10 of 101

2.31

8.16

8.73e-20

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

10 of 125

2.22

7.56

3.33e-19

MAP-5685938

HDR through Single Strand Annealing (SSA)

7 of 45

2.51

6.75

1.61e-14

MAP-5693616

Presynaptic phase of homologous DNA pairing and strand exchange

6 of 24

2.72

6.57

1.91e-13

MAP-5693579

Homologous DNA Pairing and Strand Exchange

6 of 26

2.68

6.48

2.49e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030870

Mre11 complex

4 of 5

3.22

4.53

5.58e-09

GOCC:0031436

BRCA1-BARD1 complex

2 of 5

2.92

1.46

0.0023

GOCC:0070531

BRCA1-A complex

2 of 15

2.44

1.12

0.0087

GOCC:0005634

Nucleus

10 of 3523

0.77

0.71

5.55e-05

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.31

0.0100

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0227

DNA damage

2 of 27

2.19

0.84

0.0283

KW-0723

Serine/threonine-protein kinase

3 of 233

1.43

0.73

0.0283

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02259

FAT domain

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036420

BRCT domain superfamily

4 of 27

2.49

2.75

6.43e-06

IPR001357

BRCT domain

3 of 23

2.43

1.68

0.00076

IPR003151

PIK-related kinase, FAT

2 of 4

3.02

1.18

0.0075

IPR014009

PIK-related kinase

2 of 5

2.92

1.17

0.0078

IPR003152

FATC domain

2 of 6

2.84

1.15

0.0083

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00292

Breast cancer carboxy-terminal domain

4 of 22

2.58

3.42

3.35e-07

SM01343

The FATC domain is named after FRAP, ATM, TRRAP C-terminal (PMID:10782091). The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability (PMID:15772072).

2 of 6

2.84

1.45

0.0023

SM00240

Forkhead associated domain

2 of 27

2.19

0.89

0.0220

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